Format

Send to:

Choose Destination

IL1F10 interleukin 1 family member 10 [ Homo sapiens (human) ]

Gene ID: 84639, updated on 22-Aug-2021

Summary

Official Symbol
IL1F10provided by HGNC
Official Full Name
interleukin 1 family member 10provided by HGNC
Primary source
HGNC:HGNC:15552
See related
Ensembl:ENSG00000136697 MIM:615296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-38; FKSG75; IL1HY2; IL-1HY2; IL1-theta; FIL1-theta
Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward skin (RPKM 1.0) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See IL1F10 in Genome Data Viewer
Location:
2q14.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (113067970..113075843)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113825547..113833420)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 36 beta Neighboring gene interleukin 36 receptor antagonist Neighboring gene Sharpr-MPRA regulatory region 10370 Neighboring gene RNA, U6 small nuclear 1180, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
GeneReviews: Not available
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
GeneReviews: Not available
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
GeneReviews: Not available
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
GeneReviews: Not available
Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119831, MGC119832, MGC119833

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-1 receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response to antigenic stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-1 family member 10
Names
FIL1 theta
IL-1 theta
IL-1F10 (canonical form IL-1F10a)
family of interleukin 1-theta
interleukin 1 family member 10 (theta)
interleukin-1 HY2
interleukin-1 receptor antagonist FKSG75
interleukin-1 receptor antagonist-like FIL1 theta
interleukin-38

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032556.6NP_115945.4  interleukin-1 family member 10

    See identical proteins and their annotated locations for NP_115945.4

    Status: REVIEWED

    Source sequence(s)
    AC016724, AF334755, AY358846
    Consensus CDS
    CCDS2112.1
    UniProtKB/Swiss-Prot
    Q8WWZ1
    Related
    ENSP00000376893.2, ENST00000393197.3
    Conserved Domains (1) summary
    cl00094
    Location:10149
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  2. NM_173161.3NP_775184.1  interleukin-1 family member 10

    See identical proteins and their annotated locations for NP_775184.1

    Status: REVIEWED

    Source sequence(s)
    AY029413, AY358846
    Consensus CDS
    CCDS2112.1
    UniProtKB/Swiss-Prot
    Q8WWZ1
    Related
    ENSP00000341794.2, ENST00000341010.6
    Conserved Domains (1) summary
    cl00094
    Location:10149
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    113067970..113075843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center