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NT5C1A 5'-nucleotidase, cytosolic IA [ Homo sapiens (human) ]

Gene ID: 84618, updated on 18-Sep-2024

Summary

Official Symbol
NT5C1Aprovided by HGNC
Official Full Name
5'-nucleotidase, cytosolic IAprovided by HGNC
Primary source
HGNC:HGNC:17819
See related
Ensembl:ENSG00000116981 MIM:610525; AllianceGenome:HGNC:17819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CN1; CNI; CN-I; CN1A; CN-IA
Summary
Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in heart (RPKM 3.5), brain (RPKM 1.5) and 5 other tissues See more
Orthologs
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Genomic context

See NT5C1A in Genome Data Viewer
Location:
1p34.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (39651229..39672107, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (39519647..39541479, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40116901..40137779, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PABPC4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40036267-40036768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40036769-40037268 Neighboring gene poly(A) binding protein cytoplasmic 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 813 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 703 Neighboring gene small nucleolar RNA, H/ACA box 55 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 705 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7951 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7954 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 707 Neighboring gene hes related family bHLH transcription factor with YRPW motif like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 708 Neighboring gene Sharpr-MPRA regulatory region 4263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 709 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:40155381-40155607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 711 Neighboring gene hippocalcin like 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40157484-40158074 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40166488-40167140 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:40176174-40176931 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:40177551-40178246 Neighboring gene coiled-coil domain containing 25 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC119199, MGC119201

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5'-deoxynucleotidase activity IEA
Inferred from Electronic Annotation
more info
 
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5'-nucleotidase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables IMP 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables XMP 5'-nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in AMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in IMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in allantoin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dAMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dGMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleoside metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cytosolic 5'-nucleotidase 1A
Names
5'-deoxynucleotidase
AMP-specific 5'-NT
cytosolic 5' nucleotidase, type 1A
cytosolic 5'-nucleotidase IA
NP_115915.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032526.3NP_115915.1  cytosolic 5'-nucleotidase 1A

    See identical proteins and their annotated locations for NP_115915.1

    Status: VALIDATED

    Source sequence(s)
    AL035404
    Consensus CDS
    CCDS440.1
    UniProtKB/Swiss-Prot
    Q3SYB9, Q5TG98, Q9BWT8, Q9BXI3
    Related
    ENSP00000235628.1, ENST00000235628.2
    Conserved Domains (1) summary
    pfam06189
    Location:81349
    5-nucleotidase; 5'-nucleotidase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    39651229..39672107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    39519647..39541479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)