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KRTAP1-5 keratin associated protein 1-5 [ Homo sapiens (human) ]

Gene ID: 83895, updated on 8-Jul-2021

Summary

Official Symbol
KRTAP1-5provided by HGNC
Official Full Name
keratin associated protein 1-5provided by HGNC
Primary source
HGNC:HGNC:16777
See related
Ensembl:ENSG00000221852 MIM:608822
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAP1.5; KRTAP1.5
Summary
This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See KRTAP1-5 in Genome Data Viewer
Location:
17q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41026026..41027208, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39182278..39183460, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin associated protein 3-4, pseudogene Neighboring gene keratin associated protein 3-1 Neighboring gene keratin associated protein 1-4 Neighboring gene keratin associated protein 1-3

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126604

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin-associated protein 1-5
Names
high sulfur keratin-associated protein 1.5
keratin associated protein 1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031957.2NP_114163.1  keratin-associated protein 1-5

    See identical proteins and their annotated locations for NP_114163.1

    Status: REVIEWED

    Source sequence(s)
    AC007455, AJ406928
    Consensus CDS
    CCDS42321.1
    UniProtKB/Swiss-Prot
    Q9BYS1
    Related
    ENSP00000355302.5, ENST00000361883.6
    Conserved Domains (2) summary
    pfam01500
    Location:1170
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam13885
    Location:2487
    Keratin_B2_2; Keratin, high sulfur B2 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41026026..41027208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003871091.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    175421..176603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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