Format

Send to:

Choose Destination

DOC2B double C2 domain beta [ Homo sapiens (human) ]

Gene ID: 8447, updated on 13-Mar-2020

Summary

Official Symbol
DOC2Bprovided by HGNC
Official Full Name
double C2 domain betaprovided by HGNC
Primary source
HGNC:HGNC:2986
See related
Ensembl:ENSG00000272636 MIM:604568
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOC2BL
Summary
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 3.2), bone marrow (RPKM 2.6) and 22 other tissues See more
Orthologs

Genomic context

See DOC2B in Genome Data Viewer
Location:
17p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (142789..181650, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6009..31421, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929823 Neighboring gene uncharacterized LOC101929828 Neighboring gene secretoglobin family 1C member 2 Neighboring gene long intergenic non-protein coding RNA 2091 Neighboring gene rabphilin 3A like (without C2 domains) Neighboring gene uncharacterized LOC100506388

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
calcium ion-regulated exocytosis of neurotransmitter ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of calcium ion-dependent exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vesicle fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
spontaneous neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with SNARE complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
double C2-like domain-containing protein beta
Names
doc2-beta
double C2-like domains, beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021143.2 RefSeqGene

    Range
    5001..39824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003585.5NP_003576.2  double C2-like domain-containing protein beta

    See identical proteins and their annotated locations for NP_003576.2

    Status: REVIEWED

    Source sequence(s)
    AC108004, AC240565, AI478508, D70830
    Consensus CDS
    CCDS73934.1
    UniProtKB/Swiss-Prot
    Q14184
    UniProtKB/TrEMBL
    A0A087WZX8
    Related
    ENSP00000482950.1, ENST00000613549.3
    Conserved Domains (2) summary
    cd04035
    Location:127250
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:269401
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    142789..181650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535363.3XP_011533665.1  double C2-like domain-containing protein beta isoform X1

    Conserved Domains (2) summary
    cd08384
    Location:244376
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
    cl14603
    Location:127225
    C2; C2 domain
  2. XM_017025227.1XP_016880716.1  double C2-like domain-containing protein beta isoform X2

RNA

  1. XR_001752664.1 RNA Sequence

  2. XR_942189.2 RNA Sequence

  3. XR_942190.2 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315952.3 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    82789..120582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center