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FAM110A family with sequence similarity 110 member A [ Homo sapiens (human) ]

Gene ID: 83541, updated on 21-Dec-2019

Summary

Official Symbol
FAM110Aprovided by HGNC
Official Full Name
family with sequence similarity 110 member Aprovided by HGNC
Primary source
HGNC:HGNC:16188
See related
Ensembl:ENSG00000125898 MIM:611393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
F10; C20orf55; bA371L19.3
Expression
Broad expression in skin (RPKM 6.2), spleen (RPKM 5.8) and 23 other tissues See more
Orthologs

Genomic context

See FAM110A in Genome Data Viewer
Location:
20p13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (833715..846279)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (814354..826922)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 52 member 3 Neighboring gene CRISPRi-validated cis-regulatory element chr20.80 Neighboring gene ribosomal protein S10 pseudogene 5 Neighboring gene angiopoietin 4 Neighboring gene uncharacterized LOC105372492 Neighboring gene R-spondin 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2450, MGC4675

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042353.3NP_001035812.1  protein FAM110A

    See identical proteins and their annotated locations for NP_001035812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 encode the same protein.
    Source sequence(s)
    AL118502, BC004222, BI911808, DA915382
    Consensus CDS
    CCDS13008.1
    UniProtKB/Swiss-Prot
    Q9BQ89
    Related
    ENSP00000371367.3, ENST00000381941.8
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus
  2. NM_001289145.2NP_001276074.1  protein FAM110A

    See identical proteins and their annotated locations for NP_001276074.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 encode the same protein.
    Source sequence(s)
    AL118502, BC004222, BI909768, HY035293
    Consensus CDS
    CCDS13008.1
    UniProtKB/Swiss-Prot
    Q9BQ89
    Related
    ENSP00000354163.2, ENST00000304189.6
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus
  3. NM_001289146.2NP_001276075.1  protein FAM110A

    See identical proteins and their annotated locations for NP_001276075.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 encode the same protein.
    Source sequence(s)
    AL118502, BI909945, HY035293
    Consensus CDS
    CCDS13008.1
    UniProtKB/Swiss-Prot
    Q9BQ89
    Related
    ENSP00000371365.1, ENST00000381939.1
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus
  4. NM_001289147.1NP_001276076.1  protein FAM110A

    See identical proteins and their annotated locations for NP_001276076.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 encode the same protein.
    Source sequence(s)
    AL118502, BC004222, CN425669, CX753944
    Consensus CDS
    CCDS13008.1
    UniProtKB/Swiss-Prot
    Q9BQ89
    Related
    ENSP00000445228.1, ENST00000541082.2
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus
  5. NM_031424.6NP_113612.1  protein FAM110A

    See identical proteins and their annotated locations for NP_113612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the same protein as variants 2, 3, 4, 5, and 6.
    Source sequence(s)
    AL118502, AL530841, BC004222
    Consensus CDS
    CCDS13008.1
    UniProtKB/Swiss-Prot
    Q9BQ89
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus
  6. NM_207121.5NP_997004.1  protein FAM110A

    See identical proteins and their annotated locations for NP_997004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 encode the same protein.
    Source sequence(s)
    AL118502, BC004222
    Consensus CDS
    CCDS13008.1
    UniProtKB/Swiss-Prot
    Q9BQ89
    Related
    ENSP00000246100.3, ENST00000246100.3
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    833715..846279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529381.2XP_011527683.1  protein FAM110A isoform X1

    See identical proteins and their annotated locations for XP_011527683.1

    UniProtKB/Swiss-Prot
    Q9BQ89
    Conserved Domains (2) summary
    pfam14160
    Location:182287
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:5104
    FAM110_N; Centrosome-associated N terminus
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