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RASSF4 Ras association domain family member 4 [ Homo sapiens (human) ]

Gene ID: 83937, updated on 5-Aug-2022

Summary

Official Symbol
RASSF4provided by HGNC
Official Full Name
Ras association domain family member 4provided by HGNC
Primary source
HGNC:HGNC:20793
See related
Ensembl:ENSG00000107551 MIM:610559; AllianceGenome:HGNC:20793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD037
Summary
The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 36.2), fat (RPKM 31.7) and 25 other tissues See more
Orthologs
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Genomic context

See RASSF4 in Genome Data Viewer
Location:
10q11.21
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (44959802..44995891)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (45840766..45876855)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (45455250..45491339)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene TMEM72 antisense RNA 1 Neighboring gene transmembrane protein 72 Neighboring gene Sharpr-MPRA regulatory region 7362 Neighboring gene Sharpr-MPRA regulatory region 11970 Neighboring gene Sharpr-MPRA regulatory region 2327 Neighboring gene uncharacterized LOC105378281 Neighboring gene Sharpr-MPRA regulatory region 8316 Neighboring gene uncharacterized LOC124902530 Neighboring gene DEPP autophagy regulator 1 Neighboring gene ZNF22 antisense RNA 1 Neighboring gene zinc finger protein 22 Neighboring gene double homeobox A pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC44914

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras association domain-containing protein 4
Names
Ras association (RalGDS/AF-6) domain family 4
Ras association (RalGDS/AF-6) domain family member 4
Ras association domain family 4
tumor suppressor RASSF4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032023.4NP_114412.2  ras association domain-containing protein 4

    See identical proteins and their annotated locations for NP_114412.2

    Status: REVIEWED

    Source sequence(s)
    AL353801, BC032593, BI601296
    Consensus CDS
    CCDS7208.1
    UniProtKB/Swiss-Prot
    Q8TCK6, Q9H2L5
    Related
    ENSP00000339692.4, ENST00000340258.10
    Conserved Domains (1) summary
    cl00155
    Location:175261
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    44959802..44995891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    45840766..45876855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178145.1: Suppressed sequence

    Description
    NM_178145.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.