U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MEGF11 multiple EGF like domains 11 [ Homo sapiens (human) ]

Gene ID: 84465, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
MEGF11provided by HGNC
Official Full Name
multiple EGF like domains 11provided by HGNC
Primary source
HGNC:HGNC:29635
See related
Ensembl:ENSG00000157890 MIM:612454; AllianceGenome:HGNC:29635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable scavenger receptor activity. Predicted to be involved in homotypic cell-cell adhesion and retina layer formation. Predicted to be located in basolateral plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 3.0), testis (RPKM 0.5) and 2 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MEGF11 in Genome Data Viewer
Location:
15q22.31
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65895299..66253750, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (63704723..64075393, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (66187637..66546088, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9609 Neighboring gene tRNA-Gln (anticodon CTG) 1-4 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66194834-66194998 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:66195001-66195792 Neighboring gene RAB11A, member RAS oncogene family Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66214128-66214697 Neighboring gene Sharpr-MPRA regulatory region 15210 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:66246132-66246645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66249933-66250434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66249429-66249932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66256890-66257866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66272648-66273148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66273149-66273649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66274440-66274940 Neighboring gene uncharacterized LOC105370867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66315774-66316274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66316275-66316775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66340493-66341368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66349054-66349554 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66357857-66358057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66358200-66358762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66365553-66366053 Neighboring gene microRNA 4311 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:66371850-66372818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:66372819-66373785 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66388655-66389435 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66408056-66408295 Neighboring gene Sharpr-MPRA regulatory region 9514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66435333-66436223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66460026-66460820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66461585-66462085 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:66472833-66473489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66591355-66591855 Neighboring gene DIS3L antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66630872-66631107 Neighboring gene DIS3 like exosome 3'-5' exoribonuclease Neighboring gene small Cajal body-specific RNA 14 Neighboring gene TIMELESS interacting protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Overexpression of multiple epidermal growth factor like domains 11 rescues anoikis survival through tumor cells-platelet interaction in triple negative breast Cancer cells. Huang CP, et al. Life Sci, 2022 Jun 15. PMID 35398017
  2. The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern. Suzuki E, et al. Exp Cell Res, 2007 Jul 1. PMID 17498693
  3. Prenatal phthalate exposure and cord blood DNA methylation. Lee J, et al. Sci Rep, 2023 Apr 29. PMID 37120575, Free PMC Article
  4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. Oguri M, et al. Am J Hypertens, 2010 Jan. PMID 19851296

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prenatal phthalate exposure and cord blood DNA methylation.
    Title: Prenatal phthalate exposure and cord blood DNA methylation.
  2. Overexpression of multiple epidermal growth factor like domains 11 rescues anoikis survival through tumor cells-platelet interaction in triple negative breast Cancer cells.
    Title: Overexpression of multiple epidermal growth factor like domains 11 rescues anoikis survival through tumor cells-platelet interaction in triple negative breast Cancer cells.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA1781, DKFZp434L121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in homotypic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retina layer formation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
multiple epidermal growth factor-like domains protein 11
Names
multiple EGF-like domains protein 11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385028.1 → NP_001371957.1  multiple epidermal growth factor-like domains protein 11 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC011847, AC084854, AC087382
    Consensus CDS
    CCDS92027.1
    UniProtKB/TrEMBL
    A0A0A0MS64
    Related
    ENSP00000378976.2, ENST00000395614.6
    Conserved Domains (2) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain
    cl21504
    Location:275 → 320
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  2. NM_001385029.1 → NP_001371958.1  multiple epidermal growth factor-like domains protein 11 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382
    UniProtKB/TrEMBL
    A0A0G2JN40
    Conserved Domains (2) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain
    cl21504
    Location:275 → 320
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  3. NM_001385030.1 → NP_001371959.1  multiple epidermal growth factor-like domains protein 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382
    Consensus CDS
    CCDS92026.1
    UniProtKB/TrEMBL
    A0A0G2JLW8
    Related
    ENSP00000288745.3, ENST00000288745.7

  4. NM_001385031.1 → NP_001371960.1  multiple epidermal growth factor-like domains protein 11 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382
    UniProtKB/TrEMBL
    A0A0G2JLW8

  5. NM_001385032.1 → NP_001371961.1  multiple epidermal growth factor-like domains protein 11 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382
    UniProtKB/TrEMBL
    A0A0G2JLW8

  6. NM_001385033.1 → NP_001371962.1  multiple epidermal growth factor-like domains protein 11 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382
    UniProtKB/TrEMBL
    A0A0G2JN40
    Conserved Domains (1) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain

  7. NM_001387150.1 → NP_001374079.1  multiple epidermal growth factor-like domains protein 11 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC011847, AC084854, AC087382
    Consensus CDS
    CCDS10213.2
    UniProtKB/Swiss-Prot
    A6BM72, Q17R86, Q6UXS5, Q8ND91, Q96KG6
    UniProtKB/TrEMBL
    A0A0G2JN40
    Related
    ENSP00000386908.2, ENST00000409699.6
    Conserved Domains (2) summary
    pfam07546
    Location:25 → 94
    EMI; EMI domain
    cl21504
    Location:275 → 320
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  8. NM_001387151.1 → NP_001374080.1  multiple epidermal growth factor-like domains protein 11 isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC087382
    Conserved Domains (1) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain

  9. NM_032445.3 → NP_115821.2  multiple epidermal growth factor-like domains protein 11 isoform 2 precursor

    See identical proteins and their annotated locations for NP_115821.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 13, encodes isoform 2.
    Source sequence(s)
    AC011847, AC084854, AC087382
    Consensus CDS
    CCDS10213.2
    UniProtKB/Swiss-Prot
    A6BM72, Q17R86, Q6UXS5, Q8ND91, Q96KG6
    UniProtKB/TrEMBL
    A0A0G2JN40
    Related
    ENSP00000414475.1, ENST00000422354.6
    Conserved Domains (2) summary
    pfam07546
    Location:25 → 94
    EMI; EMI domain
    cl21504
    Location:275 → 320
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RNA

  1. NR_169554.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382

  2. NR_169555.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382

  3. NR_169556.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382

  4. NR_169557.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382

  5. NR_169558.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    65895299..66253750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022670.3 → XP_016878159.1  multiple epidermal growth factor-like domains protein 11 isoform X1

  2. XM_047433168.1 → XP_047289124.1  multiple epidermal growth factor-like domains protein 11 isoform X6

  3. XM_047433165.1 → XP_047289121.1  multiple epidermal growth factor-like domains protein 11 isoform X4

    UniProtKB/TrEMBL
    A0A0A0MS64

  4. XM_017022671.3 → XP_016878160.1  multiple epidermal growth factor-like domains protein 11 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JN40

  5. XM_017022674.3 → XP_016878163.1  multiple epidermal growth factor-like domains protein 11 isoform X8

  6. XM_017022675.3 → XP_016878164.1  multiple epidermal growth factor-like domains protein 11 isoform X8

  7. XM_047433169.1 → XP_047289125.1  multiple epidermal growth factor-like domains protein 11 isoform X7

  8. XM_047433167.1 → XP_047289123.1  multiple epidermal growth factor-like domains protein 11 isoform X5

  9. XM_017022673.3 → XP_016878162.1  multiple epidermal growth factor-like domains protein 11 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JN40
    Conserved Domains (2) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain
    cl21504
    Location:275 → 320
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  10. XM_047433166.1 → XP_047289122.1  multiple epidermal growth factor-like domains protein 11 isoform X3

  11. XM_047433170.1 → XP_047289126.1  multiple epidermal growth factor-like domains protein 11 isoform X9

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315944.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    850..357705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    63704723..64075393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378985.1 → XP_054234960.1  multiple epidermal growth factor-like domains protein 11 isoform X1

  2. XM_054378984.1 → XP_054234959.1  multiple epidermal growth factor-like domains protein 11 isoform X4

  3. XM_054378986.1 → XP_054234961.1  multiple epidermal growth factor-like domains protein 11 isoform X2

  4. XM_054378992.1 → XP_054234967.1  multiple epidermal growth factor-like domains protein 11 isoform X8

  5. XM_054378993.1 → XP_054234968.1  multiple epidermal growth factor-like domains protein 11 isoform X8

  6. XM_054378990.1 → XP_054234965.1  multiple epidermal growth factor-like domains protein 11 isoform X6

  7. XM_054378991.1 → XP_054234966.1  multiple epidermal growth factor-like domains protein 11 isoform X7

  8. XM_054378989.1 → XP_054234964.1  multiple epidermal growth factor-like domains protein 11 isoform X5

  9. XM_054378988.1 → XP_054234963.1  multiple epidermal growth factor-like domains protein 11 isoform X4

  10. XM_054378987.1 → XP_054234962.1  multiple epidermal growth factor-like domains protein 11 isoform X3

  11. XM_054378994.1 → XP_054234969.1  multiple epidermal growth factor-like domains protein 11 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6BM72.3 GenPept UniProtKB/Swiss-Prot:A6BM72

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools