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RASSF4 Ras association domain family member 4 [ Homo sapiens (human) ]

Gene ID: 83937, updated on 11-Sep-2019

Summary

Official Symbol
RASSF4provided by HGNC
Official Full Name
Ras association domain family member 4provided by HGNC
Primary source
HGNC:HGNC:20793
See related
Ensembl:ENSG00000107551 MIM:610559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD037
Summary
The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 36.2), fat (RPKM 31.7) and 25 other tissues See more
Orthologs

Genomic context

See RASSF4 in Genome Data Viewer
Location:
10q11.21
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (44959753..44995891)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (45455183..45491337)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene TMEM72 antisense RNA 1 Neighboring gene eukaryotic translation initiation factor 2A pseudogene 4 Neighboring gene transmembrane protein 72 Neighboring gene Sharpr-MPRA regulatory region 2327 Neighboring gene uncharacterized LOC105378281 Neighboring gene Sharpr-MPRA regulatory region 8316 Neighboring gene DEPP1 autophagy regulator Neighboring gene ZNF22 antisense RNA 1 Neighboring gene zinc finger protein 22 Neighboring gene double homeobox A pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Hippo signaling pathway -multiple species, organism-specific biosystem (from KEGG)
    Hippo signaling pathway -multiple species, organism-specific biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • Hippo signaling pathway -multiple species, conserved biosystem (from KEGG)
    Hippo signaling pathway -multiple species, conserved biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC44914

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ras association domain-containing protein 4
Names
Ras association (RalGDS/AF-6) domain family 4
Ras association (RalGDS/AF-6) domain family member 4
Ras association domain family 4
tumor suppressor RASSF4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032023.4NP_114412.2  ras association domain-containing protein 4

    See identical proteins and their annotated locations for NP_114412.2

    Status: REVIEWED

    Source sequence(s)
    AL353801, BC032593, BI601296
    Consensus CDS
    CCDS7208.1
    UniProtKB/Swiss-Prot
    Q9H2L5
    Related
    ENSP00000339692.4, ENST00000340258.10
    Conserved Domains (1) summary
    cl00155
    Location:175261
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    44959753..44995891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540255.2XP_011538557.1  ras association domain-containing protein 4 isoform X7

    Conserved Domains (1) summary
    cl00155
    Location:39125
    UBQ; Ubiquitin-like proteins
  2. XM_017016757.2XP_016872246.1  ras association domain-containing protein 4 isoform X7

    Conserved Domains (1) summary
    cl00155
    Location:39125
    UBQ; Ubiquitin-like proteins
  3. XM_017016754.2XP_016872243.1  ras association domain-containing protein 4 isoform X1

    Conserved Domains (1) summary
    cl00155
    Location:248334
    UBQ; Ubiquitin-like proteins
  4. XM_017016755.2XP_016872244.1  ras association domain-containing protein 4 isoform X2

    Conserved Domains (1) summary
    cl00155
    Location:233319
    UBQ; Ubiquitin-like proteins
  5. XM_006718014.4XP_006718077.1  ras association domain-containing protein 4 isoform X4

    See identical proteins and their annotated locations for XP_006718077.1

    Conserved Domains (1) summary
    cl00155
    Location:206292
    UBQ; Ubiquitin-like proteins
  6. XM_017016758.2XP_016872247.1  ras association domain-containing protein 4 isoform X7

    Conserved Domains (1) summary
    cl00155
    Location:39125
    UBQ; Ubiquitin-like proteins
  7. XM_017016756.1XP_016872245.1  ras association domain-containing protein 4 isoform X7

    Conserved Domains (1) summary
    cl00155
    Location:39125
    UBQ; Ubiquitin-like proteins
  8. XM_006718013.3XP_006718076.1  ras association domain-containing protein 4 isoform X3

    Conserved Domains (1) summary
    cl00155
    Location:217303
    UBQ; Ubiquitin-like proteins
  9. XM_005271833.4XP_005271890.1  ras association domain-containing protein 4 isoform X5

    See identical proteins and their annotated locations for XP_005271890.1

    Conserved Domains (1) summary
    cl00155
    Location:202288
    UBQ; Ubiquitin-like proteins
  10. XM_005271835.4XP_005271892.1  ras association domain-containing protein 4 isoform X6

    Conserved Domains (1) summary
    cl00155
    Location:113199
    UBQ; Ubiquitin-like proteins

RNA

  1. XR_001747225.2 RNA Sequence

  2. XR_001747226.1 RNA Sequence

  3. XR_001747228.1 RNA Sequence

  4. XR_001747227.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178145.1: Suppressed sequence

    Description
    NM_178145.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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