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DRC7 dynein regulatory complex subunit 7 [ Homo sapiens (human) ]

Gene ID: 84229, updated on 17-Jun-2019

Summary

Official Symbol
DRC7provided by HGNC
Official Full Name
dynein regulatory complex subunit 7provided by HGNC
Primary source
HGNC:HGNC:25289
See related
Ensembl:ENSG00000159625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAP50; CFAP50; CCDC135; C16orf50
Expression
Restricted expression toward testis (RPKM 24.8) See more
Orthologs

Genomic context

See DRC7 in Genome Data Viewer
Location:
16q21
Exon count:
19
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (57694806..57731805)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57728713..57765367)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371291 Neighboring gene high mobility group box 3 pseudogene 32 Neighboring gene adhesion G protein-coupled receptor G1 Neighboring gene adhesion G protein-coupled receptor G3 Neighboring gene mitochondrial carrier 2 pseudogene Neighboring gene uncharacterized LOC107984852 Neighboring gene Sharpr-MPRA regulatory region 7942 Neighboring gene katanin regulatory subunit B1 Neighboring gene Sharpr-MPRA regulatory region 7405

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434I099

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dynein regulatory complex subunit 7
Names
coiled-coil domain containing 135
coiled-coil domain-containing protein 135
coiled-coil domain-containing protein lobo homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289162.2NP_001276091.1  dynein regulatory complex subunit 7 isoform a

    See identical proteins and their annotated locations for NP_001276091.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC018552, AK093035, AK292558, BC030661, BC036667, DB093780
    Consensus CDS
    CCDS10787.1
    UniProtKB/Swiss-Prot
    Q8IY82
    Related
    ENSP00000353942.3, ENST00000360716.7
    Conserved Domains (1) summary
    pfam01841
    Location:173210
    Transglut_core; Transglutaminase-like superfamily
  2. NM_001289163.2NP_001276092.1  dynein regulatory complex subunit 7 isoform b

    See identical proteins and their annotated locations for NP_001276092.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AC018552, AK093035, BC036667, DB093780
    Consensus CDS
    CCDS73894.1
    UniProtKB/Swiss-Prot
    Q8IY82
    Related
    ENSP00000338938.8, ENST00000336825.12
  3. NM_032269.6NP_115645.4  dynein regulatory complex subunit 7 isoform a

    See identical proteins and their annotated locations for NP_115645.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC018552, AK292558, BC036667
    Consensus CDS
    CCDS10787.1
    UniProtKB/Swiss-Prot
    Q8IY82
    Related
    ENSP00000377869.4, ENST00000394337.8
    Conserved Domains (1) summary
    pfam01841
    Location:173210
    Transglut_core; Transglutaminase-like superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    57694806..57731805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523377.1XP_011521679.1  dynein regulatory complex subunit 7 isoform X1

    Conserved Domains (1) summary
    pfam01841
    Location:173210
    Transglut_core; Transglutaminase-like superfamily
  2. XM_011523378.1XP_011521680.1  dynein regulatory complex subunit 7 isoform X2

    See identical proteins and their annotated locations for XP_011521680.1

    UniProtKB/Swiss-Prot
    Q8IY82
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