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NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit [ Homo sapiens (human) ]

Gene ID: 84316, updated on 17-Jun-2019

Summary

Official Symbol
NAA38provided by HGNC
Official Full Name
N(alpha)-acetyltransferase 38, NatC auxiliary subunitprovided by HGNC
Primary source
HGNC:HGNC:28212
See related
Ensembl:ENSG00000183011 MIM:617990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LSMD1; MAK31; PFAAP2
Annotation information
Note: The name of this locus was changed from LSMD1 to NAA38 by the HUGO Gene Nomenclature Committee. [23 Jan 2014]
Expression
Ubiquitous expression in testis (RPKM 15.5), prostate (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See NAA38 in Genome Data Viewer
Location:
17p13.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7856681..7885420, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7760003..7788608, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene lysine demethylase 6B Neighboring gene uncharacterized LOC107987244 Neighboring gene Sharpr-MPRA regulatory region 4002 Neighboring gene transmembrane protein 88 Neighboring gene cytochrome b5 domain containing 1 Neighboring gene chromodomain helicase DNA binding protein 3 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene ring finger protein 227

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Retrograde transport at the Trans-Golgi-Network, organism-specific biosystem (from REACTOME)
    Retrograde transport at the Trans-Golgi-Network, organism-specific biosystemThe trans-Golgi network is the docking site for retrograde cargo from the endolysosomal system and the plasma membrane. Typical cargo includes recycling resident TGN proteins such as TGOLN2 (also kn...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14151, MGC74837

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
NatC complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with polysome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
N-alpha-acetyltransferase 38, NatC auxiliary subunit
Names
LSM domain containing 1
LSM domain-containing protein 1
phosphonoformate immuno-associated protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320924.2NP_001307853.1  N-alpha-acetyltransferase 38, NatC auxiliary subunit isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104581, BM817770
    Consensus CDS
    CCDS82059.1
    UniProtKB/TrEMBL
    I3L3Z2
    Related
    ENSP00000460841.2, ENST00000575071.5
    Conserved Domains (1) summary
    cd06168
    Location:42125
    LSMD1; LSM domain containing 1
  2. NM_001320925.2NP_001307854.1  N-alpha-acetyltransferase 38, NatC auxiliary subunit isoform 3

    Status: VALIDATED

    Source sequence(s)
    BC051846, BM817770
    Consensus CDS
    CCDS82060.1
    UniProtKB/Swiss-Prot
    Q9BRA0
    Related
    ENSP00000460172.2, ENST00000575771.5
    Conserved Domains (1) summary
    cd06168
    Location:42115
    LSMD1; LSM domain containing 1
  3. NM_001330111.2NP_001317040.1  N-alpha-acetyltransferase 38, NatC auxiliary subunit isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus and lacks a predicted signal peptide compared to isoform 1.
    Source sequence(s)
    AC104581, BM817770, BU941699, HY017333
    Consensus CDS
    CCDS82062.1
    UniProtKB/TrEMBL
    I3L4V0
    Related
    ENSP00000461545.1, ENST00000576861.5
  4. NM_032356.5NP_115732.2  N-alpha-acetyltransferase 38, NatC auxiliary subunit isoform 1 precursor

    See identical proteins and their annotated locations for NP_115732.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC033861, BC051846, BM817770
    Consensus CDS
    CCDS11122.1
    UniProtKB/Swiss-Prot
    Q9BRA0
    Related
    ENSP00000332103.5, ENST00000333775.9
    Conserved Domains (1) summary
    cd06168
    Location:90163
    LSMD1; LSM domain containing 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7856681..7885420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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