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BCAR3 BCAR3 adaptor protein, NSP family member [ Homo sapiens (human) ]

Gene ID: 8412, updated on 9-Nov-2022

Summary

Official Symbol
BCAR3provided by HGNC
Official Full Name
BCAR3 adaptor protein, NSP family memberprovided by HGNC
Primary source
HGNC:HGNC:973
See related
Ensembl:ENSG00000137936 MIM:604704; AllianceGenome:HGNC:973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIG7; NSP2; AND-34; SH2D3B
Summary
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in fat (RPKM 13.8), placenta (RPKM 6.5) and 23 other tissues See more
Orthologs
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Genomic context

See BCAR3 in Genome Data Viewer
Location:
1p22.1
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (93561741..93847219, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (93407475..93692966, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (94027298..94312775, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene formin binding protein 1 like Neighboring gene tRNA-Cys (anticodon GCA) 7-1 Neighboring gene Sharpr-MPRA regulatory region 13550 Neighboring gene BCAR3 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 755 Neighboring gene Sharpr-MPRA regulatory region 8830 Neighboring gene uncharacterized LOC102723480 Neighboring gene Sharpr-MPRA regulatory region 5000 Neighboring gene Sharpr-MPRA regulatory region 10321 Neighboring gene uncharacterized LOC124904220 Neighboring gene tRNA-Arg (anticodon TCT) 1-1 Neighboring gene microRNA 760 Neighboring gene deoxynucleotidyltransferase terminal interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0554

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphotyrosine residue binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
breast cancer anti-estrogen resistance protein 3
Names
BCAR3, NSP family adaptor protein
SH2 domain-containing protein 3B
breast cancer anti-estrogen resistance 3
breast cancer antiestrogen resistance 3 protein
dJ1033H22.2 (breast cancer anti-estrogen resistance 3)
epididymis secretory sperm binding protein
mig-7
migration inducting gene-7
novel SH2-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261408.2NP_001248337.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001248337.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AL049796, AL109613, BC028477, BQ015705
    Consensus CDS
    CCDS745.1
    UniProtKB/Swiss-Prot
    O75815, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3
    Related
    ENSP00000359264.1, ENST00000370244.5
    Conserved Domains (2) summary
    cd10337
    Location:147282
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:544819
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
  2. NM_001261409.1NP_001248338.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001248338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AK027785, AK055442, BQ015705, DA745974
    Consensus CDS
    CCDS745.1
    UniProtKB/Swiss-Prot
    O75815, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3, B3KNL6, B3KP06
    Related
    ENSP00000359263.1, ENST00000370243.1
    Conserved Domains (2) summary
    cd10337
    Location:147282
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:544819
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
  3. NM_001261410.2NP_001248339.1  breast cancer anti-estrogen resistance protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001248339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL109613, AL833121, BQ015705
    Consensus CDS
    CCDS58010.1
    UniProtKB/Swiss-Prot
    O75815
    Related
    ENSP00000359267.3, ENST00000370247.7
    Conserved Domains (2) summary
    cd10337
    Location:56191
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:453728
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
  4. NM_001308251.1NP_001295180.1  breast cancer anti-estrogen resistance protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001295180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a significantly shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK310970, AW470748, AY358996
    Consensus CDS
    CCDS76181.1
    UniProtKB/Swiss-Prot
    O75815
    Related
    ENSP00000441343.1, ENST00000539242.5
    Conserved Domains (1) summary
    smart00147
    Location:220495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
  5. NM_001412043.1NP_001398972.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
    UniProtKB/Swiss-Prot
    Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3
  6. NM_001412044.1NP_001398973.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
    UniProtKB/Swiss-Prot
    Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3
  7. NM_001412045.1NP_001398974.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
    UniProtKB/Swiss-Prot
    Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3
  8. NM_001412046.1NP_001398975.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
    UniProtKB/Swiss-Prot
    Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3
  9. NM_001412048.1NP_001398977.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
    UniProtKB/Swiss-Prot
    Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3
  10. NM_001412049.1NP_001398978.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
    UniProtKB/Swiss-Prot
    Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3
  11. NM_001412050.1NP_001398979.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
    UniProtKB/Swiss-Prot
    Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3
  12. NM_001412051.1NP_001398980.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
    UniProtKB/Swiss-Prot
    Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3
  13. NM_001412052.1NP_001398981.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
    UniProtKB/Swiss-Prot
    Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3
  14. NM_001412054.1NP_001398983.1  breast cancer anti-estrogen resistance protein 3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
  15. NM_001412055.1NP_001398984.1  breast cancer anti-estrogen resistance protein 3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
  16. NM_001412056.1NP_001398985.1  breast cancer anti-estrogen resistance protein 3 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL109613, AL359820
  17. NM_001412057.1NP_001398986.1  breast cancer anti-estrogen resistance protein 3 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
  18. NM_001412058.1NP_001398987.1  breast cancer anti-estrogen resistance protein 3 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
    UniProtKB/TrEMBL
    B3KNL6
  19. NM_001412059.1NP_001398988.1  breast cancer anti-estrogen resistance protein 3 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
  20. NM_001412060.1NP_001398989.1  breast cancer anti-estrogen resistance protein 3 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
  21. NM_001412061.1NP_001398990.1  breast cancer anti-estrogen resistance protein 3 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
  22. NM_001412062.1NP_001398991.1  breast cancer anti-estrogen resistance protein 3 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
  23. NM_001412064.1NP_001398993.1  breast cancer anti-estrogen resistance protein 3 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
  24. NM_001412065.1NP_001398994.1  breast cancer anti-estrogen resistance protein 3 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
  25. NM_001412066.1NP_001398995.1  breast cancer anti-estrogen resistance protein 3 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
  26. NM_001412067.1NP_001398996.1  breast cancer anti-estrogen resistance protein 3 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
  27. NM_001412072.1NP_001399001.1  breast cancer anti-estrogen resistance protein 3 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
  28. NM_001412073.1NP_001399002.1  breast cancer anti-estrogen resistance protein 3 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
  29. NM_001412074.1NP_001399003.1  breast cancer anti-estrogen resistance protein 3 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL109613
  30. NM_001412075.1NP_001399004.1  breast cancer anti-estrogen resistance protein 3 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL109613
  31. NM_001412076.1NP_001399005.1  breast cancer anti-estrogen resistance protein 3 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL109613
  32. NM_001412077.1NP_001399006.1  breast cancer anti-estrogen resistance protein 3 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL109613
    UniProtKB/TrEMBL
    B3KNL6
  33. NM_003567.4NP_003558.1  breast cancer anti-estrogen resistance protein 3 isoform 1

    See identical proteins and their annotated locations for NP_003558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AF124250, AL109613, BQ015705, CN337133
    Consensus CDS
    CCDS745.1
    UniProtKB/Swiss-Prot
    O75815, Q9BR50
    UniProtKB/TrEMBL
    A0A384MTS3
    Related
    ENSP00000260502.6, ENST00000260502.11
    Conserved Domains (2) summary
    cd10337
    Location:147282
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    smart00147
    Location:544819
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

RNA

  1. NR_148965.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488
  2. NR_171551.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488
  3. NR_178002.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796
  4. NR_178003.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488
  5. NR_178005.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796
  6. NR_178006.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488
  7. NR_178007.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796
  8. NR_178009.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796
  9. NR_178010.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488
  10. NR_178011.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488
  11. NR_178013.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL359820
  12. NR_178014.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796
  13. NR_178015.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796
  14. NR_178016.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL359820
  15. NR_178017.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488
  16. NR_178018.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488
  17. NR_178021.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488
  18. NR_178022.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL049796, AL512488
  19. NR_178023.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820
  20. NR_178024.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL109613, AL359820

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    93561741..93847219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    93407475..93692966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)