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SLC25A33 solute carrier family 25 member 33 [ Homo sapiens (human) ]

Gene ID: 84275, updated on 23-Nov-2023

Summary

Official Symbol
SLC25A33provided by HGNC
Official Full Name
solute carrier family 25 member 33provided by HGNC
Primary source
HGNC:HGNC:29681
See related
Ensembl:ENSG00000171612 MIM:610816; AllianceGenome:HGNC:29681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PNC1; BMSC-MCP
Summary
SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 27.8), fat (RPKM 18.2) and 23 other tissues See more
Orthologs
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Genomic context

See SLC25A33 in Genome Data Viewer
Location:
1p36.22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9539465..9585173)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (9075801..9121512)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9599524..9645231)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9487788-9488422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 128 Neighboring gene long intergenic non-protein coding RNA 2606 Neighboring gene RNA, 5S ribosomal pseudogene 40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9533371-9533922 Neighboring gene MPRA-validated peak54 silencer Neighboring gene Sharpr-MPRA regulatory region 9854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9601405-9601904 Neighboring gene MPRA-validated peak56 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 223 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 225 Neighboring gene hESC enhancers GRCh37_chr1:9653469-9654066 and GRCh37_chr1:9654067-9654663 Neighboring gene ribosomal protein L9 pseudogene 11 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:9657808-9659007 Neighboring gene transmembrane protein 201 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:9671778-9672013 Neighboring gene uncharacterized LOC124903837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9675483-9676027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 226 Neighboring gene nonconserved acetylation island sequence 67 enhancer Neighboring gene uncharacterized LOC105376712 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC4399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables pyrimidine nucleotide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyrimidine nucleotide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to insulin-like growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondria-nucleus signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrial genome maintenance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial genome maintenance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial respiratory chain complex III assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pyrimidine nucleotide import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pyrimidine nucleotide import into mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pyrimidine nucleotide import into mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pyrimidine nucleotide transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitochondrial membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
solute carrier family 25 member 33
Names
bone marrow stromal cell mitochondrial carrier protein
huBMSC-MCP
mitochondrial carrier protein
novel mitochondrial carrier protein
solute carrier family 25 (pyrimidine nucleotide carrier), member 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032315.3NP_115691.1  solute carrier family 25 member 33

    See identical proteins and their annotated locations for NP_115691.1

    Status: VALIDATED

    Source sequence(s)
    AL928921, AL954705, BC004991, BC073135
    Consensus CDS
    CCDS103.1
    UniProtKB/Swiss-Prot
    Q9BSK2
    Related
    ENSP00000306328.5, ENST00000302692.7
    Conserved Domains (1) summary
    pfam00153
    Location:7123
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    9539465..9585173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    9075801..9121512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)