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Tssk6 testis-specific serine kinase 6 [ Mus musculus (house mouse) ]

Gene ID: 83984, updated on 18-Apr-2024

Summary

Official Symbol
Tssk6provided by MGI
Official Full Name
testis-specific serine kinase 6provided by MGI
Primary source
MGI:MGI:2148775
See related
Ensembl:ENSMUSG00000047654 AllianceGenome:MGI:2148775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sstk; TSK-6; TSSK-6
Summary
Enables magnesium ion binding activity and protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and sperm chromatin condensation. Orthologous to human TSSK6 (testis specific serine kinase 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
8 B3.3; 8 34.05 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70354834..70356168)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69902184..69903518)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33746 Neighboring gene cartilage intermediate layer protein 2 Neighboring gene YjeF N-terminal domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E10503 Neighboring gene STARR-positive B cell enhancer ABC_E1757 Neighboring gene NADH:ubiquinone oxidoreductase subunit A13 Neighboring gene GATA zinc finger domain containing 2A Neighboring gene STARR-positive B cell enhancer ABC_E5012 Neighboring gene STARR-positive B cell enhancer ABC_E1367 Neighboring gene STARR-seq mESC enhancer starr_21753 Neighboring gene STARR-seq mESC enhancer starr_21758 Neighboring gene STARR-positive B cell enhancer ABC_E89 Neighboring gene STARR-seq mESC enhancer starr_21762 Neighboring gene nucleoside diphosphate kinase B pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in sperm DNA condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
testis-specific serine/threonine-protein kinase 6
Names
serine/threonine protein kinase SSTK
small serine/threonine kinase
testis-specific kinase 6
NP_114393.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032004.2NP_114393.1  testis-specific serine/threonine-protein kinase 6

    See identical proteins and their annotated locations for NP_114393.1

    Status: VALIDATED

    Source sequence(s)
    AC158564, AF329484
    Consensus CDS
    CCDS22354.1
    UniProtKB/Swiss-Prot
    Q5RL09, Q8C625, Q925K9
    Related
    ENSMUSP00000062783.6, ENSMUST00000050373.7
    Conserved Domains (1) summary
    cd14164
    Location:11267
    STKc_TSSK6-like; Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70354834..70356168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)