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HYAL3 hyaluronidase 3 [ Homo sapiens (human) ]

Gene ID: 8372, updated on 12-Aug-2018

Summary

Official Symbol
HYAL3provided by HGNC
Official Full Name
hyaluronidase 3provided by HGNC
Primary source
HGNC:HGNC:5322
See related
Ensembl:ENSG00000186792 MIM:604038; Vega:OTTHUMG00000156936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LUCA3; HYAL-3; LUCA-3
Summary
This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]
Expression
Broad expression in bone marrow (RPKM 11.6), testis (RPKM 6.6) and 20 other tissues See more
Orthologs

Genomic context

See HYAL3 in Genome Data Viewer
Location:
3p21.31
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (50292828..50299468, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50330259..50336899, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene semaphorin 3B Neighboring gene microRNA 6872 Neighboring gene leucine rich single-pass membrane protein 2 Neighboring gene interferon related developmental regulator 2 Neighboring gene N(alpha)-acetyltransferase 80, NatH catalytic subunit Neighboring gene hyaluronidase 1 Neighboring gene hyaluronidase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hyaluronoglucuronidase activity IDA
Inferred from Direct Assay
more info
PubMed 
hyalurononglucosaminidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
cartilage development IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to UV-B IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-1 IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
hyaluronan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ovarian follicle development ISS
Inferred from Sequence or Structural Similarity
more info
 
ovarian follicle atresia ISS
Inferred from Sequence or Structural Similarity
more info
 
penetration of zona pellucida ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of acrosomal vesicle exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acrosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
sperm midpiece ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
hyaluronidase-3
Names
hyaluronoglucosaminidase 3
lung carcinoma protein 3
NP_001186958.1
NP_001186959.1
NP_001186960.1
NP_001186961.1
NP_003540.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001200029.1NP_001186958.1  hyaluronidase-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001186958.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Both variants 1 and 5 encode the same protein (isoform 1).
    Source sequence(s)
    BC012892, DB269188, DB319349, U90094
    Consensus CDS
    CCDS2815.1
    UniProtKB/Swiss-Prot
    O43820
    UniProtKB/TrEMBL
    A0A024R2Y7
    Related
    ENSP00000479935.1, OTTHUMP00000281512, ENST00000621157.5, OTTHUMT00000488539
    Conserved Domains (1) summary
    pfam01630
    Location:24349
    Glyco_hydro_56; Hyaluronidase
  2. NM_001200030.1NP_001186959.1  hyaluronidase-3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001186959.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as HYAL3-v1, lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF036035, AF502909, DB319349
    Consensus CDS
    CCDS56257.1
    UniProtKB/Swiss-Prot
    O43820
    Related
    ENSP00000391922.1, OTTHUMP00000281511, ENST00000450982.6, OTTHUMT00000488534
    Conserved Domains (1) summary
    pfam01630
    Location:24319
    Glyco_hydro_56; Hyaluronidase
  3. NM_001200031.1NP_001186960.1  hyaluronidase-3 isoform 3

    See identical proteins and their annotated locations for NP_001186960.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as HYAL3-v2, initiates translation at an upstream start codon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF036035, AF502910, DB319349
    Consensus CDS
    CCDS56260.1
    UniProtKB/Swiss-Prot
    O43820
    Related
    ENSP00000401092.1, OTTHUMP00000211054, ENST00000415204.5, OTTHUMT00000346666
    Conserved Domains (1) summary
    pfam01630
    Location:3100
    Glyco_hydro_56; Hyaluronidase
  4. NM_001200032.1NP_001186961.1  hyaluronidase-3 isoform 4

    See identical proteins and their annotated locations for NP_001186961.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as HYAL3-v3, initiates translation at an upstream start codon and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF036035, AF502911, DB319349
    Consensus CDS
    CCDS56259.1
    UniProtKB/Swiss-Prot
    O43820
    Related
    ENSP00000424633.1, OTTHUMP00000219781, ENST00000513170.1, OTTHUMT00000363925
    Conserved Domains (1) summary
    pfam01630
    Location:370
    Glyco_hydro_56; Hyaluronidase
  5. NM_003549.3NP_003540.2  hyaluronidase-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003540.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as HYAL3-wt, represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 5 encode the same protein.
    Source sequence(s)
    AF036035, DB319349
    Consensus CDS
    CCDS2815.1
    UniProtKB/Swiss-Prot
    O43820
    UniProtKB/TrEMBL
    A0A024R2Y7
    Related
    ENSP00000337425.1, OTTHUMP00000211052, ENST00000336307.5, OTTHUMT00000346664
    Conserved Domains (1) summary
    pfam01630
    Location:24349
    Glyco_hydro_56; Hyaluronidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    50292828..50299468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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