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FCRL5 Fc receptor like 5 [ Homo sapiens (human) ]

Gene ID: 83416, updated on 11-Jun-2021

Summary

Official Symbol
FCRL5provided by HGNC
Official Full Name
Fc receptor like 5provided by HGNC
Primary source
HGNC:HGNC:18508
See related
Ensembl:ENSG00000143297 MIM:605877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820
Summary
This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Expression
Biased expression in lymph node (RPKM 14.3), spleen (RPKM 11.3) and 8 other tissues See more
Orthologs
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Genomic context

See FCRL5 in Genome Data Viewer
Location:
1q23.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (157513377..157552533, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157483167..157522305, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371456 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9249 Neighboring gene SLAM family member 5 Neighboring gene long intergenic non-protein coding RNA 2772 Neighboring gene Fc receptor like 4 Neighboring gene uncharacterized LOC105371457

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00333, FLJ00397, MGC119590, MGC119592, MGC119593, DKFZp667F216, DKFZp667E2019

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Fc receptor-like protein 5
Names
fc receptor homolog 5
fcR-like protein 5
immune receptor translocation-associated protein 2
immunoglobulin superfamily receptor translocation associated 2 (IRTA2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027723.1 RefSeqGene

    Range
    5006..44144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195388.2NP_001182317.1  Fc receptor-like protein 5 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, resulting in frame-shift, as compared to variant 1. The resulting isoform (2) has a different and longer C-terminus, as compared to isoform 1.
    Source sequence(s)
    AF369794, AL353899, BC101067, BC101068
    UniProtKB/Swiss-Prot
    Q96RD9
    Conserved Domains (4) summary
    cd05752
    Location:23100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:577652
    IG_like; Immunoglobulin like
    pfam13895
    Location:105185
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:565638
    Ig_3; Immunoglobulin domain
  2. NM_031281.3NP_112571.2  Fc receptor-like protein 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_112571.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the dominant isoform (1).
    Source sequence(s)
    AF369794, AL353899, BC101067, BE676280
    Consensus CDS
    CCDS1165.1
    UniProtKB/Swiss-Prot
    Q96RD9
    Related
    ENSP00000354691.3, ENST00000361835.8
    Conserved Domains (4) summary
    cd05752
    Location:23100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:577652
    IG_like; Immunoglobulin like
    pfam13895
    Location:105185
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:565638
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    157513377..157552533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510032.2XP_011508334.1  Fc receptor-like protein 5 isoform X3

    Conserved Domains (4) summary
    cd05752
    Location:23100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:484559
    IG_like; Immunoglobulin like
    pfam13895
    Location:105185
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:472545
    Ig_3; Immunoglobulin domain
  2. XM_011510031.2XP_011508333.1  Fc receptor-like protein 5 isoform X2

    Conserved Domains (4) summary
    cd05752
    Location:23100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:577652
    IG_like; Immunoglobulin like
    pfam13895
    Location:105185
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:565638
    Ig_3; Immunoglobulin domain
  3. XM_011510030.2XP_011508332.1  Fc receptor-like protein 5 isoform X1

    Conserved Domains (3) summary
    smart00410
    Location:492567
    IG_like; Immunoglobulin like
    pfam13895
    Location:20100
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:480553
    Ig_3; Immunoglobulin domain
  4. XM_011510033.2XP_011508335.1  Fc receptor-like protein 5 isoform X4

    Related
    ENSP00000357173.3, ENST00000368190.7
    Conserved Domains (4) summary
    cd05752
    Location:23100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:577652
    IG_like; Immunoglobulin like
    pfam13895
    Location:105185
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:565638
    Ig_3; Immunoglobulin domain
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