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OR12D3 olfactory receptor family 12 subfamily D member 3 [ Homo sapiens (human) ]

Gene ID: 81797, updated on 22-Sep-2022

Summary

Official Symbol
OR12D3provided by HGNC
Official Full Name
olfactory receptor family 12 subfamily D member 3provided by HGNC
Primary source
HGNC:HGNC:13963
See related
Ensembl:ENSG00000112462 AllianceGenome:HGNC:13963
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hs6M1-27
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR12D3 in Genome Data Viewer
Location:
6p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (29373423..29375291, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (29248211..29250079, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29341200..29343068, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375005 Neighboring gene DEAD-box helicase 6 pseudogene 1 Neighboring gene olfactory receptor family 5 subfamily V member 1 Neighboring gene olfactory receptor family 12 subfamily D member 2 Neighboring gene olfactory receptor family 12 subfamily D member 1 (gene/pseudogene)

Genomic regions, transcripts, and products

Phenotypes

EBI GWAS Catalog

Description
Common variation contributes to the genetic architecture of social communication traits.
EBI GWAS Catalog
Genome-wide association study of retinopathy in individuals without diabetes.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119267, MGC125888

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
olfactory receptor 12D3
Names
olfactory receptor OR6-27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030959.3NP_112221.1  olfactory receptor 12D3

    See identical proteins and their annotated locations for NP_112221.1

    Status: PROVISIONAL

    Source sequence(s)
    AL662781
    Consensus CDS
    CCDS4658.1
    UniProtKB/Swiss-Prot
    Q6IF23, Q9UGF7
    UniProtKB/TrEMBL
    A8MXE9, D2XT27
    Related
    ENSP00000380023.3, ENST00000396806.3
    Conserved Domains (1) summary
    cd15915
    Location:23293
    7tmA_OR12D-like; olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    29373423..29375291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    860028..861896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    639071..640939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    638713..640581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    638936..640804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    682548..684416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    29248211..29250079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)