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FAM110A family with sequence similarity 110 member A [ Homo sapiens (human) ]

Gene ID: 83541, updated on 5-Aug-2022

Summary

Official Symbol
FAM110Aprovided by HGNC
Official Full Name
family with sequence similarity 110 member Aprovided by HGNC
Primary source
HGNC:HGNC:16188
See related
Ensembl:ENSG00000125898 MIM:611393; AllianceGenome:HGNC:16188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
F10; C20orf55; bA371L19.3
Summary
Predicted to be located in cytoplasm; microtubule organizing center; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in skin (RPKM 6.2), spleen (RPKM 5.8) and 23 other tissues See more
Orthologs
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Genomic context

See FAM110A in Genome Data Viewer
Location:
20p13
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (833715..846277)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (880828..893378)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (814358..826920)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 52 member 3 Neighboring gene CRISPRi-validated cis-regulatory element chr20.80 Neighboring gene ribosomal protein S10 pseudogene 5 Neighboring gene uncharacterized LOC124904854 Neighboring gene angiopoietin 4 Neighboring gene uncharacterized LOC105372492

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2450, MGC4675

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042353.3NP_001035812.1  protein FAM110A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 encode the same protein.
    Source sequence(s)
    AL118502, BC004222, BI911808, DA915382
    Consensus CDS
    CCDS13008.1
    UniProtKB/Swiss-Prot
    Q5R1M7, Q9BQ89
    Related
    ENSP00000371367.3, ENST00000381941.8
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus
  2. NM_001289145.2NP_001276074.1  protein FAM110A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 encode the same protein.
    Source sequence(s)
    AL118502, BC004222, BI909768, HY035293
    Consensus CDS
    CCDS13008.1
    UniProtKB/Swiss-Prot
    Q5R1M7, Q9BQ89
    Related
    ENSP00000354163.2, ENST00000304189.6
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus
  3. NM_001289146.2NP_001276075.1  protein FAM110A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 encode the same protein.
    Source sequence(s)
    AL118502, BI909945, HY035293
    Consensus CDS
    CCDS13008.1
    UniProtKB/Swiss-Prot
    Q5R1M7, Q9BQ89
    Related
    ENSP00000371365.1, ENST00000381939.1
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus
  4. NM_001289147.2NP_001276076.1  protein FAM110A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 encode the same protein.
    Source sequence(s)
    AL118502, BC004222, CN425669, CX753944
    Consensus CDS
    CCDS13008.1
    UniProtKB/Swiss-Prot
    Q5R1M7, Q9BQ89
    Related
    ENSP00000445228.1, ENST00000541082.2
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus
  5. NM_031424.6NP_113612.1  protein FAM110A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the same protein as variants 2, 3, 4, 5, and 6.
    Source sequence(s)
    AL118502, AL530841, BC004222
    Consensus CDS
    CCDS13008.1
    UniProtKB/Swiss-Prot
    Q5R1M7, Q9BQ89
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus
  6. NM_207121.5NP_997004.1  protein FAM110A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 encode the same protein.
    Source sequence(s)
    AL118502, BC004222
    Consensus CDS
    CCDS13008.1
    UniProtKB/Swiss-Prot
    Q5R1M7, Q9BQ89
    Related
    ENSP00000246100.3, ENST00000246100.3
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    833715..846277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440531.1XP_047296487.1  protein FAM110A isoform X1

    UniProtKB/Swiss-Prot
    Q5R1M7
  2. XM_011529381.3XP_011527683.1  protein FAM110A isoform X1

    UniProtKB/Swiss-Prot
    Q5R1M7, Q9BQ89
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    880828..893378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)