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ANGPTL6 angiopoietin like 6 [ Homo sapiens (human) ]

Gene ID: 83854, updated on 3-Oct-2020

Summary

Official Symbol
ANGPTL6provided by HGNC
Official Full Name
angiopoietin like 6provided by HGNC
Primary source
HGNC:HGNC:23140
See related
Ensembl:ENSG00000130812 MIM:609336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGF; ARP5
Expression
Ubiquitous expression in liver (RPKM 8.2), spleen (RPKM 5.1) and 25 other tissues See more
Orthologs

Genomic context

See ANGPTL6 in Genome Data Viewer
Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10092337..10106407, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10203013..10215710, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene microRNA 5589 Neighboring gene complement component 3 precursor pseudogene Neighboring gene shiftless antiviral inhibitor of ribosomal frameshifting Neighboring gene PPAN-P2RY11 readthrough Neighboring gene small nucleolar RNA, C/D box 105 Neighboring gene small nucleolar RNA, C/D box 105B Neighboring gene peter pan homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
GeneReviews: Not available
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
angiopoietin-related protein 6
Names
angiopoietin-like protein 6
angiopoietin-related growth factor
angiopoietin-related protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321411.2NP_001308340.1  angiopoietin-related protein 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC020931
    Consensus CDS
    CCDS12224.1
    UniProtKB/Swiss-Prot
    Q8NI99
    UniProtKB/TrEMBL
    A0A024R7A9
    Related
    ENSP00000467930.1, ENST00000592641.5
    Conserved Domains (1) summary
    cd00087
    Location:255468
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. NM_001387347.1NP_001374276.1  angiopoietin-related protein 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC020931
  3. NM_001387348.1NP_001374277.1  angiopoietin-related protein 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC020931
  4. NM_031917.3NP_114123.2  angiopoietin-related protein 6 precursor

    See identical proteins and their annotated locations for NP_114123.2

    Status: VALIDATED

    Source sequence(s)
    AC020931
    Consensus CDS
    CCDS12224.1
    UniProtKB/Swiss-Prot
    Q8NI99
    UniProtKB/TrEMBL
    A0A024R7A9
    Related
    ENSP00000253109.3, ENST00000253109.4
    Conserved Domains (1) summary
    cd00087
    Location:255468
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    10092337..10106407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528347.3XP_011526649.1  angiopoietin-related protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q8NI99
    UniProtKB/TrEMBL
    A0A024R7A9
    Conserved Domains (1) summary
    cd00087
    Location:255468
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. XM_011528350.3XP_011526652.1  angiopoietin-related protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q8NI99
    UniProtKB/TrEMBL
    A0A024R7A9
    Conserved Domains (1) summary
    cd00087
    Location:255468
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  3. XM_017027347.2XP_016882836.1  angiopoietin-related protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q8NI99
    UniProtKB/TrEMBL
    A0A024R7A9
    Conserved Domains (1) summary
    cd00087
    Location:255468
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  4. XM_011528349.3XP_011526651.1  angiopoietin-related protein 6 isoform X3

    See identical proteins and their annotated locations for XP_011526651.1

    Conserved Domains (1) summary
    cd00087
    Location:322535
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  5. XM_011528348.3XP_011526650.1  angiopoietin-related protein 6 isoform X3

    See identical proteins and their annotated locations for XP_011526650.1

    Conserved Domains (1) summary
    cd00087
    Location:322535
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RNA

  1. XR_002958369.1 RNA Sequence

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