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SETD3 SET domain containing 3, actin histidine methyltransferase [ Homo sapiens (human) ]

Gene ID: 84193, updated on 24-May-2020

Summary

Official Symbol
SETD3provided by HGNC
Official Full Name
SET domain containing 3, actin histidine methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:20493
See related
Ensembl:ENSG00000183576 MIM:615671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hSETD3; C14orf154
Expression
Ubiquitous expression in testis (RPKM 33.6), kidney (RPKM 26.5) and 25 other tissues See more
Orthologs

Genomic context

See SETD3 in Genome Data Viewer
Location:
14q32.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (99397746..99486458, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (99864083..99947228, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370660 Neighboring gene Sharpr-MPRA regulatory region 7827 Neighboring gene RNA, U6 small nuclear 91, pseudogene Neighboring gene cyclin K Neighboring gene coiled-coil domain containing 85C Neighboring gene uncharacterized LOC105370661 Neighboring gene HNF4 motif-containing MPRA enhancer 184

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23027, MGC87236, DKFZp761E1415

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II activating transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
histone methyltransferase activity (H3-K36 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone methyltransferase activity (H3-K36 specific) ISS
Inferred from Sequence or Structural Similarity
more info
 
histone methyltransferase activity (H3-K4 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-histidine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
actin modification IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-K36 methylation ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3-K4 methylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-histidine methylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-lysine dimethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-lysine dimethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-lysine monomethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-lysine monomethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT peptidyl-lysine trimethylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-lysine trimethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of uterine smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
actin-histidine N-methyltransferase
Names
SET domain containing 3
SET domain-containing protein 3
histone-lysine N-methyltransferase setd3
NP_115609.2
NP_954574.1
XP_005268184.1
XP_011535533.2
XP_011535534.1
XP_011535535.1
XP_011535536.1
XP_011535537.1
XP_016877188.1
XP_016877189.1
XP_016877190.1
XP_016877191.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032233.3NP_115609.2  actin-histidine N-methyltransferase isoform a

    See identical proteins and their annotated locations for NP_115609.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK026680, BC037395, BX161471, CB988965
    Consensus CDS
    CCDS9951.1
    UniProtKB/Swiss-Prot
    Q86TU7
    UniProtKB/TrEMBL
    A0A024R6K3
    Related
    ENSP00000327436.5, ENST00000331768.10
    Conserved Domains (2) summary
    pfam00856
    Location:105197
    SET; SET domain
    pfam09273
    Location:353475
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  2. NM_199123.2NP_954574.1  actin-histidine N-methyltransferase isoform b

    See identical proteins and their annotated locations for NP_954574.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a unique C-terminus compared to isoform a.
    Source sequence(s)
    BC009054, CB988965
    Consensus CDS
    CCDS9952.1
    UniProtKB/Swiss-Prot
    Q86TU7
    Related
    ENSP00000327910.3, ENST00000329331.7
    Conserved Domains (1) summary
    pfam00856
    Location:105197
    SET; SET domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    99397746..99486458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537233.2XP_011535535.1  actin-histidine N-methyltransferase isoform X2

    Conserved Domains (2) summary
    pfam00856
    Location:105256
    SET; SET domain
    pfam09273
    Location:295417
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  2. XM_011537231.2XP_011535533.2  actin-histidine N-methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q86TU7
    UniProtKB/TrEMBL
    A0A024R6K3
    Conserved Domains (2) summary
    pfam00856
    Location:105197
    SET; SET domain
    pfam09273
    Location:353475
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  3. XM_005268127.3XP_005268184.1  actin-histidine N-methyltransferase isoform X3

    See identical proteins and their annotated locations for XP_005268184.1

    Conserved Domains (2) summary
    pfam00856
    Location:176215
    SET; SET domain
    pfam09273
    Location:254376
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  4. XM_017021701.1XP_016877190.1  actin-histidine N-methyltransferase isoform X2

    Conserved Domains (2) summary
    pfam00856
    Location:105256
    SET; SET domain
    pfam09273
    Location:295417
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  5. XM_017021702.1XP_016877191.1  actin-histidine N-methyltransferase isoform X4

  6. XM_011537234.1XP_011535536.1  actin-histidine N-methyltransferase isoform X3

    See identical proteins and their annotated locations for XP_011535536.1

    Conserved Domains (2) summary
    pfam00856
    Location:176215
    SET; SET domain
    pfam09273
    Location:254376
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  7. XM_017021699.1XP_016877188.1  actin-histidine N-methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q86TU7
    UniProtKB/TrEMBL
    A0A024R6K3
    Conserved Domains (2) summary
    pfam00856
    Location:105197
    SET; SET domain
    pfam09273
    Location:353475
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  8. XM_011537232.3XP_011535534.1  actin-histidine N-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011535534.1

    UniProtKB/Swiss-Prot
    Q86TU7
    UniProtKB/TrEMBL
    A0A024R6K3
    Conserved Domains (2) summary
    pfam00856
    Location:105197
    SET; SET domain
    pfam09273
    Location:353475
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  9. XM_017021700.1XP_016877189.1  actin-histidine N-methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q86TU7
    UniProtKB/TrEMBL
    A0A024R6K3
    Conserved Domains (2) summary
    pfam00856
    Location:105197
    SET; SET domain
    pfam09273
    Location:353475
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  10. XM_011537235.1XP_011535537.1  actin-histidine N-methyltransferase isoform X5

    See identical proteins and their annotated locations for XP_011535537.1

    UniProtKB/Swiss-Prot
    Q86TU7
    Conserved Domains (1) summary
    pfam00856
    Location:105197
    SET; SET domain
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