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NETO1 neuropilin and tolloid like 1 [ Homo sapiens (human) ]

Gene ID: 81832, updated on 22-Sep-2022

Summary

Official Symbol
NETO1provided by HGNC
Official Full Name
neuropilin and tolloid like 1provided by HGNC
Primary source
HGNC:HGNC:13823
See related
Ensembl:ENSG00000166342 MIM:607973; AllianceGenome:HGNC:13823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCTL1; BTCL1
Summary
This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017]
Expression
Biased expression in brain (RPKM 5.4) and spleen (RPKM 0.5) See more
Orthologs
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Genomic context

See NETO1 in Genome Data Viewer
Location:
18q22.3
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (72742314..72867987, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (72963774..73089445, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (70409549..70535222, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372189 Neighboring gene cerebellin 2 precursor Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 11 Neighboring gene RNA, 5S ribosomal pseudogene 460 Neighboring gene microRNA 548av Neighboring gene NETO1 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 3365 Neighboring gene long intergenic non-protein coding RNA 2864

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
EBI GWAS Catalog
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
EBI GWAS Catalog
The genetic architecture of economic and political preferences.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41325

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ionotropic glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in excitatory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic density membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
neuropilin and tolloid-like protein 1
Names
brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1
neuropilin (NRP) and tolloid (TLL)-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201465.3NP_001188394.2  neuropilin and tolloid-like protein 1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC023301, AC091138
    Consensus CDS
    CCDS12000.1
    UniProtKB/Swiss-Prot
    Q8TDF4
    UniProtKB/TrEMBL
    A0A024R375
    Related
    ENSP00000464312.1, ENST00000583169.5
    Conserved Domains (2) summary
    cd00041
    Location:51154
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl00104
    Location:291326
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  2. NM_001354017.2NP_001340946.2  neuropilin and tolloid-like protein 1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC023301, AC091138
    Consensus CDS
    CCDS12000.1
    UniProtKB/Swiss-Prot
    Q8TDF4
    UniProtKB/TrEMBL
    A0A024R375
    Conserved Domains (2) summary
    cd00041
    Location:51154
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl00104
    Location:291326
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  3. NM_001354018.2NP_001340947.2  neuropilin and tolloid-like protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC023301, AC091138
    Conserved Domains (2) summary
    cd00041
    Location:58144
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl00104
    Location:149184
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  4. NM_001354020.2NP_001340949.2  neuropilin and tolloid-like protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC023301, AC091138
    Conserved Domains (2) summary
    cd00041
    Location:43146
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl00104
    Location:283318
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  5. NM_001354021.2NP_001340950.1  neuropilin and tolloid-like protein 1 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC091138
    Conserved Domains (1) summary
    cd00041
    Location:51154
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  6. NM_001354022.2NP_001340951.1  neuropilin and tolloid-like protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC091138
    Conserved Domains (1) summary
    cd00041
    Location:43146
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  7. NM_138966.5NP_620416.2  neuropilin and tolloid-like protein 1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC023301, AC091138
    Consensus CDS
    CCDS12000.1
    UniProtKB/Swiss-Prot
    Q8TDF4
    UniProtKB/TrEMBL
    A0A024R375
    Related
    ENSP00000313088.6, ENST00000327305.11
    Conserved Domains (2) summary
    cd00041
    Location:51154
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl00104
    Location:291326
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  8. NM_138999.2NP_620552.1  neuropilin and tolloid-like protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_620552.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as sNETO1, encodes isoform 1 and was described by Stohr et. al (PMID:11943477).
    Source sequence(s)
    AC091138, AF448839
    Consensus CDS
    CCDS42444.1
    UniProtKB/Swiss-Prot
    Q8TDF5
    Related
    ENSP00000381024.1, ENST00000397929.5
    Conserved Domains (1) summary
    cd00041
    Location:50153
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

RNA

  1. NR_148694.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC023301, AC091138
  2. NR_148695.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC023301, AC091138

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    72742314..72867987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026018.2XP_016881507.1  neuropilin and tolloid-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8TDF4, Q8TDF5
    UniProtKB/TrEMBL
    A0A024R375
    Conserved Domains (2) summary
    cd00041
    Location:51154
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl00104
    Location:291326
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  2. XM_017026017.2XP_016881506.1  neuropilin and tolloid-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8TDF4, Q8TDF5
    UniProtKB/TrEMBL
    A0A024R375
    Conserved Domains (2) summary
    cd00041
    Location:51154
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl00104
    Location:291326
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  3. XM_047437876.1XP_047293832.1  neuropilin and tolloid-like protein 1 isoform X2

  4. XM_017026022.2XP_016881511.1  neuropilin and tolloid-like protein 1 isoform X3

  5. XM_017026023.2XP_016881512.1  neuropilin and tolloid-like protein 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    72963774..73089445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153181.2: Suppressed sequence

    Description
    NM_153181.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.