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MED25 mediator complex subunit 25 [ Homo sapiens (human) ]

Gene ID: 81857, updated on 5-Aug-2018

Summary

Official Symbol
MED25provided by HGNC
Official Full Name
mediator complex subunit 25provided by HGNC
Primary source
HGNC:HGNC:28845
See related
Ensembl:ENSG00000104973 MIM:610197; Vega:OTTHUMG00000183161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P78; ACID1; ARC92; BVSYS; PTOV2; CMT2B2; TCBAP0758
Summary
This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]
Expression
Broad expression in testis (RPKM 24.2), adrenal (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See MED25 in Genome Data Viewer
Location:
19q13.33
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (49818279..49840384)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50321319..50340237)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene microRNA 6799 Neighboring gene uncharacterized LOC105372435 Neighboring gene fuzzy planar cell polarity protein Neighboring gene microRNA 6800 Neighboring gene PTOV1 antisense RNA 1 Neighboring gene prostate tumor overexpressed 1 Neighboring gene PTOV1 antisense RNA 2 Neighboring gene microRNA 4749

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Basel-Vanagaite-Smirin-Yosef syndrome
MedGen: C4225323 OMIM: 616449 GeneReviews: Not available
Compare labs
Charcot-Marie-Tooth disease type 2B2 Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70671, DKFZp434K0512

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoic acid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoid X receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nuclear transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 25
Names
ARC/mediator transcriptional coactivator subunit
activator interaction domain-containing protein 1
activator-recruited cofactor 92 kDa component
mediator of RNA polymerase II transcription, subunit 25 homolog
prostate-derived protein 78 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017091.1 RefSeqGene

    Range
    5001..23702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_368

mRNA and Protein(s)

  1. NM_030973.3NP_112235.2  mediator of RNA polymerase II transcription subunit 25

    See identical proteins and their annotated locations for NP_112235.2

    Status: REVIEWED

    Source sequence(s)
    BC065297, BG770032, DC410997
    Consensus CDS
    CCDS33075.1
    UniProtKB/Swiss-Prot
    Q71SY5
    Related
    ENSP00000326767.5, OTTHUMP00000271001, ENST00000312865.10, OTTHUMT00000465316
    Conserved Domains (4) summary
    pfam11232
    Location:400545
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:228383
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:664747
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    pfam11265
    Location:13225
    Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    49818279..49840384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527353.1XP_011525655.1  mediator of RNA polymerase II transcription subunit 25 isoform X1

    Conserved Domains (4) summary
    pfam11232
    Location:400545
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:228383
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:664766
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    pfam11265
    Location:13225
    Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
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