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SPATC1L spermatogenesis and centriole associated 1 like [ Homo sapiens (human) ]

Gene ID: 84221, updated on 5-Aug-2022

Summary

Official Symbol
SPATC1Lprovided by HGNC
Official Full Name
spermatogenesis and centriole associated 1 likeprovided by HGNC
Primary source
HGNC:HGNC:1298
See related
Ensembl:ENSG00000160284 MIM:612412; AllianceGenome:HGNC:1298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C21orf56
Summary
Enables identical protein binding activity. Predicted to act upstream of or within several processes, including actin polymerization or depolymerization; positive regulation of cAMP-dependent protein kinase activity; and positive regulation of protein kinase A signaling. Predicted to be located in sperm connecting piece. Predicted to be active in centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 5.7), prostate (RPKM 2.7) and 22 other tissues See more
Orthologs
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Genomic context

Location:
21q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (46161160..46184459, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (44540975..44566185, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (47581074..47604373, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene collagen type VI alpha 2 chain Neighboring gene uncharacterized LOC124905043 Neighboring gene formimidoyltransferase cyclodeaminase Neighboring gene FTCD antisense RNA 1 Neighboring gene uncharacterized LOC124905045 Neighboring gene small nucleolar RNA, C/D box 159 Neighboring gene lanosterol synthase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99490, DKFZp434N0650

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A regulatory subunit binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in positive regulation of cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein kinase A signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sperm connecting piece IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
speriolin-like protein
Names
spermatogenesis and centriole-associated protein 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142854.2NP_001136326.1  speriolin-like protein isoform 1

    See identical proteins and their annotated locations for NP_001136326.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK304535, AP001468, AW138006
    Consensus CDS
    CCDS46653.1
    UniProtKB/Swiss-Prot
    Q9H0A9, Q9NSE5
    Related
    ENSP00000291672.5, ENST00000291672.6
    Conserved Domains (2) summary
    pfam15058
    Location:6153
    Speriolin_N; Speriolin N terminus
    pfam15059
    Location:195340
    Speriolin_C; Speriolin C-terminus
  2. NM_032261.5NP_115637.3  speriolin-like protein isoform 2

    See identical proteins and their annotated locations for NP_115637.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, compared to variant 1, which results in the use of a downstream in-frame start codon and a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK304535, AW138006
    Consensus CDS
    CCDS13732.1
    UniProtKB/Swiss-Prot
    Q9H0A9
    Related
    ENSP00000333869.6, ENST00000330205.10
    Conserved Domains (1) summary
    pfam15059
    Location:41186
    Speriolin_C; Speriolin C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    46161160..46184459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261188.6XP_005261245.1  speriolin-like protein isoform X1

    See identical proteins and their annotated locations for XP_005261245.1

    UniProtKB/Swiss-Prot
    Q9H0A9, Q9NSE5
    Conserved Domains (2) summary
    pfam15058
    Location:6153
    Speriolin_N; Speriolin N terminus
    pfam15059
    Location:195340
    Speriolin_C; Speriolin C-terminus
  2. XM_011529756.3XP_011528058.1  speriolin-like protein isoform X2

    See identical proteins and their annotated locations for XP_011528058.1

    Conserved Domains (1) summary
    pfam15059
    Location:81226
    Speriolin_C; Speriolin C-terminus

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187626.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    20597..45829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    44540975..44566185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)