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MEGF11 multiple EGF like domains 11 [ Homo sapiens (human) ]

Gene ID: 84465, updated on 5-Sep-2021

Summary

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Official Symbol
MEGF11provided by HGNC
Official Full Name
multiple EGF like domains 11provided by HGNC
Primary source
HGNC:HGNC:29635
See related
Ensembl:ENSG00000157890 MIM:612454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 3.0), testis (RPKM 0.5) and 2 other tissues See more
Orthologs
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Genomic context

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See MEGF11 in Genome Data Viewer
Location:
15q22.31
Exon count:
29
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (65889717..66253750, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (66187637..66546088, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370866 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 44 Neighboring gene tRNA-Gln (anticodon CTG) 1-4 Neighboring gene RAB11A, member RAS oncogene family Neighboring gene Sharpr-MPRA regulatory region 15210 Neighboring gene uncharacterized LOC105370867 Neighboring gene microRNA 4311 Neighboring gene DIS3L antisense RNA 1 Neighboring gene DIS3 like exosome 3'-5' exoribonuclease Neighboring gene small Cajal body-specific RNA 14 Neighboring gene TIMELESS interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern. Suzuki E, et al. Exp Cell Res, 2007 Jul 1. PMID 17498693
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. Oguri M, et al. Am J Hypertens, 2010 Jan. PMID 19851296
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. Yoshida T, et al. Int J Mol Med, 2010 Apr. PMID 20198315
  5. Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein. Meng X, et al. J Biol Chem, 2012 Feb 10. PMID 22199357, Free PMC Article

See all (12) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1781, DKFZp434L121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in homotypic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retina layer formation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
multiple epidermal growth factor-like domains protein 11
Names
multiple EGF-like domains protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385028.1 → NP_001371957.1  multiple epidermal growth factor-like domains protein 11 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC011847, AC084854, AC087382
    Related
    ENSP00000378976.2, ENST00000395614.6
    Conserved Domains (2) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain
    cl21504
    Location:275 → 320
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  2. NM_001385029.1 → NP_001371958.1  multiple epidermal growth factor-like domains protein 11 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382
    Conserved Domains (2) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain
    cl21504
    Location:275 → 320
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  3. NM_001385030.1 → NP_001371959.1  multiple epidermal growth factor-like domains protein 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382
    Related
    ENSP00000288745.3, ENST00000288745.7

  4. NM_001385031.1 → NP_001371960.1  multiple epidermal growth factor-like domains protein 11 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382

  5. NM_001385032.1 → NP_001371961.1  multiple epidermal growth factor-like domains protein 11 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382

  6. NM_001385033.1 → NP_001371962.1  multiple epidermal growth factor-like domains protein 11 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382
    Conserved Domains (1) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain

  7. NM_001387150.1 → NP_001374079.1  multiple epidermal growth factor-like domains protein 11 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC011847, AC084854, AC087382
    Related
    ENSP00000386908.2, ENST00000409699.6
    Conserved Domains (2) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain
    cl21504
    Location:275 → 320
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  8. NM_001387151.1 → NP_001374080.1  multiple epidermal growth factor-like domains protein 11 isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC087382
    Conserved Domains (1) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain

  9. NM_032445.3 → NP_115821.2  multiple epidermal growth factor-like domains protein 11 isoform 2 precursor

    See identical proteins and their annotated locations for NP_115821.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 13, encodes isoform 2.
    Source sequence(s)
    AC011847, AC084854, AC087382
    Consensus CDS
    CCDS10213.2
    UniProtKB/Swiss-Prot
    A6BM72
    Related
    ENSP00000414475.1, ENST00000422354.5
    Conserved Domains (2) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain
    cl21504
    Location:275 → 320
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RNA

  1. NR_169554.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382

  2. NR_169555.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382

  3. NR_169556.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382

  4. NR_169557.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382

  5. NR_169558.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011847, AC084854, AC087382

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    65889717..66253750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022672.2 → XP_016878161.1  multiple epidermal growth factor-like domains protein 11 isoform X3

    UniProtKB/Swiss-Prot
    A6BM72
    Conserved Domains (2) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain
    cl21504
    Location:275 → 320
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  2. XM_017022670.2 → XP_016878159.1  multiple epidermal growth factor-like domains protein 11 isoform X1

  3. XM_017022671.2 → XP_016878160.1  multiple epidermal growth factor-like domains protein 11 isoform X2

  4. XM_017022674.2 → XP_016878163.1  multiple epidermal growth factor-like domains protein 11 isoform X5

  5. XM_017022675.2 → XP_016878164.1  multiple epidermal growth factor-like domains protein 11 isoform X5

  6. XM_017022673.2 → XP_016878162.1  multiple epidermal growth factor-like domains protein 11 isoform X4

    Conserved Domains (2) summary
    pfam07546
    Location:26 → 93
    EMI; EMI domain
    cl21504
    Location:275 → 320
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315944.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    850..357705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6BM72.3 GenPept UniProtKB/Swiss-Prot:A6BM72

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