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PYM1 PYM homolog 1, exon junction complex associated factor [ Homo sapiens (human) ]

Gene ID: 84305, updated on 2-Mar-2021

Summary

Official Symbol
PYM1provided by HGNC
Official Full Name
PYM homolog 1, exon junction complex associated factorprovided by HGNC
Primary source
HGNC:HGNC:30258
See related
Ensembl:ENSG00000170473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PYM; WIBG
Expression
Ubiquitous expression in esophagus (RPKM 16.0), colon (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

See PYM1 in Genome Data Viewer
Location:
12q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (55901413..55927894, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56295197..56321678, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 676, pseudogene Neighboring gene glutathione S-transferase pi 1 pseudogene 1 Neighboring gene diacylglycerol kinase alpha Neighboring gene premelanosome protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13064

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
exon-exon junction complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exon-exon junction complex disassembly IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
exon-exon junction complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exon-exon junction complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
partner of Y14 and mago
Names
protein wibg homolog
within bgcn homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143853.1NP_001137325.1  partner of Y14 and mago isoform 2

    See identical proteins and their annotated locations for NP_001137325.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is 1 aa shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC006135, BC014976, DB466388
    Consensus CDS
    CCDS44916.1
    UniProtKB/Swiss-Prot
    Q9BRP8
    Related
    ENSP00000381271.4, ENST00000398213.4
    Conserved Domains (1) summary
    pfam09282
    Location:1137
    Mago-bind; Mago binding
  2. NM_032345.3NP_115721.1  partner of Y14 and mago isoform 1

    See identical proteins and their annotated locations for NP_115721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC023055, AC025162
    Consensus CDS
    CCDS41795.1
    UniProtKB/Swiss-Prot
    Q9BRP8
    Related
    ENSP00000386156.2, ENST00000408946.7
    Conserved Domains (1) summary
    pfam09282
    Location:1438
    Mago-bind; Mago binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    55901413..55927894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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