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Mmp1a matrix metallopeptidase 1a (interstitial collagenase) [ Mus musculus (house mouse) ]

Gene ID: 83995, updated on 26-Sep-2022

Summary

Official Symbol
Mmp1aprovided by MGI
Official Full Name
matrix metallopeptidase 1a (interstitial collagenase)provided by MGI
Primary source
MGI:MGI:1933846
See related
Ensembl:ENSMUSG00000043089 AllianceGenome:MGI:1933846
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mcola; MMP-1a; Mcol-A
Summary
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens. Mice lacking the encoded protein exhibit decreased susceptibility to chemical carcinogen-induced lung tumor development and angiogenesis. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]
Expression
Restricted expression toward placenta adult (RPKM 3.5) See more
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Genomic context

See Mmp1a in Genome Data Viewer
Location:
9; 9 A1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7464141..7476870)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7464141..7476869)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 1b (interstitial collagenase) Neighboring gene matrix metallopeptidase 3 Neighboring gene matrix metallopeptidase 10 Neighboring gene predicted gene, 31751 Neighboring gene matrix metallopeptidase 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interstitial collagenase A
Names
collagenase-like A
matrix metalloproteinase 1a (interstitial collagenase)
NP_114395.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032006.3NP_114395.1  interstitial collagenase A preproprotein

    See identical proteins and their annotated locations for NP_114395.1

    Status: REVIEWED

    Source sequence(s)
    AK049552, BQ558168
    UniProtKB/Swiss-Prot
    Q149J4, Q9EPL5
    Related
    ENSMUSP00000151193.3, ENSMUST00000217651.3
    Conserved Domains (4) summary
    cd00094
    Location:273464
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:105259
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:105259
    Peptidase_M10; Matrixin
    pfam01471
    Location:2684
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    7464141..7476870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)