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HYAL3 hyaluronidase 3 [ Homo sapiens (human) ]

Gene ID: 8372, updated on 8-Jul-2021

Summary

Official Symbol
HYAL3provided by HGNC
Official Full Name
hyaluronidase 3provided by HGNC
Primary source
HGNC:HGNC:5322
See related
Ensembl:ENSG00000186792 MIM:604038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LUCA3; HYAL-3; LUCA-3
Summary
This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]
Expression
Broad expression in bone marrow (RPKM 11.6), testis (RPKM 6.6) and 20 other tissues See more
Orthologs
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Genomic context

See HYAL3 in Genome Data Viewer
Location:
3p21.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (50292832..50299405, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50330263..50336836, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene semaphorin 3B Neighboring gene microRNA 6872 Neighboring gene leucine rich single-pass membrane protein 2 Neighboring gene interferon related developmental regulator 2 Neighboring gene N-alpha-acetyltransferase 80, NatH catalytic subunit Neighboring gene hyaluronidase 1 Neighboring gene hyaluronidase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hyaluronoglucuronidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hyalurononglucosaminidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cartilage development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to UV-B IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to interleukin-1 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in hyaluronan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hyaluronan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ovarian follicle development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ovarian follicle atresia ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in penetration of zona pellucida ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of acrosomal vesicle exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to virus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in sperm midpiece ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
hyaluronidase-3
Names
hyaluronoglucosaminidase 3
lung carcinoma protein 3
NP_001186958.1
NP_001186959.1
NP_001186960.1
NP_001186961.1
NP_003540.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001200029.2NP_001186958.1  hyaluronidase-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001186958.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Both variants 1 and 5 encode the same protein (isoform 1).
    Source sequence(s)
    BC012892, DB269188, U90094
    Consensus CDS
    CCDS2815.1
    UniProtKB/Swiss-Prot
    O43820
    UniProtKB/TrEMBL
    A0A024R2Y7
    Related
    ENSP00000479935.1, ENST00000621157.5
    Conserved Domains (1) summary
    pfam01630
    Location:24349
    Glyco_hydro_56; Hyaluronidase
  2. NM_001200030.2NP_001186959.1  hyaluronidase-3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001186959.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as HYAL3-v1, lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF036035, AF502909, DB319349
    Consensus CDS
    CCDS56257.1
    UniProtKB/Swiss-Prot
    O43820
    Related
    ENSP00000391922.1, ENST00000450982.6
    Conserved Domains (1) summary
    pfam01630
    Location:24319
    Glyco_hydro_56; Hyaluronidase
  3. NM_001200031.2NP_001186960.1  hyaluronidase-3 isoform 3

    See identical proteins and their annotated locations for NP_001186960.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as HYAL3-v2, initiates translation at an upstream start codon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF036035, AF502910, DB319349
    Consensus CDS
    CCDS56260.1
    UniProtKB/Swiss-Prot
    O43820
    Related
    ENSP00000401092.1, ENST00000415204.5
    Conserved Domains (1) summary
    pfam01630
    Location:3100
    Glyco_hydro_56; Hyaluronidase
  4. NM_001200032.2NP_001186961.1  hyaluronidase-3 isoform 4

    See identical proteins and their annotated locations for NP_001186961.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as HYAL3-v3, initiates translation at an upstream start codon and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF036035, AF502911, DB319349
    Consensus CDS
    CCDS56259.1
    UniProtKB/Swiss-Prot
    O43820
    Related
    ENSP00000424633.1, ENST00000513170.1
    Conserved Domains (1) summary
    pfam01630
    Location:370
    Glyco_hydro_56; Hyaluronidase
  5. NM_003549.4NP_003540.2  hyaluronidase-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003540.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as HYAL3-wt, represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 5 encode the same protein.
    Source sequence(s)
    AF036035
    Consensus CDS
    CCDS2815.1
    UniProtKB/Swiss-Prot
    O43820
    UniProtKB/TrEMBL
    A0A024R2Y7
    Related
    ENSP00000337425.1, ENST00000336307.6
    Conserved Domains (1) summary
    pfam01630
    Location:24349
    Glyco_hydro_56; Hyaluronidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    50292832..50299405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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