U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MRPL45 mitochondrial ribosomal protein L45 [ Homo sapiens (human) ]

Gene ID: 84311, updated on 27-Nov-2024

Summary

Official Symbol
MRPL45provided by HGNC
Official Full Name
mitochondrial ribosomal protein L45provided by HGNC
Primary source
HGNC:HGNC:16651
See related
Ensembl:ENSG00000278845 MIM:611850; AllianceGenome:HGNC:16651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mba1; mL45; L45mt; MRP-L45
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in thyroid (RPKM 16.2), kidney (RPKM 15.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MRPL45 in Genome Data Viewer
Location:
17q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38297168..38323211)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39160147..39186117)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36453134..36479094)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene NPEPPS pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36380303-36380804 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36399387-36399886 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36413044-36413577 Neighboring gene uncharacterized LOC105371760 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:36442025-36443224 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36452469-36453018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36453019-36453569 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36476257-36477193 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36488638-36489138 Neighboring gene G protein-coupled receptor 179 Neighboring gene NANOG hESC enhancer GRCh37_chr17:36497214-36497738 Neighboring gene uncharacterized LOC124903991

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
large ribosomal subunit protein mL45
Names
39S ribosomal protein L45, mitochondrial
mitochondrial large ribosomal subunit protein mL45

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278279.3NP_001265208.2  large ribosomal subunit protein mL45 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC244092, AK293605, BC006235, BI767984, BP374871
    Consensus CDS
    CCDS74047.1
    UniProtKB/TrEMBL
    A0A087WU62, A0A0G2JMS5
    Related
    ENSP00000478397.1, ENST00000619548.1
    Conserved Domains (1) summary
    cl09208
    Location:119212
    Tim44; Tim44-like domain
  2. NM_032351.6NP_115727.5  large ribosomal subunit protein mL45 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK293605, BC006235
    Consensus CDS
    CCDS11326.1
    UniProtKB/Swiss-Prot
    A1L436, Q6ZMJ5, Q9BRJ2
    UniProtKB/TrEMBL
    A0A087X2D5
    Related
    ENSP00000484903.1, ENST00000613675.5
    Conserved Domains (1) summary
    smart00978
    Location:121262
    Tim44; Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    38297168..38323211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2332199..2358159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    39160147..39186117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)