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ECRG4 ECRG4 augurin precursor [ Homo sapiens (human) ]

Gene ID: 84417, updated on 19-Sep-2024

Summary

Official Symbol
ECRG4provided by HGNC
Official Full Name
ECRG4 augurin precursorprovided by HGNC
Primary source
HGNC:HGNC:24642
See related
Ensembl:ENSG00000119147 MIM:611752; AllianceGenome:HGNC:24642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2orf40
Summary
Enables neuropeptide hormone activity. Involved in neuropeptide signaling pathway; positive regulation of hormone secretion; and vasopressin secretion. Located in apical plasma membrane; dense core granule; and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in fat (RPKM 29.6), thyroid (RPKM 20.4) and 17 other tissues See more
Orthologs
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Genomic context

See ECRG4 in Genome Data Viewer
Location:
2q12.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (106063241..106078155)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (106524934..106539858)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (106682144..106694611)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373530 Neighboring gene uncharacterized LOC105373531 Neighboring gene NANOG hESC enhancer GRCh37_chr2:106567089-106567923 Neighboring gene uncharacterized LOC124906055 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:106669310-106670509 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:106713148-106713820 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:106713821-106714492 Neighboring gene UDP-glucuronate decarboxylase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:106746920-106747434 Neighboring gene Sharpr-MPRA regulatory region 936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16338 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:106781527-106782046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11846 Neighboring gene ribosomal protein L22 pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neuropeptide hormone activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G1 to G0 transition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular senescence IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in central nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in neuropeptide signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of corticosterone secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of corticotropin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of corticotropin-releasing hormone secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in vasopressin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in dense core granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
augurin
Names
esophageal cancer related gene 4 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032411.3NP_115787.1  augurin precursor

    See identical proteins and their annotated locations for NP_115787.1

    Status: VALIDATED

    Source sequence(s)
    AF325503, BC021742
    Consensus CDS
    CCDS2072.1
    UniProtKB/Swiss-Prot
    D3DVK2, Q9H1Z8
    Related
    ENSP00000238044.3, ENST00000238044.8
    Conserved Domains (1) summary
    pfam15187
    Location:32148
    Augurin; Oesophageal cancer-related gene 4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    106063241..106078155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446022.1XP_047301978.1  augurin isoform X1

    UniProtKB/TrEMBL
    C9JRR0
  2. XM_006712799.4XP_006712862.1  augurin isoform X2

    See identical proteins and their annotated locations for XP_006712862.1

    UniProtKB/TrEMBL
    B8ZZE5
    Related
    ENSP00000386421.1, ENST00000409944.5
    Conserved Domains (1) summary
    pfam15187
    Location:1112
    Augurin; Oesophageal cancer-related gene 4
  3. XM_047446023.1XP_047301979.1  augurin isoform X1

    UniProtKB/TrEMBL
    C9JRR0
    Related
    ENSP00000388664.1, ENST00000437659.1
  4. XM_011511993.3XP_011510295.1  augurin isoform X2

    See identical proteins and their annotated locations for XP_011510295.1

    UniProtKB/TrEMBL
    B8ZZE5
    Conserved Domains (1) summary
    pfam15187
    Location:1112
    Augurin; Oesophageal cancer-related gene 4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    106524934..106539858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344197.1XP_054200172.1  augurin isoform X1

    UniProtKB/TrEMBL
    C9JRR0
  2. XM_054344198.1XP_054200173.1  augurin isoform X2

    UniProtKB/TrEMBL
    B8ZZE5
  3. XM_054344199.1XP_054200174.1  augurin isoform X2

    UniProtKB/TrEMBL
    B8ZZE5