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RHOXF2 Rhox homeobox family member 2 [ Homo sapiens (human) ]

Gene ID: 84528, updated on 11-Sep-2019

Summary

Official Symbol
RHOXF2provided by HGNC
Official Full Name
Rhox homeobox family member 2provided by HGNC
Primary source
HGNC:HGNC:30011
See related
Ensembl:ENSG00000131721 MIM:300447
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THG1; CT107; PEPP2; PEPP-2
Summary
This gene, which encodes a transcriptional repressor, is one of two paralogous X-linked homeobox-containing genes and is highly expressed in a variety of cancers. In addition, the encoded protein associates with the cell membrane and with microtubules, and is concentrated at the leading edge of migratory cells. [provided by RefSeq, Dec 2015]
Expression
Restricted expression toward testis (RPKM 22.1) See more
Orthologs

Genomic context

See RHOXF2 in Genome Data Viewer
Location:
Xq24
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (120158535..120165630)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (119292432..119297933)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RHOXF1 antisense RNA 1 Neighboring gene Rhox homeobox family member 2B Neighboring gene Rhox homeobox family member 1 Neighboring gene long intergenic non-protein coding RNA 1402 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 30 Neighboring gene SFR1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rhox homeobox family member 2
Names
PEPP subfamily gene 2
cancer/testis antigen 107
homeobox protein from AL590526
paired-like homeobox protein PEPP-2
testis homeobox gene 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032498.3NP_115887.1  rhox homeobox family member 2

    See identical proteins and their annotated locations for NP_115887.1

    Status: REVIEWED

    Source sequence(s)
    AC240549, AL590526, BC021719
    Consensus CDS
    CCDS14594.1
    UniProtKB/Swiss-Prot
    Q9BQY4
    Related
    ENSP00000360441.3, ENST00000371388.4
    Conserved Domains (1) summary
    pfam00046
    Location:140190
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    120158535..120165630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262484.4XP_005262541.1  rhox homeobox family member 2 isoform X1

    Conserved Domains (1) summary
    cl00084
    Location:140159
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
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