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SETD3 SET domain containing 3, actin histidine methyltransferase [ Homo sapiens (human) ]

Gene ID: 84193, updated on 23-Nov-2021

Summary

Official Symbol
SETD3provided by HGNC
Official Full Name
SET domain containing 3, actin histidine methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:20493
See related
Ensembl:ENSG00000183576 MIM:615671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hSETD3; C14orf154
Expression
Ubiquitous expression in testis (RPKM 33.6), kidney (RPKM 26.5) and 25 other tissues See more
Orthologs
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Genomic context

See SETD3 in Genome Data Viewer
Location:
14q32.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (99397746..99486458, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (99864085..99947196, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370660 Neighboring gene Sharpr-MPRA regulatory region 7827 Neighboring gene RNA, U6 small nuclear 91, pseudogene Neighboring gene cyclin K Neighboring gene coiled-coil domain containing 85C Neighboring gene uncharacterized LOC105370661 Neighboring gene HNF4 motif-containing MPRA enhancer 184

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23027, MGC87236, DKFZp761E1415

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables histone methyltransferase activity (H3-K36 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone methyltransferase activity (H3-K36 specific) ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone methyltransferase activity (H3-K4 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-L-histidine N-tele-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in actin modification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H3-K36 methylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in histone H3-K4 methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-histidine methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-lysine dimethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-lysine dimethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-lysine monomethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-lysine monomethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in peptidyl-lysine trimethylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-lysine trimethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of uterine smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
actin-histidine N-methyltransferase
Names
SET domain-containing protein 3
histone-lysine N-methyltransferase setd3
protein-L-histidine N-tele-methyltransferase
NP_115609.2
NP_954574.1
XP_005268184.1
XP_011535533.2
XP_011535534.1
XP_011535535.1
XP_011535536.1
XP_011535537.1
XP_016877188.1
XP_016877189.1
XP_016877190.1
XP_016877191.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032233.3NP_115609.2  actin-histidine N-methyltransferase isoform a

    See identical proteins and their annotated locations for NP_115609.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK026680, BC037395, BX161471, CB988965
    Consensus CDS
    CCDS9951.1
    UniProtKB/Swiss-Prot
    Q86TU7
    UniProtKB/TrEMBL
    A0A024R6K3
    Related
    ENSP00000327436.5, ENST00000331768.10
    Conserved Domains (2) summary
    cd19176
    Location:80329
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
    pfam09273
    Location:350475
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  2. NM_199123.2NP_954574.1  actin-histidine N-methyltransferase isoform b

    See identical proteins and their annotated locations for NP_954574.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a unique C-terminus compared to isoform a.
    Source sequence(s)
    BC009054, CB988965
    Consensus CDS
    CCDS9952.1
    UniProtKB/Swiss-Prot
    Q86TU7
    Related
    ENSP00000327910.3, ENST00000329331.7
    Conserved Domains (1) summary
    cd19176
    Location:80282
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    99397746..99486458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537233.2XP_011535535.1  actin-histidine N-methyltransferase isoform X2

    Conserved Domains (2) summary
    pfam09273
    Location:292417
    Rubis-subs-bind; Rubisco LSMT substrate-binding
    cd19176
    Location:80271
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
  2. XM_011537231.2XP_011535533.2  actin-histidine N-methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q86TU7
    UniProtKB/TrEMBL
    A0A024R6K3
    Conserved Domains (2) summary
    cd19176
    Location:80329
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
    pfam09273
    Location:350475
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  3. XM_005268127.3XP_005268184.1  actin-histidine N-methyltransferase isoform X3

    See identical proteins and their annotated locations for XP_005268184.1

    Conserved Domains (2) summary
    pfam09273
    Location:251376
    Rubis-subs-bind; Rubisco LSMT substrate-binding
    cd19176
    Location:16230
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
  4. XM_017021701.1XP_016877190.1  actin-histidine N-methyltransferase isoform X2

    Conserved Domains (2) summary
    pfam09273
    Location:292417
    Rubis-subs-bind; Rubisco LSMT substrate-binding
    cd19176
    Location:80271
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
  5. XM_017021702.1XP_016877191.1  actin-histidine N-methyltransferase isoform X4

    Conserved Domains (2) summary
    pfam09273
    Location:193318
    Rubis-subs-bind; Rubisco LSMT substrate-binding
    cd19176
    Location:16172
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
  6. XM_011537234.1XP_011535536.1  actin-histidine N-methyltransferase isoform X3

    See identical proteins and their annotated locations for XP_011535536.1

    Conserved Domains (2) summary
    pfam09273
    Location:251376
    Rubis-subs-bind; Rubisco LSMT substrate-binding
    cd19176
    Location:16230
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
  7. XM_017021699.1XP_016877188.1  actin-histidine N-methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q86TU7
    UniProtKB/TrEMBL
    A0A024R6K3
    Conserved Domains (2) summary
    cd19176
    Location:80329
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
    pfam09273
    Location:350475
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  8. XM_011537232.3XP_011535534.1  actin-histidine N-methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011535534.1

    UniProtKB/Swiss-Prot
    Q86TU7
    UniProtKB/TrEMBL
    A0A024R6K3
    Conserved Domains (2) summary
    cd19176
    Location:80329
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
    pfam09273
    Location:350475
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  9. XM_017021700.1XP_016877189.1  actin-histidine N-methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q86TU7
    UniProtKB/TrEMBL
    A0A024R6K3
    Conserved Domains (2) summary
    cd19176
    Location:80329
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
    pfam09273
    Location:350475
    Rubis-subs-bind; Rubisco LSMT substrate-binding
  10. XM_011537235.1XP_011535537.1  actin-histidine N-methyltransferase isoform X5

    See identical proteins and their annotated locations for XP_011535537.1

    UniProtKB/Swiss-Prot
    Q86TU7
    Conserved Domains (1) summary
    cd19176
    Location:80282
    SET_SETD3; SET domain found in SET domain-containing protein 3 (SETD3) and similar proteins
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