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SLC25A33 solute carrier family 25 member 33 [ Homo sapiens (human) ]

Gene ID: 84275, updated on 12-Oct-2019

Summary

Official Symbol
SLC25A33provided by HGNC
Official Full Name
solute carrier family 25 member 33provided by HGNC
Primary source
HGNC:HGNC:29681
See related
Ensembl:ENSG00000171612 MIM:610816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PNC1; BMSC-MCP
Summary
SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 27.8), fat (RPKM 18.2) and 23 other tissues See more
Orthologs

Genomic context

See SLC25A33 in Genome Data Viewer
Location:
1p36.22
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (9539465..9585173)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9599528..9642831)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2606 Neighboring gene RNA, 5S ribosomal pseudogene 40 Neighboring gene ribosomal protein L9 pseudogene 11 Neighboring gene Sharpr-MPRA regulatory region 8288 Neighboring gene transmembrane protein 201 Neighboring gene uncharacterized LOC107985734

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
pyrimidine nucleotide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyrimidine nucleotide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to insulin-like growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
mitochondria-nucleus signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial genome maintenance IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial respiratory chain complex III assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion organization IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
pyrimidine nucleotide import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyrimidine nucleotide import into mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
pyrimidine nucleotide import into mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
pyrimidine nucleotide transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrial membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
solute carrier family 25 member 33
Names
PNC1 protein
bone marrow stromal cell mitochondrial carrier protein
huBMSC-MCP
mitochondrial carrier protein
novel mitochondrial carrier protein
solute carrier family 25 (pyrimidine nucleotide carrier), member 33

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032315.3NP_115691.1  solute carrier family 25 member 33

    See identical proteins and their annotated locations for NP_115691.1

    Status: VALIDATED

    Source sequence(s)
    AL928921, AL954705, BC004991, BC073135
    Consensus CDS
    CCDS103.1
    UniProtKB/Swiss-Prot
    Q9BSK2
    Related
    ENSP00000306328.5, ENST00000302692.7
    Conserved Domains (2) summary
    PTZ00169
    Location:5317
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:7123
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    9539465..9585173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542296.1XP_011540598.1  solute carrier family 25 member 33 isoform X1

    See identical proteins and their annotated locations for XP_011540598.1

    Conserved Domains (1) summary
    pfam00153
    Location:62153
    Mito_carr; Mitochondrial carrier protein
  2. XM_005263503.4XP_005263560.1  solute carrier family 25 member 33 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:58149
    Mito_carr; Mitochondrial carrier protein
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