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LZIC leucine zipper and CTNNBIP1 domain containing [ Homo sapiens (human) ]

Gene ID: 84328, updated on 10-Dec-2024

Summary

Official Symbol
LZICprovided by HGNC
Official Full Name
leucine zipper and CTNNBIP1 domain containingprovided by HGNC
Primary source
HGNC:HGNC:17497
See related
Ensembl:ENSG00000162441 MIM:610458; AllianceGenome:HGNC:17497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable beta-catenin binding activity. Predicted to be involved in negative regulation of Wnt signaling pathway. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in testis (RPKM 8.7), colon (RPKM 7.1) and 25 other tissues See more
Orthologs
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Genomic context

See LZIC in Genome Data Viewer
Location:
1p36.22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9922118..9943391, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (9465032..9486296, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9982176..10003449, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9911316-9912116 Neighboring gene catenin beta interacting protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9919701-9920595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9931412-9932340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9932341-9933268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 236 Neighboring gene uncharacterized LOC124903838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9943986-9944775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9946851-9947439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9960261-9960762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9970922-9971595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9971596-9972268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9987872-9988381 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9990871-9991370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9998882-9999382 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:9999383-9999883 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:10002582-10003781 Neighboring gene RN7SK pseudogene 269 Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene transmembrane protein 274, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
protein LZIC
Names
leucine zipper and CTNNBIP1 domain-containing protein
leucine zipper and ICAT homologous domain-containing protein
leucine zipper domain and ICAT homologous domain containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316973.2NP_001303902.1  protein LZIC isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK312550, AL357140, CB241987, DA538145
    Consensus CDS
    CCDS107.1
    UniProtKB/Swiss-Prot
    B2R6F0, B4E2N0, Q8WZA0, Q96IU1
    Related
    ENSP00000366418.1, ENST00000377213.1
    Conserved Domains (1) summary
    pfam06384
    Location:113188
    ICAT; Beta-catenin-interacting protein ICAT
  2. NM_001316974.2NP_001303903.1  protein LZIC isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice junctions in the 5' end compared to variant 1. The resulting isoform (b) is longer at the N-terminus compared to isoform a.
    Source sequence(s)
    AK304348, AL357140, CB241987, DA538145
    UniProtKB/Swiss-Prot
    Q8WZA0
    Conserved Domains (1) summary
    pfam06384
    Location:134209
    ICAT; Beta-catenin-interacting protein ICAT
  3. NM_001316975.2NP_001303904.1  protein LZIC isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate terminal exon compared to variant 1. The resulting isoform (c) has a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    BI772110, BQ018333, DA538145
    UniProtKB/TrEMBL
    K7ES95
    Related
    ENSP00000468610.1, ENST00000488540.5
    Conserved Domains (1) summary
    pfam06384
    Location:113172
    ICAT; Beta-catenin-interacting protein ICAT
  4. NM_001316976.2NP_001303905.1  protein LZIC isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks two alternate coding exons compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL357140, CB241987, DA538145, DB106543
    Conserved Domains (1) summary
    pfam04111
    Location:887
    APG6; Autophagy protein Apg6
  5. NM_032368.5NP_115744.2  protein LZIC isoform a

    See identical proteins and their annotated locations for NP_115744.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AA220235, AL357140, BC007240, CB241987
    Consensus CDS
    CCDS107.1
    UniProtKB/Swiss-Prot
    B2R6F0, B4E2N0, Q8WZA0, Q96IU1
    Related
    ENSP00000366430.1, ENST00000377223.6
    Conserved Domains (1) summary
    pfam06384
    Location:113188
    ICAT; Beta-catenin-interacting protein ICAT

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    9922118..9943391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263506.3XP_005263563.1  protein LZIC isoform X1

    See identical proteins and their annotated locations for XP_005263563.1

    UniProtKB/TrEMBL
    K7ES95
    Conserved Domains (1) summary
    pfam06384
    Location:113172
    ICAT; Beta-catenin-interacting protein ICAT
  2. XM_017002546.2XP_016858035.1  protein LZIC isoform X2

    Conserved Domains (2) summary
    pfam06384
    Location:113171
    ICAT; Beta-catenin-interacting protein ICAT
    pfam04111
    Location:887
    APG6; Autophagy protein Apg6
  3. XM_017002547.2XP_016858036.1  protein LZIC isoform X2

    Conserved Domains (2) summary
    pfam06384
    Location:113171
    ICAT; Beta-catenin-interacting protein ICAT
    pfam04111
    Location:887
    APG6; Autophagy protein Apg6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    9465032..9486296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339191.1XP_054195166.1  protein LZIC isoform X1

    UniProtKB/TrEMBL
    K7ES95
  2. XM_054339193.1XP_054195168.1  protein LZIC isoform X2

  3. XM_054339192.1XP_054195167.1  protein LZIC isoform X2