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CAVIN2 caveolae associated protein 2 [ Homo sapiens (human) ]

Gene ID: 8436, updated on 24-Nov-2020

Summary

Official Symbol
CAVIN2provided by HGNC
Official Full Name
caveolae associated protein 2provided by HGNC
Primary source
HGNC:HGNC:10690
See related
Ensembl:ENSG00000168497 MIM:606728
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR; SDPR; PS-p68; cavin-2
Summary
This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]
Expression
Broad expression in fat (RPKM 116.9), lung (RPKM 67.0) and 17 other tissues See more
Orthologs

Genomic context

See CAVIN2 in Genome Data Viewer
Location:
2q32.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (191834310..191847088, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (192699031..192712006, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373812 Neighboring gene hCG2045843 Neighboring gene Sharpr-MPRA regulatory region 6341 Neighboring gene Sharpr-MPRA regulatory region 2977

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
plasma membrane tubulation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
caveola IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
caveolae-associated protein 2
Names
phosphatidylserine-binding protein
serum deprivation response
serum deprivation-response protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004657.6NP_004648.1  caveolae-associated protein 2

    See identical proteins and their annotated locations for NP_004648.1

    Status: REVIEWED

    Source sequence(s)
    BC016475, BM971534, BQ025694, DA561006, R55388
    Consensus CDS
    CCDS2313.1
    UniProtKB/Swiss-Prot
    O95810
    Related
    ENSP00000305675.4, ENST00000304141.5
    Conserved Domains (1) summary
    pfam15237
    Location:53294
    PTRF_SDPR; PTRF/SDPR family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    191834310..191847088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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