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ARMC10 armadillo repeat containing 10 [ Homo sapiens (human) ]

Gene ID: 83787, updated on 9-Feb-2020

Summary

Official Symbol
ARMC10provided by HGNC
Official Full Name
armadillo repeat containing 10provided by HGNC
Primary source
HGNC:HGNC:21706
See related
Ensembl:ENSG00000170632 MIM:611864
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SVH; PNAS112; PNAS-112; PSEC0198
Summary
This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in thyroid (RPKM 11.8), adrenal (RPKM 9.8) and 25 other tissues See more
Orthologs

Genomic context

See ARMC10 in Genome Data Viewer
Location:
7q22.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (103074881..103099773)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102715174..102740210)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 13 Neighboring gene Sharpr-MPRA regulatory region 11249 Neighboring gene nuclear factor, erythroid 4 Neighboring gene crystallin zeta pseudogene 1 Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene uncharacterized LOC105375434 Neighboring gene ribosomal protein L19 pseudogene 12 Neighboring gene ribosomal protein L23a pseudogene 95

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3195, FLJ37850

Gene Ontology Provided by GOA

Process Evidence Code Pubs
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
armadillo repeat-containing protein 10
Names
specific splicing variant involved in hepatocarcinogenesis
splicing variant involved in hepatocarcinogenesis protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030014.1 RefSeqGene

    Range
    5260..29879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001161009.3NP_001154481.1  armadillo repeat-containing protein 10 isoform b

    See identical proteins and their annotated locations for NP_001154481.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) lacks an in-frame exon in the 5' coding region compared to variant A. This results in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AI761577, AY150851, AY150853, BM989172, BQ004061, BQ440425, BU941174
    Consensus CDS
    CCDS55146.1
    UniProtKB/Swiss-Prot
    Q8N2F6
    Related
    ENSP00000413619.2, ENST00000441711.6
    Conserved Domains (3) summary
    cd00020
    Location:55140
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:52302
    Arm_2; Armadillo-like
    sd00043
    Location:5684
    ARM; armadillo repeat [structural motif]
  2. NM_001161010.3NP_001154482.1  armadillo repeat-containing protein 10 isoform c

    See identical proteins and their annotated locations for NP_001154482.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) lacks an in-frame exon in the 3' coding region compared to variant A. This results in a shorter protein (isoform c) compared to isoform a.
    Source sequence(s)
    AI761577, AY150851, AY150852, BM989172, BQ004061, BQ440425, BU941174
    Consensus CDS
    CCDS55145.1
    UniProtKB/Swiss-Prot
    Q8N2F6
    Related
    ENSP00000396654.2, ENST00000428183.6
    Conserved Domains (3) summary
    cd00020
    Location:90186
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:87278
    Arm_2; Armadillo-like
    sd00043
    Location:91119
    ARM; armadillo repeat [structural motif]
  3. NM_001161011.2NP_001154483.1  armadillo repeat-containing protein 10 isoform e

    See identical proteins and their annotated locations for NP_001154483.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (E) lacks two in-frame exons in the coding region compared to variant A. This results in a shorter protein (isoform e) compared to isoform a.
    Source sequence(s)
    AI761577, AK301565, AY150851, BM989172, BQ004061, BQ440425, BU941174
    Consensus CDS
    CCDS55147.1
    UniProtKB/Swiss-Prot
    Q8N2F6
    Related
    ENSP00000397969.1, ENST00000425331.5
    Conserved Domains (3) summary
    cd00020
    Location:55140
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:52278
    Arm_2; Armadillo-like
    sd00043
    Location:5684
    ARM; armadillo repeat [structural motif]
  4. NM_001161012.3NP_001154484.1  armadillo repeat-containing protein 10 isoform d

    See identical proteins and their annotated locations for NP_001154484.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) lacks two in-frame exons in the coding region compared to variant A. This results in a shorter protein (isoform d) compared to isoform a.
    Source sequence(s)
    AI761577, AY150851, BM989172, BQ004061, BQ440425, BU941174
    Consensus CDS
    CCDS55148.1
    UniProtKB/Swiss-Prot
    Q8N2F6
    Related
    ENSP00000405612.1, ENST00000454559.5
    Conserved Domains (3) summary
    cd00020
    Location:55151
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:52243
    Arm_2; Armadillo-like
    sd00043
    Location:5684
    ARM; armadillo repeat [structural motif]
  5. NM_001161013.2NP_001154485.1  armadillo repeat-containing protein 10 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (F) lacks three in-frame exons in the coding region compared to variant A. This results in a shorter protein (isoform f) compared to isoform a.
    Source sequence(s)
    AF275808, AI761577, AY150851, BM989172, BQ004061, BQ440425, BU941174
    Consensus CDS
    CCDS55149.1
    UniProtKB/Swiss-Prot
    Q8N2F6
    Related
    ENSP00000440463.1, ENST00000541300.5
    Conserved Domains (3) summary
    cd00020
    Location:55169
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:52219
    Arm_2; Armadillo-like
    sd00043
    Location:5684
    ARM; armadillo repeat [structural motif]
  6. NM_031905.5NP_114111.2  armadillo repeat-containing protein 10 isoform a

    See identical proteins and their annotated locations for NP_114111.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AI761577, AY150851, AY150854, BM989172, BQ004061, BQ440425, BU941174
    Consensus CDS
    CCDS5728.1
    UniProtKB/Swiss-Prot
    Q8N2F6
    Related
    ENSP00000319412.3, ENST00000323716.8
    Conserved Domains (3) summary
    cd00020
    Location:90175
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:87337
    Arm_2; Armadillo-like
    sd00043
    Location:91119
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    103074881..103099773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012685.2XP_016868174.1  armadillo repeat-containing protein 10 isoform X2

  2. XM_011516601.3XP_011514903.1  armadillo repeat-containing protein 10 isoform X3

    Conserved Domains (3) summary
    cd00020
    Location:63148
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:60310
    Arm_2; Armadillo-like
    sd00043
    Location:6492
    ARM; armadillo repeat [structural motif]
  3. XM_017012684.2XP_016868173.1  armadillo repeat-containing protein 10 isoform X1

    Conserved Domains (3) summary
    cd00020
    Location:99184
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:96346
    Arm_2; Armadillo-like
    sd00043
    Location:100128
    ARM; armadillo repeat [structural motif]
  4. XM_017012686.2XP_016868175.1  armadillo repeat-containing protein 10 isoform X4

  5. XM_017012688.2XP_016868177.1  armadillo repeat-containing protein 10 isoform X7

  6. XM_005250628.3XP_005250685.1  armadillo repeat-containing protein 10 isoform X8

    UniProtKB/TrEMBL
    H7BXQ8
    Related
    ENSP00000319798.6, ENST00000323735.10
    Conserved Domains (2) summary
    cd00020
    Location:90175
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:91119
    ARM; armadillo repeat [structural motif]
  7. XM_017012689.2XP_016868178.1  armadillo repeat-containing protein 10 isoform X9

  8. XM_011516602.2XP_011514904.1  armadillo repeat-containing protein 10 isoform X5

    Conserved Domains (3) summary
    cd00020
    Location:27112
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04826
    Location:24274
    Arm_2; Armadillo-like
    sd00043
    Location:2856
    ARM; armadillo repeat [structural motif]
  9. XM_017012687.1XP_016868176.1  armadillo repeat-containing protein 10 isoform X6

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187559.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    144966..158099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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