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TEX101 testis expressed 101 [ Homo sapiens (human) ]

Gene ID: 83639, updated on 25-Jan-2022

Summary

Official Symbol
TEX101provided by HGNC
Official Full Name
testis expressed 101provided by HGNC
Primary source
HGNC:HGNC:30722
See related
Ensembl:ENSG00000131126 MIM:612665; AllianceGenome:HGNC:30722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGRG; CT131; GTPR867; NYD-SP8; PRO1884; SPATA44; TES101RP
Summary
Predicted to be involved in binding activity of sperm to zona pellucida; flagellated sperm motility; and regulation of flagellated sperm motility. Predicted to be located in acrosomal vesicle; extracellular region; and plasma membrane. Predicted to be active in plasma membrane raft. Predicted to be anchored component of plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward testis (RPKM 41.7) See more
Orthologs
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Genomic context

See TEX101 in Genome Data Viewer
Location:
19q13.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43388611..43418613)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43892763..43922749)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CD177 molecule Neighboring gene CD177 molecule pseudogene 1 Neighboring gene RNA, 28S ribosomal pseudogene Neighboring gene LY6/PLAUR domain containing 3 Neighboring gene pleckstrin homology like domain family B member 3 Neighboring gene Sharpr-MPRA regulatory region 2471

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4766

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in binding of sperm to zona pellucida ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in anchored component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in anchored component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in plasma membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
testis-expressed protein 101
Names
TES101-reactive protein
cancer/testis antigen 131
cell surface receptor NYD-SP8
scleroderma-associated autoantigen
spermatogenesis associated 44
spermatogenesis-related gene protein
testis expressed sequence 101
testis-expressed sequence 101 protein
testis-specific protein TES101RP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130011.3NP_001123483.1  testis-expressed protein 101 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001123483.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 5' end and uses a downstream translation start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when compared to isoform 1.
    Source sequence(s)
    AC018758, AY359077
    Consensus CDS
    CCDS59393.1
    UniProtKB/Swiss-Prot
    Q9BY14
    Related
    ENSP00000472769.1, ENST00000598265.2
    Conserved Domains (1) summary
    cl10471
    Location:140209
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  2. NM_031451.5NP_113639.4  testis-expressed protein 101 isoform 1

    See identical proteins and their annotated locations for NP_113639.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AA417291, AF241268, BC001861
    Consensus CDS
    CCDS12619.1
    UniProtKB/Swiss-Prot
    Q9BY14
    UniProtKB/TrEMBL
    A0A024R0T7
    Related
    ENSP00000472308.1, ENST00000602198.5
    Conserved Domains (1) summary
    cl10471
    Location:158227
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43388611..43418613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259303.3XP_005259360.2  testis-expressed protein 101 isoform X1

    Related
    ENST00000601707.1
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