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CRISPLD1 cysteine rich secretory protein LCCL domain containing 1 [ Homo sapiens (human) ]

Gene ID: 83690, updated on 1-Jun-2020

Summary

Official Symbol
CRISPLD1provided by HGNC
Official Full Name
cysteine rich secretory protein LCCL domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18206
See related
Ensembl:ENSG00000121005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRISP10; LCRISP1; CRISP-10
Expression
Broad expression in prostate (RPKM 14.1), thyroid (RPKM 6.1) and 15 other tissues See more
Orthologs

Genomic context

See CRISPLD1 in Genome Data Viewer
Location:
8q21.13
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (74984505..75034558)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (75896708..75946793)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene MIR2052 host gene Neighboring gene microRNA 2052 Neighboring gene peptidase inhibitor 15 Neighboring gene uncharacterized LOC105375905 Neighboring gene cancer susceptibility 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp762F133

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
face morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cysteine-rich secretory protein LCCL domain-containing 1
Names
CocoaCrisp
LCCL domain-containing cysteine-rich secretory protein 1
cysteine-rich secretory protein 10
trypsin inhibitor Hl

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286777.2NP_001273706.1  cysteine-rich secretory protein LCCL domain-containing 1 isoform 2

    See identical proteins and their annotated locations for NP_001273706.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) is shorter and has distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC100782, AC102801, AK304350
    Consensus CDS
    CCDS69497.1
    UniProtKB/Swiss-Prot
    Q9H336
    Related
    ENSP00000429746.1, ENST00000517786.1
    Conserved Domains (2) summary
    smart00603
    Location:105189
    LCCL; LCCL domain
    pfam03815
    Location:208306
    LCCL; LCCL domain
  2. NM_001286778.2NP_001273707.1  cysteine-rich secretory protein LCCL domain-containing 1 isoform 3

    See identical proteins and their annotated locations for NP_001273707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC100782, AK304034, DC414945
    Consensus CDS
    CCDS75754.1
    UniProtKB/TrEMBL
    B7Z8V9
    Related
    ENSP00000430105.1, ENST00000523524.5
    Conserved Domains (2) summary
    smart00603
    Location:103187
    LCCL; LCCL domain
    pfam03815
    Location:206304
    LCCL; LCCL domain
  3. NM_031461.6NP_113649.1  cysteine-rich secretory protein LCCL domain-containing 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_113649.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC100782, BC020514, BP357192, BU790187
    Consensus CDS
    CCDS6219.1
    UniProtKB/Swiss-Prot
    Q9H336
    Related
    ENSP00000262207.4, ENST00000262207.9
    Conserved Domains (2) summary
    smart00603
    Location:291375
    LCCL; LCCL domain
    cd05380
    Location:63207
    SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    74984505..75034558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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