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NT5C1A 5'-nucleotidase, cytosolic IA [ Homo sapiens (human) ]

Gene ID: 84618, updated on 8-Jul-2021

Summary

Official Symbol
NT5C1Aprovided by HGNC
Official Full Name
5'-nucleotidase, cytosolic IAprovided by HGNC
Primary source
HGNC:HGNC:17819
See related
Ensembl:ENSG00000116981 MIM:610525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CN1; CNI; CN-I; CN1A; CN-IA
Summary
Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in heart (RPKM 3.5), brain (RPKM 1.5) and 5 other tissues See more
Orthologs
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Genomic context

See NT5C1A in Genome Data Viewer
Location:
1p34.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (39651229..39672107, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40116901..40137779, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PABPC4 antisense RNA 1 Neighboring gene poly(A) binding protein cytoplasmic 4 Neighboring gene small nucleolar RNA, H/ACA box 55 Neighboring gene hes related family bHLH transcription factor with YRPW motif like Neighboring gene Sharpr-MPRA regulatory region 4263 Neighboring gene hippocalcin like 4 Neighboring gene coiled-coil domain containing 25 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119199, MGC119201

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5'-nucleotidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables IMP 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in AMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in IMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in allantoin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dAMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dGMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleoside metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cytosolic 5'-nucleotidase 1A
Names
AMP-specific 5'-NT
cytosolic 5' nucleotidase, type 1A
cytosolic 5'-nucleotidase IA
NP_115915.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032526.3NP_115915.1  cytosolic 5'-nucleotidase 1A

    See identical proteins and their annotated locations for NP_115915.1

    Status: VALIDATED

    Source sequence(s)
    AL035404
    Consensus CDS
    CCDS440.1
    UniProtKB/Swiss-Prot
    Q9BXI3
    Related
    ENSP00000235628.1, ENST00000235628.2
    Conserved Domains (1) summary
    pfam06189
    Location:81349
    5-nucleotidase; 5'-nucleotidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    39651229..39672107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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