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ZCCHC7 zinc finger CCHC-type containing 7 [ Homo sapiens (human) ]

Gene ID: 84186, updated on 7-Jan-2024

Summary

Official Symbol
ZCCHC7provided by HGNC
Official Full Name
zinc finger CCHC-type containing 7provided by HGNC
Primary source
HGNC:HGNC:26209
See related
Ensembl:ENSG00000147905 AllianceGenome:HGNC:26209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIR1; HSPC086
Summary
Enables RNA binding activity. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 3.6), testis (RPKM 2.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZCCHC7 in Genome Data Viewer
Location:
9p13.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (37120167..37358149)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (37143909..37381876)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37120469..37358146)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:37053864-37054416 Neighboring gene MPRA-validated peak7233 silencer Neighboring gene ribosomal protein L32 pseudogene 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28377 Neighboring gene endogenous Bornavirus like nucleoprotein 3, pseudogene Neighboring gene uncharacterized LOC105376034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28378 Neighboring gene NANOG hESC enhancer GRCh37_chr9:37149770-37150271 Neighboring gene uncharacterized LOC105376033 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:37184571-37185145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28380 Neighboring gene Sharpr-MPRA regulatory region 4584 Neighboring gene ZCCHC7 intron homotypic cluster of transcription factor binding sites enhancer Neighboring gene NANOG hESC enhancer GRCh37_chr9:37226199-37226700 Neighboring gene Sharpr-MPRA regulatory region 4537 Neighboring gene VISTA enhancer hs901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28382 Neighboring gene RNA, U6 small nuclear 677, pseudogene Neighboring gene uncharacterized LOC124902153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:37385483-37385983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28389 Neighboring gene Sharpr-MPRA regulatory region 4136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28390 Neighboring gene long intergenic non-protein coding RNA 1627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28391 Neighboring gene uncharacterized LOC124902154 Neighboring gene uncharacterized LOC105376035

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ22611

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of TRAMP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger CCHC domain-containing protein 7
Names
TRAMP-like complex RNA-binding factor ZCCHC7
zinc finger, CCHC domain containing 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289119.2NP_001276048.1  zinc finger CCHC domain-containing protein 7

    See identical proteins and their annotated locations for NP_001276048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    BC005990, BC034022, BC036940
    Consensus CDS
    CCDS6608.2
    UniProtKB/Swiss-Prot
    B2RCI4, D3DRQ0, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N3Z6, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0
    Conserved Domains (1) summary
    COG5082
    Location:238379
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
  2. NM_001289120.2NP_001276049.1  zinc finger CCHC domain-containing protein 7

    See identical proteins and their annotated locations for NP_001276049.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK074608, AK315128, AL512604, BC036940, BP216150
    Consensus CDS
    CCDS6608.2
    UniProtKB/Swiss-Prot
    B2RCI4, D3DRQ0, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N3Z6, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0
    Conserved Domains (1) summary
    COG5082
    Location:238379
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
  3. NM_001289121.2NP_001276050.1  zinc finger CCHC domain-containing protein 7

    See identical proteins and their annotated locations for NP_001276050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AL158155, AL512604, BC036940, BP216150
    Consensus CDS
    CCDS6608.2
    UniProtKB/Swiss-Prot
    B2RCI4, D3DRQ0, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N3Z6, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0
    Related
    ENSP00000443113.2, ENST00000534928.5
    Conserved Domains (1) summary
    COG5082
    Location:238379
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
  4. NM_032226.3NP_115602.2  zinc finger CCHC domain-containing protein 7

    See identical proteins and their annotated locations for NP_115602.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AI458621, AK026264, AL158155, BC005990, BP246540
    Consensus CDS
    CCDS6608.2
    UniProtKB/Swiss-Prot
    B2RCI4, D3DRQ0, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N3Z6, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0
    Related
    ENSP00000337839.5, ENST00000336755.10
    Conserved Domains (1) summary
    COG5082
    Location:238379
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RNA

  1. NR_110317.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK026264, AK074608, AK303193, BC036940, BP246540

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    37120167..37358149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251612.4XP_005251669.1  zinc finger CCHC domain-containing protein 7 isoform X1

    See identical proteins and their annotated locations for XP_005251669.1

    UniProtKB/Swiss-Prot
    B2RCI4, D3DRQ0, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N3Z6, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0
    Conserved Domains (1) summary
    COG5082
    Location:238379
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
  2. XM_024447691.2XP_024303459.1  zinc finger CCHC domain-containing protein 7 isoform X4

    Conserved Domains (1) summary
    cl26705
    Location:40181
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
  3. XM_011518050.3XP_011516352.1  zinc finger CCHC domain-containing protein 7 isoform X2

    Conserved Domains (1) summary
    COG5082
    Location:238326
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
  4. XM_017015199.3XP_016870688.1  zinc finger CCHC domain-containing protein 7 isoform X4

    Conserved Domains (1) summary
    cl26705
    Location:40181
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
  5. XM_005251608.5XP_005251665.1  zinc finger CCHC domain-containing protein 7 isoform X1

    See identical proteins and their annotated locations for XP_005251665.1

    UniProtKB/Swiss-Prot
    B2RCI4, D3DRQ0, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N3Z6, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0
    Conserved Domains (1) summary
    COG5082
    Location:238379
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
  6. XM_017015198.2XP_016870687.1  zinc finger CCHC domain-containing protein 7 isoform X2

    Conserved Domains (1) summary
    COG5082
    Location:238326
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
  7. XM_047423958.1XP_047279914.1  zinc finger CCHC domain-containing protein 7 isoform X2

  8. XM_017015200.2XP_016870689.1  zinc finger CCHC domain-containing protein 7 isoform X4

    Conserved Domains (1) summary
    cl26705
    Location:40181
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
  9. XM_017015197.2XP_016870686.1  zinc finger CCHC domain-containing protein 7 isoform X2

    Conserved Domains (1) summary
    COG5082
    Location:238326
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
  10. XM_047423960.1XP_047279916.1  zinc finger CCHC domain-containing protein 7 isoform X4

  11. XM_047423957.1XP_047279913.1  zinc finger CCHC domain-containing protein 7 isoform X2

  12. XM_047423959.1XP_047279915.1  zinc finger CCHC domain-containing protein 7 isoform X4

  13. XM_047423962.1XP_047279918.1  zinc finger CCHC domain-containing protein 7 isoform X5

    UniProtKB/TrEMBL
    B4E024
  14. XM_011518051.3XP_011516353.1  zinc finger CCHC domain-containing protein 7 isoform X3

    Conserved Domains (1) summary
    COG5082
    Location:44185
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    37143909..37381876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363953.1XP_054219928.1  zinc finger CCHC domain-containing protein 7 isoform X1

    UniProtKB/Swiss-Prot
    B2RCI4, D3DRQ0, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N3Z6, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0
  2. XM_054363964.1XP_054219939.1  zinc finger CCHC domain-containing protein 7 isoform X4

  3. XM_054363955.1XP_054219930.1  zinc finger CCHC domain-containing protein 7 isoform X2

  4. XM_054363962.1XP_054219937.1  zinc finger CCHC domain-containing protein 7 isoform X4

  5. XM_054363954.1XP_054219929.1  zinc finger CCHC domain-containing protein 7 isoform X1

    UniProtKB/Swiss-Prot
    B2RCI4, D3DRQ0, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N3Z6, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0
  6. XM_054363957.1XP_054219932.1  zinc finger CCHC domain-containing protein 7 isoform X2

  7. XM_054363959.1XP_054219934.1  zinc finger CCHC domain-containing protein 7 isoform X2

  8. XM_054363963.1XP_054219938.1  zinc finger CCHC domain-containing protein 7 isoform X4

  9. XM_054363958.1XP_054219933.1  zinc finger CCHC domain-containing protein 7 isoform X2

  10. XM_054363965.1XP_054219940.1  zinc finger CCHC domain-containing protein 7 isoform X4

  11. XM_054363956.1XP_054219931.1  zinc finger CCHC domain-containing protein 7 isoform X2

  12. XM_054363961.1XP_054219936.1  zinc finger CCHC domain-containing protein 7 isoform X4

  13. XM_054363966.1XP_054219941.1  zinc finger CCHC domain-containing protein 7 isoform X5

    UniProtKB/TrEMBL
    B4E024
  14. XM_054363960.1XP_054219935.1  zinc finger CCHC domain-containing protein 7 isoform X3