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PPP1R14C protein phosphatase 1 regulatory inhibitor subunit 14C [ Homo sapiens (human) ]

Gene ID: 81706, updated on 13-Mar-2020

Summary

Official Symbol
PPP1R14Cprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 14Cprovided by HGNC
Primary source
HGNC:HGNC:14952
See related
Ensembl:ENSG00000198729 MIM:613242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KEPI; NY-BR-81; CPI17-like
Summary
The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]
Expression
Biased expression in thyroid (RPKM 22.2), heart (RPKM 17.2) and 9 other tissues See more
Orthologs

Genomic context

See PPP1R14C in Genome Data Viewer
Location:
6q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (150143044..150250392)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150464188..150571528)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene prohibitin pseudogene 1 Neighboring gene UL16 binding protein 3 Neighboring gene VISTA enhancer hs1922 Neighboring gene uncharacterized LOC105378054 Neighboring gene CRISPRi-validated cis-regulatory element chr6.5240 Neighboring gene RNA, U4 small nuclear 7, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
NHGRI GWA Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein serine/threonine phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 14C
Names
PKC-potentiated PP1 inhibitory protein
kinase C-enhanced PP1 inhibitor
kinase-enhanced PP1 inhibitor
serologically defined breast cancer antigen NY-BR-81

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030949.3NP_112211.1  protein phosphatase 1 regulatory subunit 14C

    See identical proteins and their annotated locations for NP_112211.1

    Status: VALIDATED

    Source sequence(s)
    AF308297, AK096272, AL096708, AL355497, CB994599
    Consensus CDS
    CCDS5226.1
    UniProtKB/Swiss-Prot
    Q8TAE6
    Related
    ENSP00000355260.4, ENST00000361131.5
    Conserved Domains (1) summary
    pfam05361
    Location:71165
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    150143044..150250392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267152.5XP_005267209.1  protein phosphatase 1 regulatory subunit 14C isoform X1

    Conserved Domains (1) summary
    pfam05361
    Location:66108
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor
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