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MED25 mediator complex subunit 25 [ Homo sapiens (human) ]

Gene ID: 81857, updated on 4-Oct-2020

Summary

Official Symbol
MED25provided by HGNC
Official Full Name
mediator complex subunit 25provided by HGNC
Primary source
HGNC:HGNC:28845
See related
Ensembl:ENSG00000104973 MIM:610197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P78; ACID1; ARC92; BVSYS; PTOV2; CMT2B2; TCBAP0758
Summary
This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]
Expression
Broad expression in testis (RPKM 24.2), adrenal (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See MED25 in Genome Data Viewer
Location:
19q13.33
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49818289..49840384)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50321319..50340237)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene microRNA 6799 Neighboring gene uncharacterized LOC105372435 Neighboring gene fuzzy planar cell polarity protein Neighboring gene microRNA 6800 Neighboring gene PTOV1 antisense RNA 1 Neighboring gene PTOV1 extended AT-hook containing adaptor protein Neighboring gene PTOV1 antisense RNA 2 Neighboring gene microRNA 4749

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70671, DKFZp434K0512

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoic acid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoid X receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 25
Names
ARC/mediator transcriptional coactivator subunit
activator interaction domain-containing protein 1
activator-recruited cofactor 92 kDa component
mediator of RNA polymerase II transcription, subunit 25 homolog
prostate-derived protein 78 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017091.1 RefSeqGene

    Range
    5001..23702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_368

mRNA and Protein(s)

  1. NM_001378355.1NP_001365284.1  mediator of RNA polymerase II transcription subunit 25 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC006942, AC018766, KC877749
    Related
    ENSP00000470692.3, ENST00000593767.3
  2. NM_030973.4NP_112235.2  mediator of RNA polymerase II transcription subunit 25 isoform 1

    See identical proteins and their annotated locations for NP_112235.2

    Status: REVIEWED

    Source sequence(s)
    BC065297, DC410997
    Consensus CDS
    CCDS33075.1
    UniProtKB/Swiss-Prot
    Q71SY5
    Related
    ENSP00000326767.5, ENST00000312865.10
    Conserved Domains (4) summary
    pfam11232
    Location:400545
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:228383
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:664747
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    pfam11265
    Location:13225
    Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49818289..49840384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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