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EIF1AD eukaryotic translation initiation factor 1A domain containing [ Homo sapiens (human) ]

Gene ID: 84285, updated on 21-Dec-2019

Summary

Official Symbol
EIF1ADprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 1A domain containingprovided by HGNC
Primary source
HGNC:HGNC:28147
See related
Ensembl:ENSG00000175376 MIM:618473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OBELIX; haponin
Expression
Ubiquitous expression in bone marrow (RPKM 7.6), testis (RPKM 6.0) and 25 other tissues See more
Orthologs

Genomic context

See EIF1AD in Genome Data Viewer
Location:
11q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65996545..66002217, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65764016..65769637, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 pseudogene Neighboring gene BAF nuclear assembly factor 1 Neighboring gene cystatin E/M Neighboring gene cation channel sperm associated 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC11102

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable RNA-binding protein EIF1AD
Names
eukaryotic translation initiation factor 1A domain-containing protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242481.2NP_001229410.1  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_001229410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AI831454, AP006287, BE669813, BE791453, BP328412
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    Q8N9N8
    UniProtKB/TrEMBL
    A0A024R5B9
    Related
    ENSP00000434056.1, ENST00000533544.6
    Conserved Domains (1) summary
    cd05792
    Location:25102
    S1_eIF1AD_like; S1_eIF1AD_like: eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found ...
  2. NM_001242482.2NP_001229411.1  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_001229411.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1, but encodes the same protein.
    Source sequence(s)
    AP006287, BE669813, BE791453, BP328412, BU790195
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    Q8N9N8
    UniProtKB/TrEMBL
    A0A024R5B9
    Related
    ENSP00000435439.1, ENST00000527249.5
    Conserved Domains (1) summary
    cd05792
    Location:25102
    S1_eIF1AD_like; S1_eIF1AD_like: eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found ...
  3. NM_001242483.2NP_001229412.1  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_001229412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 1, but encodes the same protein.
    Source sequence(s)
    AP006287, AW872373, BE669813, BE791453, BP328412
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    Q8N9N8
    UniProtKB/TrEMBL
    A0A024R5B9
    Conserved Domains (1) summary
    cd05792
    Location:25102
    S1_eIF1AD_like; S1_eIF1AD_like: eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found ...
  4. NM_001242484.2NP_001229413.1  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_001229413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, compared to variant 1, but encodes the same protein.
    Source sequence(s)
    AP006287, BE669813, DA024526
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    Q8N9N8
    UniProtKB/TrEMBL
    A0A024R5B9
    Conserved Domains (1) summary
    cd05792
    Location:25102
    S1_eIF1AD_like; S1_eIF1AD_like: eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found ...
  5. NM_001242485.2NP_001229414.1  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_001229414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses multiple alternate splice sites in the 5' UTR, compared to variant 1, but encodes the same protein.
    Source sequence(s)
    AP006287, BC005131, BG149615, BP328412
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    Q8N9N8
    UniProtKB/TrEMBL
    A0A024R5B9
    Related
    ENSP00000436644.1, ENST00000526451.5
    Conserved Domains (1) summary
    cd05792
    Location:25102
    S1_eIF1AD_like; S1_eIF1AD_like: eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found ...
  6. NM_001242486.2NP_001229415.1  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_001229415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses multiple alternate splice sites in the 5' UTR, compared to variant 1, but encodes the same protein.
    Source sequence(s)
    AP006287, BP328412
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    Q8N9N8
    UniProtKB/TrEMBL
    A0A024R5B9
    Related
    ENSP00000435942.2, ENST00000529964.5
    Conserved Domains (1) summary
    cd05792
    Location:25102
    S1_eIF1AD_like; S1_eIF1AD_like: eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found ...
  7. NM_032325.4NP_115701.2  probable RNA-binding protein EIF1AD

    See identical proteins and their annotated locations for NP_115701.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1, but encodes the same protein.
    Source sequence(s)
    AK311891, AP006287, BP328412
    Consensus CDS
    CCDS8124.1
    UniProtKB/Swiss-Prot
    Q8N9N8
    UniProtKB/TrEMBL
    A0A024R5B9
    Related
    ENSP00000309175.2, ENST00000312234.6
    Conserved Domains (1) summary
    cd05792
    Location:25102
    S1_eIF1AD_like; S1_eIF1AD_like: eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65996545..66002217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018412.2XP_016873901.1  probable RNA-binding protein EIF1AD isoform X1

    UniProtKB/Swiss-Prot
    Q8N9N8
    UniProtKB/TrEMBL
    A0A024R5B9
    Conserved Domains (1) summary
    cd05792
    Location:25102
    S1_eIF1AD_like; S1_eIF1AD_like: eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found ...
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