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UTF1 undifferentiated embryonic cell transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 8433, updated on 17-Oct-2021

Summary

Official Symbol
UTF1provided by HGNC
Official Full Name
undifferentiated embryonic cell transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:12634
See related
Ensembl:ENSG00000171794 MIM:604130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See UTF1 in Genome Data Viewer
Location:
10q26.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (133230217..133231558)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135043721..135045062)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene kinase non-catalytic C-lobe domain containing 1 Neighboring gene uncharacterized LOC105378574 Neighboring gene uncharacterized LOC105378573 Neighboring gene VENT homeobox Neighboring gene MIR202 host gene Neighboring gene microRNA 202

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
undifferentiated embryonic cell transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003577.3NP_003568.2  undifferentiated embryonic cell transcription factor 1

    See identical proteins and their annotated locations for NP_003568.2

    Status: REVIEWED

    Source sequence(s)
    AL445199, AY606112
    Consensus CDS
    CCDS31318.1
    UniProtKB/Swiss-Prot
    Q5T230
    Related
    ENSP00000305906.2, ENST00000304477.3
    Conserved Domains (1) summary
    pfam13837
    Location:79134
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    133230217..133231558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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