IL1F10 interleukin 1 family member 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL1F10provided by HGNC
Official Full Name: interleukin 1 family member 10provided by HGNC
Primary source: HGNC:HGNC:15552
See related: Ensembl:ENSG00000136697 MIM:615296
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IL-38; FKSG75; IL1HY2; IL-1HY2; IL1-theta; FIL1-theta
Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward skin (RPKM 1.0) See more
Orthologs: mouse all
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Genomic context

Location:: 2q14.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	2	NC_000002.12 (113067970..113075843)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (113825547..113833420)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects.
Title: Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects.
Interleukin-38 is elevated in inflammatory bowel diseases and suppresses intestinal inflammation.
Title: Interleukin-38 is elevated in inflammatory bowel diseases and suppresses intestinal inflammation.
Biology of interleukin-38 and its role in chronic inflammatory diseases.
Title: Biology of interleukin-38 and its role in chronic inflammatory diseases.
IL-38: A novel cytokine in systemic lupus erythematosus pathogenesis.
Title: IL-38: A novel cytokine in systemic lupus erythematosus pathogenesis.
The elevated expression of IL-38 serves as an anti-inflammatory factor in osteoarthritis and its protective effect in osteoarthritic chondrocytes.
Title: The elevated expression of IL-38 serves as an anti-inflammatory factor in osteoarthritis and its protective effect in osteoarthritic chondrocytes.
Elevated IL-38 inhibits IL-23R expression and IL-17A production in thyroid-associated ophthalmopathy.
Title: Elevated IL-38 inhibits IL-23R expression and IL-17A production in thyroid-associated ophthalmopathy.
New aspect of allergic contact dermatitis, an inflammatory skin disorder mediated by mast cells: Can IL-38 help?
Title: New aspect of allergic contact dermatitis, an inflammatory skin disorder mediated by mast cells: Can IL-38 help?
IL-38 alleviates the inflammatory response and the degeneration of nucleus pulposus cells via inhibition of the NF-kappaB signaling pathway in vitro.
Title: IL-38 alleviates the inflammatory response and the degeneration of nucleus pulposus cells via inhibition of the NF-κB signaling pathway in vitro.
Interleukin-38 promotes tumor growth through regulation of CD8(+) tumor-infiltrating lymphocytes in lung cancer tumor microenvironment.
Title: Interleukin-38 promotes tumor growth through regulation of CD8<sup>+</sup> tumor-infiltrating lymphocytes in lung cancer tumor microenvironment.
Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections.
Title: Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
A genome-wide association study identifies protein quantitative trait loci (pQTLs). GeneReviews: Not available
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. GeneReviews: Not available
Meta-analysis of genome-wide association studies in &gt;80 000 subjects identifies multiple loci for C-reactive protein levels. GeneReviews: Not available
Multiethnic meta-analysis of genome-wide association studies in &gt;100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. GeneReviews: Not available
Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults. GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484155

SHGC-106894 (e-PCR)
- UniSTS:183260

NoName (e-PCR)
- UniSTS:481253

Homology

Homologs of the IL1F10 gene: The IL1F10 gene is conserved in chimpanzee, dog, cow, mouse, and rat.
Orthologs from Annotation Pipeline: 159 organisms have orthologs with human gene IL1F10
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables interleukin-1 receptor binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in inflammatory response to antigenic stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: interleukin-1 family member 10

Names: FIL1 theta; IL-1 theta; IL-1F10 (canonical form IL-1F10a); family of interleukin 1-theta; interleukin 1 family member 10 (theta); interleukin-1 HY2; interleukin-1 receptor antagonist FKSG75; interleukin-1 receptor antagonist-like FIL1 theta; interleukin-38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032556.6 → NP_115945.4 interleukin-1 family member 10

See identical proteins and their annotated locations for NP_115945.4

Status: REVIEWED

Source sequence(s)

AC016724, AF334755, AY358846

Consensus CDS

CCDS2112.1

UniProtKB/Swiss-Prot

Q8WWZ1

Related

ENSP00000376893.2, ENST00000393197.3

Conserved Domains (1) summary

cl00094
Location:10 → 149

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
NM_173161.3 → NP_775184.1 interleukin-1 family member 10

See identical proteins and their annotated locations for NP_775184.1

Status: REVIEWED

Source sequence(s)

AY029413, AY358846

Consensus CDS

CCDS2112.1

UniProtKB/Swiss-Prot

Q8WWZ1

Related

ENSP00000341794.2, ENST00000341010.6

Conserved Domains (1) summary

cl00094
Location:10 → 149

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).