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Akr1c6 aldo-keto reductase family 1, member C6 [ Mus musculus (house mouse) ]

Gene ID: 83702, updated on 2-Nov-2024

Summary

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Official Symbol
Akr1c6provided by MGI
Official Full Name
aldo-keto reductase family 1, member C6provided by MGI
Primary source
MGI:MGI:1933427
See related
Ensembl:ENSMUSG00000021210 AllianceGenome:MGI:1933427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Akr1c1; Hsd17b5; 3alpha-HSD
Summary
Enables aldo-keto reductase (NADPH) activity and estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Involved in steroid biosynthetic process. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and steroid metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; liver and biliary system; lung; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward liver adult (RPKM 103.4) See more
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Genomic context

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See Akr1c6 in Genome Data Viewer
Location:
13 A1; 13 2.48 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (4484354..4507529)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (4434311..4457530)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C12 Neighboring gene STARR-seq mESC enhancer starr_33505 Neighboring gene STARR-seq mESC enhancer starr_33506 Neighboring gene STARR-seq mESC enhancer starr_33507 Neighboring gene predicted gene 9973 Neighboring gene STARR-seq mESC enhancer starr_33508 Neighboring gene STARR-seq mESC enhancer starr_33510 Neighboring gene aldo-keto reductase family 1, member C20 Neighboring gene STARR-seq mESC enhancer starr_33513 Neighboring gene predicted gene, 40657

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1). Rheault P, et al. Biochim Biophys Acta, 1999 Oct 6. PMID 10500239
  2. Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship. Rheault P, et al. Cytogenet Cell Genet, 1999. PMID 10393440
  3. Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney. Imamura Y, et al. J Steroid Biochem Mol Biol, 2007 Oct. PMID 17629694
  4. Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family. Deyashiki Y, et al. J Biol Chem, 1995 May 5. PMID 7737980
  5. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Agís-Balboa RC, et al. Proc Natl Acad Sci U S A, 2006 Sep 26. PMID 16984997, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A catalysis-independent role for AKR1C3 on AR activity via Siah2 has been identified.
    Title: The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.
  2. 17beta-HSD 5 gene is up-regulated in both male and female developing lungs of the fetal mouse.
    Title: 17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.
  3. This study evaluates 5alpha-R type I and 3alpha-HSD mRNA expression level in mouse brain by using in situ hybridization.
    Title: Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables Delta4-3-oxosteroid 5beta-reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables aldo-keto reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldo-keto reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldose reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase (B-specific) activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables bile acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bile acid binding ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables chlordecone reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables geranylgeranyl reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables ketoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables ketosteroid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ketosteroid monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables testosterone 17-beta-dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables testosterone dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in daunorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in doxorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in progesterone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within steroid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
estradiol 17 beta-dehydrogenase 5
Names
17-beta-HSD 5
17HSD type 5
aldo-keto reductase family 1, member C1 (aldehyde reductase)
estradiol 17-beta-dehydrogenase (A-specific)
hydroxysteroid 17-beta dehydrogenase 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418783.1 → NP_001405712.1  estradiol 17 beta-dehydrogenase 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166056

  2. NM_001418784.1 → NP_001405713.1  estradiol 17 beta-dehydrogenase 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166056

  3. NM_030611.4 → NP_085114.1  estradiol 17 beta-dehydrogenase 5 isoform 1

    See identical proteins and their annotated locations for NP_085114.1

    Status: VALIDATED

    Source sequence(s)
    AC166056
    Consensus CDS
    CCDS26223.1
    UniProtKB/Swiss-Prot
    P70694
    UniProtKB/TrEMBL
    Q3UEM0
    Related
    ENSMUSP00000021630.9, ENSMUST00000021630.15
    Conserved Domains (2) summary
    COG0656
    Location:5 → 323
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16 → 298
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    4484354..4507529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70694.1 GenPept UniProtKB/Swiss-Prot:P70694

Gene LinkOut

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