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ROPN1L rhophilin associated tail protein 1 like [ Homo sapiens (human) ]

Gene ID: 83853, updated on 17-Jun-2019

Summary

Official Symbol
ROPN1Lprovided by HGNC
Official Full Name
rhophilin associated tail protein 1 likeprovided by HGNC
Primary source
HGNC:HGNC:24060
See related
Ensembl:ENSG00000145491 MIM:611756
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASP; RSPH11
Summary
This gene encodes a member of the ropporin family. The encoded protein is present in sperm and interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2014]
Expression
Restricted expression toward testis (RPKM 83.7) See more
Orthologs

Genomic context

See ROPN1L in Genome Data Viewer
Location:
5p15.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (10441879..10482807)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (10441974..10465138)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 6 Neighboring gene microRNA 10397 Neighboring gene ROPN1L antisense RNA 1 Neighboring gene uncharacterized LOC105369214 Neighboring gene Sharpr-MPRA regulatory regions 9329 and 12995 Neighboring gene microRNA 6131 Neighboring gene ribosomal protein L30 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies.
NHGRI GWA Catalog
Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23003, FLJ25776

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
epithelial cilium movement IC
Inferred by Curator
more info
PubMed 
flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
sperm capacitation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cilium IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
motile cilium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ropporin-1-like protein
Names
AKAP-associated sperm protein
ROPN1-like protein
radial spoke head 11 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201466.2NP_001188395.1  ropporin-1-like protein

    See identical proteins and their annotated locations for NP_001188395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR and encodes the same protein, as compared to variant 1.
    Source sequence(s)
    AF239723, BX113042, CV024170, DB479784
    Consensus CDS
    CCDS3879.1
    UniProtKB/Swiss-Prot
    Q96C74
    Related
    ENSP00000421405.1, ENST00000503804.5
    Conserved Domains (1) summary
    cl02594
    Location:1551
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
  2. NM_031916.5NP_114122.2  ropporin-1-like protein

    See identical proteins and their annotated locations for NP_114122.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AC092336, AK098642, BC014607
    Consensus CDS
    CCDS3879.1
    UniProtKB/Swiss-Prot
    Q96C74
    Related
    ENSP00000274134.4, ENST00000274134.5
    Conserved Domains (1) summary
    cl02594
    Location:1551
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    10441879..10482807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009947.2XP_016865436.1  ropporin-1-like protein isoform X3

  2. XM_006714504.3XP_006714567.1  ropporin-1-like protein isoform X1

    See identical proteins and their annotated locations for XP_006714567.1

    Conserved Domains (1) summary
    cl02594
    Location:1551
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
  3. XM_017009946.2XP_016865435.1  ropporin-1-like protein isoform X2

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