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PPP1R1B protein phosphatase 1 regulatory inhibitor subunit 1B [ Homo sapiens (human) ]

Gene ID: 84152, updated on 1-Jun-2020

Summary

Official Symbol
PPP1R1Bprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 1Bprovided by HGNC
Primary source
HGNC:HGNC:9287
See related
Ensembl:ENSG00000131771 MIM:604399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DARPP32; DARPP-32
Summary
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in colon (RPKM 51.4), salivary gland (RPKM 45.0) and 11 other tissues See more
Orthologs

Genomic context

See PPP1R1B in Genome Data Viewer
Location:
17q12
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (39626735..39636625)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37783177..37792878)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene neuronal differentiation 2 Neighboring gene VISTA enhancer hs627 Neighboring gene StAR related lipid transfer domain containing 3 Neighboring gene titin-cap

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D1 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
D2 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
D3 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
D4 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
D5 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protein phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protein phosphatase regulator activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of female receptivity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
response to nicotine IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine head IEA
Inferred from Electronic Annotation
more info
 
dendritic spine neck IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 1B
Names
dopamine and cAMP-regulated neuronal phosphoprotein 32
NP_001229393.1
NP_115568.2
NP_852606.1
XP_016880705.1
XP_016880706.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030330.1 RefSeqGene

    Range
    5029..14701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242464.2NP_001229393.1  protein phosphatase 1 regulatory subunit 1B isoform 2

    See identical proteins and their annotated locations for NP_001229393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 3 encode isoform 2
    Source sequence(s)
    AF435973, AY070271
    Consensus CDS
    CCDS11340.1
    UniProtKB/Swiss-Prot
    Q9UD71
    UniProtKB/TrEMBL
    A0A024R1R3
    Related
    ENSP00000377808.1, ENST00000394265.5
    Conserved Domains (1) summary
    pfam05395
    Location:176
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32
  2. NM_032192.4NP_115568.2  protein phosphatase 1 regulatory subunit 1B isoform 1

    See identical proteins and their annotated locations for NP_115568.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF464196
    Consensus CDS
    CCDS11339.1
    UniProtKB/Swiss-Prot
    Q9UD71
    UniProtKB/TrEMBL
    B3KVQ9
    Related
    ENSP00000254079.4, ENST00000254079.9
    Conserved Domains (1) summary
    pfam05395
    Location:2112
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32
  3. NM_181505.4NP_852606.1  protein phosphatase 1 regulatory subunit 1B isoform 2

    See identical proteins and their annotated locations for NP_852606.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 3 encode isoform 2.
    Source sequence(s)
    AY070271
    Consensus CDS
    CCDS11340.1
    UniProtKB/Swiss-Prot
    Q9UD71
    UniProtKB/TrEMBL
    A0A024R1R3
    Related
    ENSP00000377810.2, ENST00000394267.2
    Conserved Domains (1) summary
    pfam05395
    Location:176
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    39626735..39636625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025216.2XP_016880705.1  protein phosphatase 1 regulatory subunit 1B isoform X1

    UniProtKB/Swiss-Prot
    Q9UD71
    UniProtKB/TrEMBL
    B3KVQ9
    Related
    ENSP00000462137.1, ENST00000580825.5
    Conserved Domains (1) summary
    pfam05395
    Location:2112
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32
  2. XM_017025217.2XP_016880706.1  protein phosphatase 1 regulatory subunit 1B isoform X2

    UniProtKB/Swiss-Prot
    Q9UD71
    UniProtKB/TrEMBL
    A0A024R1R3
    Conserved Domains (1) summary
    pfam05395
    Location:176
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32
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