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BCAR3 BCAR3 adaptor protein, NSP family member [ Homo sapiens (human) ]

Gene ID: 8412, updated on 2-Mar-2021

Summary

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Official Symbol
BCAR3provided by HGNC
Official Full Name
BCAR3 adaptor protein, NSP family memberprovided by HGNC
Primary source
HGNC:HGNC:973
See related
Ensembl:ENSG00000137936 MIM:604704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIG7; NSP2; AND-34; SH2D3B
Summary
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in fat (RPKM 13.8), placenta (RPKM 6.5) and 23 other tissues See more
Orthologs
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Genomic context

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See BCAR3 in Genome Data Viewer
Location:
1p22.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (93561741..93847219, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (94027298..94312775, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene formin binding protein 1 like Neighboring gene RNA, 5S ribosomal pseudogene 53 Neighboring gene tRNA-Cys (anticodon GCA) 7-1 Neighboring gene BCAR3 antisense RNA 1 Neighboring gene uncharacterized LOC102723480 Neighboring gene tRNA-Arg (anticodon TCT) 1-1 Neighboring gene microRNA 760 Neighboring gene deoxynucleotidyltransferase terminal interacting protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Silencing of Mig-7 expression inhibits in-vitro invasiveness and vasculogenic mimicry of human glioma U87 Cells. Pan Z, et al. Neuroreport, 2019 Dec 10. PMID 31688418
  2. [Mig-7 gene silencing inhibits vasculogenic mimicry formation and invasion of glioma U251 cells in vitro by suppressing MEK/ERK signaling]. Wang F, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2019 May 30. PMID 31140421, Free PMC Article
  3. Prediction and prognostic significance of BCAR3 expression in patients with multiple myeloma. Zhang W, et al. J Transl Med, 2018 Dec 18. PMID 30563570, Free PMC Article
  4. Migration-inducing gene-7 independently predicts poor prognosis of human osteosarcoma and is associated with vasculogenic mimicry. Ren K, et al. Exp Cell Res, 2018 Aug 1. PMID 29750896
  5. MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma. Qu B, et al. Oncol Rep, 2018 Feb. PMID 29251318

See all (64) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MIG-7 mRNA expression may serve as an additional molecular marker of vasculogenic mimicry in ovarian malignancies.
    Title: Mig-7 expression and vasculogenic mimicry in malignant ovarian tumors.
  2. Study provides evidence that MIG7 expression in hepatocellular carcinoma (HCC) tissue is correlated positively with vasculogenic mimicry (VM) formation and MIG7 expression in different HCC cell lines is coincident with their VM formation, invasion and metastasis.
    Title: MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma.
  3. this study indicates that the expression of Mig-7 in gliomas is positively correlated with vasculogenic mimicry formation and is related to the glioma pathological grade
    Title: Silencing of Mig-7 expression inhibits in-vitro invasiveness and vasculogenic mimicry of human glioma U87 Cells.
  4. MIG-7 serves as an independent unfavorable prognostic indicator in osteosarcoma patients and MIG-7 is an important mediator of osteosarcoma Vascular Mimicry formation.
    Title: Migration-inducing gene-7 independently predicts poor prognosis of human osteosarcoma and is associated with vasculogenic mimicry.
  5. The high expressions of Mig-7 and MMP-2 in gastric carcinoma tissues may have a synergistic promoting effect on VM formation. VM is closely associated with the invasion, metastasis and poor prognosis of gastric carcinoma.
    Title: [Expressions and clinical significance of vasculogenic mimicry and related protein Mig-7 and MMP-2 in gastric carcinoma].
  6. MIG7 expression in hepatocellular carcinoma tissue is high and correlated positively with vasculogenic mimicry formation, invasion and metastasis.
    Title: [MIG7 Regulates the Vasculogenic Mimicry Formation in Hepatocellular Carcinoma then Effects the Metastasis Potential of HCC].
  7. Silencing of Mig-7 gene inhibits vasculogenic mimicry formation and invasion of U251 cells possibly by suppressing MEK/ERK signaling, suggesting the important role of Mig-7 gene in vasculogenic mimicry formation and invasion of human glioma cells
    Title: [Mig-<i>7</i> gene silencing inhibits vasculogenic mimicry formation and invasion of glioma U251 cells <i>in vitro</i> by suppressing MEK/ERK signaling].
  8. Inhibiting MIG-7 by RNA interference in grafted EOC cells retarded tumor growth, angiogenesis and improved host survival, and suppressing MIG-7 expression with a small molecule inhibitor D-39 identified from the mitigated EOC growth and invasion and specifically abrogated the expression of vascular endothelial growth factor.
    Title: Migration-inducing gene 7 promotes tumorigenesis and angiogenesis and independently predicts poor prognosis of epithelial ovarian cancer.
  9. miR-126-5p negatively regulated BCAR3 expression in eutopic endometriosis, enhanced the migration and invasion of endometrial cells, and promoted the occurrence of endometriosis.
    Title: MicroRNA-126-5p downregulates BCAR3 expression to promote cell migration and invasion in endometriosis.
  10. high expression level of BCAR3 predicted better prognosis of multiple myeloma patients.
    Title: Prediction and prognostic significance of BCAR3 expression in patients with multiple myeloma.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0554

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
phosphotyrosine residue binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
endothelin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
lens morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
  
positive regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
response to drug TAS
Traceable Author Statement
more info
 PubMed 
signal transduction TAS
Traceable Author Statement
more info
 PubMed 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
  
focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
breast cancer anti-estrogen resistance protein 3
Names
BCAR3, NSP family adaptor protein
SH2 domain-containing protein 3B
breast cancer anti-estrogen resistance 3
breast cancer antiestrogen resistance 3 protein
dJ1033H22.2 (breast cancer anti-estrogen resistance 3)
epididymis secretory sperm binding protein
mig-7
migration inducting gene-7
novel SH2-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261408.2 → NP_001248337.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001248337.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AL049796, AL109613, BC028477, BQ015705
    Consensus CDS
    CCDS745.1
    UniProtKB/Swiss-Prot
    O75815
    Related
    ENSP00000359264.1, ENST00000370244.5
    Conserved Domains (2) summary
    cd10337
    Location:147 → 282
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:544 → 819
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  2. NM_001261409.1 → NP_001248338.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001248338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK027785, AK055442, BQ015705, DA745974
    Consensus CDS
    CCDS745.1
    UniProtKB/Swiss-Prot
    O75815
    UniProtKB/TrEMBL
    B3KNL6, B3KP06
    Related
    ENSP00000359263.1, ENST00000370243.1
    Conserved Domains (2) summary
    cd10337
    Location:147 → 282
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:544 → 819
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  3. NM_001261410.2 → NP_001248339.1  breast cancer anti-estrogen resistance protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001248339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL109613, AL833121, BQ015705
    Consensus CDS
    CCDS58010.1
    UniProtKB/Swiss-Prot
    O75815
    Related
    ENSP00000359267.3, ENST00000370247.7
    Conserved Domains (2) summary
    cd10337
    Location:56 → 191
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:453 → 728
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  4. NM_001308251.1 → NP_001295180.1  breast cancer anti-estrogen resistance protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001295180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a significantly shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK310970, AW470748, AY358996
    Consensus CDS
    CCDS76181.1
    UniProtKB/Swiss-Prot
    O75815
    Related
    ENSP00000441343.1, ENST00000539242.5
    Conserved Domains (1) summary
    smart00147
    Location:220 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  5. NM_003567.4 → NP_003558.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    See identical proteins and their annotated locations for NP_003558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AF124250, AL109613, BQ015705, CN337133
    Consensus CDS
    CCDS745.1
    UniProtKB/Swiss-Prot
    O75815
    Related
    ENSP00000260502.6, ENST00000260502.11
    Conserved Domains (2) summary
    cd10337
    Location:147 → 282
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:544 → 819
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

RNA

  1. NR_171551.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    93561741..93847219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002480.1 → XP_016857969.1  breast cancer anti-estrogen resistance protein 3 isoform X1

    UniProtKB/Swiss-Prot
    O75815
    Conserved Domains (2) summary
    cd10337
    Location:147 → 282
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:544 → 819
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75815.1 GenPept UniProtKB/Swiss-Prot:O75815

Gene LinkOut

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