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DYDC2 DPY30 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 84332, updated on 25-Nov-2021

Summary

Official Symbol
DYDC2provided by HGNC
Official Full Name
DPY30 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:23468
See related
Ensembl:ENSG00000133665
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of a family of proteins that contains a DPY30 domain. This gene locus overlaps with a closely related gene on the opposite strand. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Expression
Biased expression in testis (RPKM 6.0), lung (RPKM 1.3) and 1 other tissue See more
Orthologs
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Genomic context

See DYDC2 in Genome Data Viewer
Location:
10q23.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (80344745..80368073)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (82104501..82127829)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13640 Neighboring gene methionine adenosyltransferase 1A Neighboring gene zinc finger protein 519 pseudogene 1 Neighboring gene DPY30 domain containing 1 Neighboring gene peroxiredoxin like 2A Neighboring gene tetraspanin 14 Neighboring gene Sharpr-MPRA regulatory region 2609

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC16186

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in histone H3-K4 methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IEA
Inferred from Electronic Annotation
more info
 
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DPY30 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270041.2NP_001256970.1  DPY30 domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001256970.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC018606, DA590784
    Consensus CDS
    CCDS7367.1
    UniProtKB/Swiss-Prot
    Q96IM9
    Related
    ENSP00000483479.1, ENST00000616870.4
    Conserved Domains (1) summary
    pfam05186
    Location:141
    Dpy-30; Dpy-30 motif
  2. NM_001270042.2NP_001256971.1  DPY30 domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001256971.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' UTR splicing structure, and initiates translation at an alternate start codon, but maintains the reading frame, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    BC018606, BQ229460
    Consensus CDS
    CCDS58088.1
    UniProtKB/TrEMBL
    A0A0A0MRQ7
    Related
    ENSP00000361272.1, ENST00000372198.5
    Conserved Domains (1) summary
    pfam05186
    Location:1555
    Dpy-30; Dpy-30 motif
  3. NM_032372.6NP_115748.1  DPY30 domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_115748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AK093378, BC018606, DA590784
    Consensus CDS
    CCDS7367.1
    UniProtKB/Swiss-Prot
    Q96IM9
    Related
    ENSP00000256039.2, ENST00000256039.3
    Conserved Domains (1) summary
    pfam05186
    Location:141
    Dpy-30; Dpy-30 motif

RNA

  1. NR_070308.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC018606
  2. NR_070309.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC007374, BC018606

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    80344745..80368073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540270.2XP_011538572.1  DPY30 domain-containing protein 2 isoform X2

    Related
    ENSP00000401333.1, ENST00000411538.5
    Conserved Domains (1) summary
    pfam05186
    Location:141
    Dpy-30; Dpy-30 motif
  2. XM_011540267.2XP_011538569.1  DPY30 domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011538569.1

    UniProtKB/Swiss-Prot
    Q96IM9
    Conserved Domains (1) summary
    pfam05186
    Location:141
    Dpy-30; Dpy-30 motif
  3. XM_011540268.1XP_011538570.1  DPY30 domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011538570.1

    UniProtKB/Swiss-Prot
    Q96IM9
    Related
    ENSP00000361271.1, ENST00000372197.5
    Conserved Domains (1) summary
    pfam05186
    Location:141
    Dpy-30; Dpy-30 motif
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