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Tktl1 transketolase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 83553, updated on 8-Feb-2024

Summary

Official Symbol
Tktl1provided by MGI
Official Full Name
transketolase-like 1provided by MGI
Primary source
MGI:MGI:1933244
See related
Ensembl:ENSMUSG00000031397 AllianceGenome:MGI:1933244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be located in cytosol. Is expressed in early conceptus and secondary oocyte. Orthologous to human TKTL1 (transketolase like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.7) and CNS E18 (RPKM 0.1) See more
Orthologs
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Genomic context

See Tktl1 in Genome Data Viewer
Location:
X A7.3; X 37.83 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73220865..73252104)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74177259..74208498)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene testis expressed 28 Neighboring gene ribosomal protein L3, pseudogene 2 Neighboring gene filamin, alpha Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:71489308-71489552 Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene emerin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC132800

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables thiamine pyrophosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transketolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transketolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transketolase-like protein 1
Names
TK 2
transketolase 2
NP_113556.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031379.2NP_113556.2  transketolase-like protein 1

    See identical proteins and their annotated locations for NP_113556.2

    Status: VALIDATED

    Source sequence(s)
    AF285571, AK029546, BX512243
    Consensus CDS
    CCDS30221.1
    UniProtKB/Swiss-Prot
    B1AYP0, Q684Q5, Q8CDU7, Q99MX0
    Related
    ENSMUSP00000010127.6, ENSMUST00000010127.12
    Conserved Domains (4) summary
    cd07033
    Location:293446
    TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
    PRK05899
    Location:17590
    PRK05899; transketolase; Reviewed
    pfam02780
    Location:463585
    Transketolase_C; Transketolase, C-terminal domain
    cl01629
    Location:29238
    TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    73220865..73252104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)