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OR1E2 olfactory receptor family 1 subfamily E member 2 [ Homo sapiens (human) ]

Gene ID: 8388, updated on 22-Sep-2022

Summary

Official Symbol
OR1E2provided by HGNC
Official Full Name
olfactory receptor family 1 subfamily E member 2provided by HGNC
Primary source
HGNC:HGNC:8190
See related
Ensembl:ENSG00000127780 AllianceGenome:HGNC:8190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR1E4; OR1E7; OST529; OR17-93; OR17-135; OR17-136
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR1E2 in Genome Data Viewer
Location:
17p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3432870..3433841, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3321795..3322756, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3336164..3337135, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 1 subfamily E member 1 Neighboring gene olfactory receptor family 3 subfamily A member 3 Neighboring gene spermatogenesis associated 22 Neighboring gene aspartoacylase Neighboring gene transient receptor potential cation channel subfamily V member 3

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
olfactory receptor 1E2
Names
olfactory receptor 17-93/17-135/17-136
olfactory receptor 1E4
olfactory receptor OR17-17
olfactory receptor OR17-3
olfactory receptor, family 1, subfamily E, member 4
olfactory receptor, family 1, subfamily E, member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003554.2NP_003545.1  olfactory receptor 1E2

    See identical proteins and their annotated locations for NP_003545.1

    Status: VALIDATED

    Source sequence(s)
    BC121106
    Consensus CDS
    CCDS11026.1
    UniProtKB/Swiss-Prot
    P47887, Q9UL13
    UniProtKB/TrEMBL
    A0A126GW81
    Related
    ENSP00000248384.1, ENST00000248384.1
    Conserved Domains (2) summary
    pfam00001
    Location:41298
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:31317
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    3432870..3433841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    3321795..3322756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)