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TEKT1 tektin 1 [ Homo sapiens (human) ]

Gene ID: 83659, updated on 10-Dec-2024

Summary

Official Symbol
TEKT1provided by HGNC
Official Full Name
tektin 1provided by HGNC
Primary source
HGNC:HGNC:15534
See related
Ensembl:ENSG00000167858 MIM:609002; AllianceGenome:HGNC:15534
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 17.1) See more
Orthologs
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Genomic context

See TEKT1 in Genome Data Viewer
Location:
17p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (6797993..6831729, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (6698681..6732423, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6701312..6735048, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903905 Neighboring gene XIAP associated factor 1 Neighboring gene F-box protein 39 Neighboring gene GATA motif-containing MPRA enhancer 34 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8079 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:6757097-6758296 Neighboring gene arachidonate 12-lipoxygenase pseudogene 2 Neighboring gene uncharacterized LOC124903907 Neighboring gene uncharacterized LOC124903908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6796999-6797500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6797501-6798000

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in axonemal microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus HDA PubMed 
is_active_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053285.2NP_444515.1  tektin-1

    See identical proteins and their annotated locations for NP_444515.1

    Status: REVIEWED

    Source sequence(s)
    AC034305, BC014599
    Consensus CDS
    CCDS11083.1
    UniProtKB/Swiss-Prot
    D3DTM7, Q969V4
    UniProtKB/TrEMBL
    A8K9V3
    Related
    ENSP00000341346.2, ENST00000338694.7
    Conserved Domains (1) summary
    pfam03148
    Location:16395
    Tektin; Tektin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    6797993..6831729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524027.4XP_011522329.1  tektin-1 isoform X1

    Conserved Domains (1) summary
    pfam03148
    Location:16286
    Tektin; Tektin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    6698681..6732423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317472.1XP_054173447.1  tektin-1 isoform X1