Format

Send to:

Choose Destination

SLC10A7 solute carrier family 10 member 7 [ Homo sapiens (human) ]

Gene ID: 84068, updated on 26-Oct-2021

Summary

Official Symbol
SLC10A7provided by HGNC
Official Full Name
solute carrier family 10 member 7provided by HGNC
Primary source
HGNC:HGNC:23088
See related
Ensembl:ENSG00000120519 MIM:611459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P7; SSASKS; C4orf13
Expression
Ubiquitous expression in placenta (RPKM 1.0), stomach (RPKM 1.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SLC10A7 in Genome Data Viewer
Location:
4q31.22
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (146253981..146522351, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (147175133..147443092, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene reeler domain containing 1 Neighboring gene uncharacterized LOC105377472 Neighboring gene microRNA 7849 Neighboring gene RNA, U1 small nuclear 44, pseudogene Neighboring gene POU class 4 homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
GeneReviews: Not available
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
GeneReviews: Not available
Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis
MedGen: C5193055 OMIM: 618363 GeneReviews: Not available
Compare labs

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25043, DKFZp566M114, DKFZp313H0531, DKFZp779O2438

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi vesicle transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in bile acid and bile salt transport IEA
Inferred from Electronic Annotation
more info
 
involved_in bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycoprotein transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heparin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi medial cisterna IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sodium/bile acid cotransporter 7
Names
Na(+)/bile acid cotransporter 7
SBF-domain containing protein
solute carrier family 10 (sodium/bile acid cotransporter family), member 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029998.6NP_001025169.1  sodium/bile acid cotransporter 7 isoform b

    See identical proteins and their annotated locations for NP_001025169.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes isoform b.
    Source sequence(s)
    AC093863, BC150308
    Consensus CDS
    CCDS34073.1
    UniProtKB/Swiss-Prot
    Q0GE19
    Related
    ENSP00000334594.8, ENST00000335472.12
    Conserved Domains (1) summary
    pfam13593
    Location:10320
    SBF_like; SBF-like CPA transporter family (DUF4137)
  2. NM_001300842.3NP_001287771.1  sodium/bile acid cotransporter 7 isoform d

    See identical proteins and their annotated locations for NP_001287771.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 3' coding region, compared to variant 2. The encoded isoform (d) has a longer and distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AC093863, BC150308, DA590625, DQ871036
    Consensus CDS
    CCDS75198.1
    UniProtKB/Swiss-Prot
    Q0GE19
    Related
    ENSP00000421275.1, ENST00000507030.5
    Conserved Domains (1) summary
    pfam13593
    Location:10320
    SBF_like; SBF-like CPA transporter family (DUF4137)
  3. NM_001317816.2NP_001304745.1  sodium/bile acid cotransporter 7 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the central coding region, compared to variant 2. The encoded isoform (e) has the same N- and C-termini, but is shorter than isoform b.
    Source sequence(s)
    AC093863, BC150308, CR933647
    Consensus CDS
    CCDS82963.1
    UniProtKB/Swiss-Prot
    Q0GE19
    Related
    ENSP00000411297.2, ENST00000432059.6
    Conserved Domains (1) summary
    pfam13593
    Location:10307
    SBF_like; SBF-like CPA transporter family (DUF4137)
  4. NM_001317817.2NP_001304746.1  sodium/bile acid cotransporter 7 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks many exons and its 3'-terminal exon extends past a splice site that is used in variant 2. The encoded isoform (f) has a significantly shorter and distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AC106879, AL136728, BC120971, DB205503
    Consensus CDS
    CCDS82962.1
    UniProtKB/Swiss-Prot
    Q0GE19
    Related
    ENSP00000421603.1, ENST00000511374.5
    Conserved Domains (1) summary
    cl19217
    Location:1075
    SBF; Sodium Bile acid symporter family
  5. NM_001317818.2NP_001304747.1  sodium/bile acid cotransporter 7 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks many exons and its 3'-terminal exon extends past a splice site that is used in variant 2. The encoded isoform (g) has a significantly shorter and distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AC106879, BC023288, DA590625
    Consensus CDS
    CCDS82964.1
    UniProtKB/Swiss-Prot
    Q0GE19
    Related
    ENSP00000422577.1, ENST00000502607.1
    Conserved Domains (1) summary
    cl19217
    Location:1063
    SBF; Sodium Bile acid symporter family
  6. NM_032128.5NP_115504.1  sodium/bile acid cotransporter 7 isoform c

    See identical proteins and their annotated locations for NP_115504.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 2. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AC106879, AL136728, BC127626, DB205503
    Consensus CDS
    CCDS3768.1
    UniProtKB/Swiss-Prot
    Q0GE19
    Related
    ENSP00000377623.4, ENST00000394059.8
    Conserved Domains (1) summary
    cl19217
    Location:10145
    SBF; Sodium Bile acid symporter family

RNA

  1. NR_133924.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks two consecutive alternate internal exons, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093863, BC150308, DA590625, DQ122861

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    146253981..146522351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532311.2XP_011530613.1  sodium/bile acid cotransporter 7 isoform X1

    See identical proteins and their annotated locations for XP_011530613.1

    Conserved Domains (1) summary
    pfam13593
    Location:10307
    SBF_like; SBF-like CPA transporter family (DUF4137)
  2. XM_011532313.2XP_011530615.1  sodium/bile acid cotransporter 7 isoform X2

    Conserved Domains (1) summary
    cl19217
    Location:1207
    SBF; Sodium Bile acid symporter family
  3. XM_011532314.2XP_011530616.1  sodium/bile acid cotransporter 7 isoform X3

    Conserved Domains (1) summary
    cl19217
    Location:16190
    SBF; Sodium Bile acid symporter family
  4. XM_017008692.1XP_016864181.1  sodium/bile acid cotransporter 7 isoform X7

    UniProtKB/Swiss-Prot
    Q0GE19
    Conserved Domains (1) summary
    cl19217
    Location:1075
    SBF; Sodium Bile acid symporter family
  5. XM_017008690.2XP_016864179.1  sodium/bile acid cotransporter 7 isoform X5

  6. XM_017008691.2XP_016864180.1  sodium/bile acid cotransporter 7 isoform X6

  7. XM_017008689.1XP_016864178.1  sodium/bile acid cotransporter 7 isoform X4

RNA

  1. XR_001741332.2 RNA Sequence

  2. XR_938780.3 RNA Sequence

  3. XR_001741333.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001030316.1: Suppressed sequence

    Description
    NM_001030316.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center