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LZIC leucine zipper and CTNNBIP1 domain containing [ Homo sapiens (human) ]

Gene ID: 84328, updated on 11-Jun-2021

Summary

Official Symbol
LZICprovided by HGNC
Official Full Name
leucine zipper and CTNNBIP1 domain containingprovided by HGNC
Primary source
HGNC:HGNC:17497
See related
Ensembl:ENSG00000162441 MIM:610458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 8.7), colon (RPKM 7.1) and 25 other tissues See more
Orthologs
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Genomic context

See LZIC in Genome Data Viewer
Location:
1p36.22
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (9922118..9943402, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9982176..10003449, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene calsyntenin 1 Neighboring gene mitotic spindle organizing protein 1 pseudogene 1 Neighboring gene uncharacterized LOC105376717 Neighboring gene catenin beta interacting protein 1 Neighboring gene RN7SK pseudogene 269 Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene transmembrane protein 274, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15436

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein LZIC
Names
leucine zipper and CTNNBIP1 domain-containing protein
leucine zipper and ICAT homologous domain-containing protein
leucine zipper domain and ICAT homologous domain containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316973.2NP_001303902.1  protein LZIC isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK312550, AL357140, CB241987, DA538145
    Consensus CDS
    CCDS107.1
    UniProtKB/Swiss-Prot
    Q8WZA0
    UniProtKB/TrEMBL
    A0A024R4I7
    Related
    ENSP00000366418.1, ENST00000377213.1
    Conserved Domains (1) summary
    pfam06384
    Location:113188
    ICAT; Beta-catenin-interacting protein ICAT
  2. NM_001316974.2NP_001303903.1  protein LZIC isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice junctions in the 5' end compared to variant 1. The resulting isoform (b) is longer at the N-terminus compared to isoform a.
    Source sequence(s)
    AK304348, AL357140, CB241987, DA538145
    UniProtKB/Swiss-Prot
    Q8WZA0
    Conserved Domains (1) summary
    pfam06384
    Location:134209
    ICAT; Beta-catenin-interacting protein ICAT
  3. NM_001316975.2NP_001303904.1  protein LZIC isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate terminal exon compared to variant 1. The resulting isoform (c) has a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    BI772110, BQ018333, DA538145
    Related
    ENSP00000468610.1, ENST00000488540.5
    Conserved Domains (1) summary
    pfam06384
    Location:113172
    ICAT; Beta-catenin-interacting protein ICAT
  4. NM_001316976.2NP_001303905.1  protein LZIC isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks two alternate coding exons compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL357140, CB241987, DA538145, DB106543
    Conserved Domains (1) summary
    pfam04111
    Location:887
    APG6; Autophagy protein Apg6
  5. NM_032368.5NP_115744.2  protein LZIC isoform a

    See identical proteins and their annotated locations for NP_115744.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AA220235, AL357140, BC007240, CB241987
    Consensus CDS
    CCDS107.1
    UniProtKB/Swiss-Prot
    Q8WZA0
    UniProtKB/TrEMBL
    A0A024R4I7
    Related
    ENSP00000366430.1, ENST00000377223.6
    Conserved Domains (1) summary
    pfam06384
    Location:113188
    ICAT; Beta-catenin-interacting protein ICAT

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    9922118..9943402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263506.2XP_005263563.1  protein LZIC isoform X1

    See identical proteins and their annotated locations for XP_005263563.1

    Conserved Domains (1) summary
    pfam06384
    Location:113172
    ICAT; Beta-catenin-interacting protein ICAT
  2. XM_017002546.1XP_016858035.1  protein LZIC isoform X2

    Conserved Domains (2) summary
    pfam06384
    Location:113171
    ICAT; Beta-catenin-interacting protein ICAT
    pfam04111
    Location:887
    APG6; Autophagy protein Apg6
  3. XM_017002547.1XP_016858036.1  protein LZIC isoform X2

    Conserved Domains (2) summary
    pfam06384
    Location:113171
    ICAT; Beta-catenin-interacting protein ICAT
    pfam04111
    Location:887
    APG6; Autophagy protein Apg6
  4. XM_005263509.3XP_005263566.1  protein LZIC isoform X3

    See identical proteins and their annotated locations for XP_005263566.1

    Conserved Domains (1) summary
    pfam04111
    Location:887
    APG6; Autophagy protein Apg6
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