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PSMG3 proteasome assembly chaperone 3 [ Homo sapiens (human) ]

Gene ID: 84262, updated on 1-Jun-2020

Summary

Official Symbol
PSMG3provided by HGNC
Official Full Name
proteasome assembly chaperone 3provided by HGNC
Primary source
HGNC:HGNC:22420
See related
Ensembl:ENSG00000157778 MIM:617528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAC3; C7orf48
Expression
Ubiquitous expression in bone marrow (RPKM 8.7), skin (RPKM 6.6) and 25 other tissues See more
Orthologs

Genomic context

See PSMG3 in Genome Data Viewer
Location:
7p22.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (1567332..1570490, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1606968..1609668, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128653 Neighboring gene Sharpr-MPRA regulatory region 13805 Neighboring gene MAF bZIP transcription factor K Neighboring gene transmembrane protein 184A Neighboring gene PSMG3 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105375122 Neighboring gene uncharacterized LOC105375123

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10911

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
chaperone-mediated protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
proteasome assembly chaperone 3
Names
PAC-3
hPAC3
proteasome (prosome, macropain) assembly chaperone 3
proteasome assembling chaperone 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134340.2NP_001127812.1  proteasome assembly chaperone 3

    See identical proteins and their annotated locations for NP_001127812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BM825255, CN261807
    Consensus CDS
    CCDS5327.1
    UniProtKB/Swiss-Prot
    Q9BT73
    UniProtKB/TrEMBL
    A0A024R806
    Related
    ENSP00000384799.3, ENST00000404674.7
    Conserved Domains (1) summary
    pfam10178
    Location:34117
    PAC3; Proteasome assembly chaperone 3
  2. NM_032302.4NP_115678.1  proteasome assembly chaperone 3

    See identical proteins and their annotated locations for NP_115678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC093734, BC027171, CN261807
    Consensus CDS
    CCDS5327.1
    UniProtKB/Swiss-Prot
    Q9BT73
    UniProtKB/TrEMBL
    A0A024R806
    Related
    ENSP00000288607.2, ENST00000288607.3
    Conserved Domains (1) summary
    pfam10178
    Location:34117
    PAC3; Proteasome assembly chaperone 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    1567332..1570490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446976.1XP_024302744.1  proteasome assembly chaperone 3 isoform X1

    Related
    ENSP00000252329.3, ENST00000252329.3
    Conserved Domains (1) summary
    pfam10178
    Location:34117
    PAC3; Proteasome assembly chaperone 3
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