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GPR61 G protein-coupled receptor 61 [ Homo sapiens (human) ]

Gene ID: 83873, updated on 23-Nov-2021

Summary

Official Symbol
GPR61provided by HGNC
Official Full Name
G protein-coupled receptor 61provided by HGNC
Primary source
HGNC:HGNC:13300
See related
Ensembl:ENSG00000156097 MIM:606916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BALGR; GPCR3
Summary
This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 1.2), thyroid (RPKM 0.5) and 3 other tissues See more
Orthologs
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Genomic context

See GPR61 in Genome Data Viewer
Location:
1p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (109539872..109547260)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110082494..110088470)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene adhesion molecule with Ig like domain 1 Neighboring gene uncharacterized LOC105378893 Neighboring gene G protein subunit alpha i3 Neighboring gene RNA, U6 small nuclear variant sequence with SNRPE pseudogene sequence Neighboring gene microRNA 197

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arrestin family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G-protein coupled receptor 61
Names
biogenic amine receptor-like G-protein coupled receptor
biogenic amine receptor-like GPCR
probable G-protein coupled receptor 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032758.2 RefSeqGene

    Range
    5001..12389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393907.1NP_001380836.1  G-protein coupled receptor 61

    Status: REVIEWED

    Source sequence(s)
    AL355145, AL355310
    Conserved Domains (1) summary
    cd15220
    Location:44352
    7tmA_GPR61_GPR62-like; G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_031936.6NP_114142.3  G-protein coupled receptor 61

    See identical proteins and their annotated locations for NP_114142.3

    Status: REVIEWED

    Source sequence(s)
    AF258342, AL355310, DA176879
    Consensus CDS
    CCDS801.1
    UniProtKB/Swiss-Prot
    Q9BZJ8
    UniProtKB/TrEMBL
    G4XH66
    Related
    ENSP00000385422.2, ENST00000404129.6
    Conserved Domains (1) summary
    cd15220
    Location:44352
    7tmA_GPR61_GPR62-like; G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    109539872..109547260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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