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ODAD4 outer dynein arm docking complex subunit 4 [ Homo sapiens (human) ]

Gene ID: 83538, updated on 23-Nov-2023

Summary

Official Symbol
ODAD4provided by HGNC
Official Full Name
outer dynein arm docking complex subunit 4provided by HGNC
Primary source
HGNC:HGNC:25280
See related
Ensembl:ENSG00000204815 MIM:617095; AllianceGenome:HGNC:25280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTC25
Summary
This gene encodes a tetratricopeptide repeat domain-containing protein that localizes to ciliary axonmenes and plays a role in the docking of the outer dynein arm to cilia. Mutations in this gene cause severely reduced ciliary motility and the disorder CILD35 (ciliary dyskinesia,primary, 35). Primary ciliary dyskinesia is often associated with recurrent respiratory infections, immotile spermatozoa, and situs inversus; an inversion in left-right body symmetry. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
Expression
Biased expression in testis (RPKM 20.2) and lung (RPKM 1.7) See more
Orthologs
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Genomic context

See ODAD4 in Genome Data Viewer
Location:
17q21.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41930617..41966503)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42787128..42823000)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40086870..40118521)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40019607-40020116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8503 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40021860-40022360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40022361-40022861 Neighboring gene kelch like family member 11 Neighboring gene uncharacterized LOC124904005 Neighboring gene MPRA-validated peak2844 silencer Neighboring gene ATP citrate lyase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:40066298-40067497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8504 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8505 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40085993-40086896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40091696-40092276 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:40102816-40102967 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40110957-40111564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40111565-40112170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40112171-40112776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40112777-40113382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40119287-40119844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40119845-40120402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40120403-40120960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12179 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40139962-40140462 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40140463-40140963 Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:40162959-40163488 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:40168666-40169865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12182 Neighboring gene NFKB inhibitor interacting Ras like 2 Neighboring gene zinc finger protein 385C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp434H0115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebrospinal fluid circulation IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium movement IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cilium movement ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in epithelial cilium movement involved in determination of left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in mucociliary clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outer dynein arm assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in outer dynein arm assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to motile cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in 9+0 motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in 9+2 motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
part_of outer dynein arm docking complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
outer dynein arm-docking complex subunit 4
Names
TPR repeat protein 25
tetratricopeptide repeat domain 25
tetratricopeptide repeat protein 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053115.1 RefSeqGene

    Range
    5024..40910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001350319.2NP_001337248.1  outer dynein arm-docking complex subunit 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an internal exon which results in a shift in the reading frame, compared to variant 1. This variant encodes isoform (2) which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC125257, AL136760, CB242540
    Conserved Domains (3) summary
    sd00006
    Location:1641
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:318391
    TPR_12; Tetratricopeptide repeat
    cl26005
    Location:20101
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  2. NM_031421.5NP_113609.1  outer dynein arm-docking complex subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_113609.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC125257, AL136760, CB242540
    Consensus CDS
    CCDS74063.1
    UniProtKB/Swiss-Prot
    Q6NX40, Q6PJ04, Q96NG3, Q9H0K5
    Related
    ENSP00000478589.1, ENST00000377540.6
    Conserved Domains (3) summary
    sd00006
    Location:1641
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:1678
    TPR_11; TPR repeat
    pfam13424
    Location:361429
    TPR_12; Tetratricopeptide repeat

RNA

  1. NR_110662.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC125257, AL136760, BC025390, CB242540
  2. NR_146621.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC125257, BC025390, CB242540, CF593846
  3. NR_146622.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC125257, AL136760, CB242540, CF593846

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    41930617..41966503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    42787128..42823000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)