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CAMK2D calcium/calmodulin dependent protein kinase II delta [ Homo sapiens (human) ]

Gene ID: 817, updated on 9-Feb-2020

Summary

Official Symbol
CAMK2Dprovided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase II deltaprovided by HGNC
Primary source
HGNC:HGNC:1462
See related
Ensembl:ENSG00000145349 MIM:607708
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMKD
Summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in heart (RPKM 23.1), brain (RPKM 14.9) and 24 other tissues See more
Orthologs

Genomic context

See CAMK2D in Genome Data Viewer
Location:
4q26
Exon count:
26
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (113451032..113762177, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (114372188..114683669, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377374 Neighboring gene RNA, 7SL, cytoplasmic 184, pseudogene Neighboring gene RNA, U1 small nuclear 138, pseudogene Neighboring gene FOXA motif-containing MPRA enhancer 297 Neighboring gene uncharacterized LOC105377375 Neighboring gene arylsulfatase family member J Neighboring gene uncharacterized LOC107986305

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Genome-wide Association Study of Survival in Early-stage Non-Small Cell Lung Cancer.
NHGRI GWA Catalog
White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC44911, DKFZp686I2288, DKFZp686G23119

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
titin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cardiac muscle cell contraction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to calcium ion TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of sodium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cardiac muscle cell action potential involved in regulation of contraction IC
Inferred by Curator
more info
PubMed 
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC
Inferred by Curator
more info
PubMed 
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion TAS
Traceable Author Statement
more info
PubMed 
regulation of cell communication by electrical coupling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell communication by electrical coupling involved in cardiac conduction IC
Inferred by Curator
more info
PubMed 
regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cellular localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of heart contraction TAS
Traceable Author Statement
more info
PubMed 
regulation of heart rate by cardiac conduction IC
Inferred by Curator
more info
PubMed 
regulation of histone deacetylase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of membrane depolarization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of relaxation of cardiac muscle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of ryanodine-sensitive calcium-release channel activity TAS
Traceable Author Statement
more info
PubMed 
regulation of the force of heart contraction TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
relaxation of cardiac muscle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
calcium- and calmodulin-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit delta
Names
CaM kinase II delta subunit
CaM-kinase II delta chain
CaMK-II delta subunit
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
calcium/calmodulin-dependent protein kinase type II delta chain
NP_001212.2
NP_001308495.1
NP_001308496.1
NP_001308497.1
NP_001308498.1
NP_001308499.1
NP_001308500.1
NP_001308501.1
NP_001308502.1
NP_001308503.1
NP_001308504.1
NP_001308505.1
NP_001308506.1
NP_001308507.1
NP_001308508.1
NP_001308509.1
NP_001308510.1
NP_001308511.1
NP_001308512.1
NP_001308513.1
NP_001308514.1
NP_001308515.1
NP_001308516.1
NP_001308517.1
NP_001308518.1
NP_001308519.1
NP_001308520.1
NP_001308521.1
NP_742112.1
NP_742113.1
NP_742125.1
NP_742126.1
NP_742127.1
XP_005263310.1
XP_005263311.1
XP_006714393.1
XP_011530591.1
XP_011530592.1
XP_011530593.1
XP_011530594.1
XP_011530597.1
XP_016864161.1
XP_016864162.1
XP_016864163.1
XP_016864164.1
XP_016864165.1
XP_016864166.1
XP_016864167.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001221.4NP_001212.2  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3

    See identical proteins and their annotated locations for NP_001212.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AB209288, AC093900, AI057019, AK055642, CF551834, DA113081
    Consensus CDS
    CCDS3703.1
    UniProtKB/Swiss-Prot
    Q13557
    UniProtKB/TrEMBL
    A0A024RDK3
    Related
    ENSP00000339740.5, ENST00000342666.9
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. NM_001321566.2NP_001308495.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/Swiss-Prot
    Q13557
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. NM_001321567.2NP_001308496.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS82948.1
    UniProtKB/TrEMBL
    E9PBG7
    Related
    ENSP00000424245.1, ENST00000505990.5
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  4. NM_001321568.2NP_001308497.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:371498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  5. NM_001321569.2NP_001308498.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  6. NM_001321570.2NP_001308499.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  7. NM_001321571.2NP_001308500.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS82949.1
    UniProtKB/TrEMBL
    E9PF82
    Related
    ENSP00000425824.1, ENST00000511664.6
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  8. NM_001321572.2NP_001308501.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  9. NM_001321573.2NP_001308502.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/Swiss-Prot
    Q13557
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:371498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  10. NM_001321574.2NP_001308503.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS82950.1
    UniProtKB/TrEMBL
    D6R938
    Related
    ENSP00000423677.1, ENST00000514328.5
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:345472
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  11. NM_001321575.2NP_001308504.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  12. NM_001321576.2NP_001308505.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:345472
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  13. NM_001321577.2NP_001308506.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:359486
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  14. NM_001321578.2NP_001308507.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 18 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) and variant 26 both encode the same isoform (18).
    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    pfam08332
    Location:164291
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1107
    PKc_like; Protein Kinases, catalytic domain
  15. NM_001321579.2NP_001308508.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  16. NM_001321580.2NP_001308509.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/Swiss-Prot
    Q13557
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:366493
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  17. NM_001321581.2NP_001308510.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:8264
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:321448
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  18. NM_001321582.2NP_001308511.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  19. NM_001321583.2NP_001308512.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  20. NM_001321584.2NP_001308513.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:359486
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  21. NM_001321585.2NP_001308514.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 18 precursor

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (26) and variant 19 both encode the same isoform (18).
    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    pfam08332
    Location:164291
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1107
    PKc_like; Protein Kinases, catalytic domain
  22. NM_001321586.2NP_001308515.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:379506
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  23. NM_001321587.2NP_001308516.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:371498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  24. NM_001321588.2NP_001308517.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:359486
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  25. NM_001321589.2NP_001308518.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS47127.1
    UniProtKB/Swiss-Prot
    Q13557
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  26. NM_001321590.2NP_001308519.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  27. NM_001321591.2NP_001308520.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:371498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  28. NM_001321592.2NP_001308521.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC004168
    Conserved Domains (1) summary
    cl21453
    Location:1256
    PKc_like; Protein Kinases, catalytic domain
  29. NM_172114.1NP_742112.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 5

    See identical proteins and their annotated locations for NP_742112.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the 3' coding region, compared to variant 3. The resulting isoform (5) has a shorter C-terminus, compared to isoform 3.
    Source sequence(s)
    AB209288, AI057019, BC032784, DA113081
    Consensus CDS
    CCDS47127.1
    UniProtKB/Swiss-Prot
    Q13557
    Related
    ENSP00000378030.3, ENST00000394522.7
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  30. NM_172115.2NP_742113.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1

    See identical proteins and their annotated locations for NP_742113.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 3' coding region, compared to variant 3. The resulting isoform (1) has a shorter C-terminus, compared to isoform 3. Isoform 1 is encoded by transcript variants 1 and 4.
    Source sequence(s)
    AB209288, AI057019, AK025368, BC032784, DA113081
    Consensus CDS
    CCDS3704.1
    UniProtKB/Swiss-Prot
    Q13557
    Related
    ENSP00000369098.2, ENST00000379773.6
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  31. NM_172127.2NP_742125.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1

    See identical proteins and their annotated locations for NP_742125.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has multiple differences in the 3' coding region, compared to variant 3. The resulting isoform (1) has a shorter C-terminus, compared to isoform 3. Isoform 1 is encoded by transcript variants 1 and 4.
    Source sequence(s)
    AB209288, AC093900, AI057019, AK025368, DA113081
    Consensus CDS
    CCDS3704.1
    UniProtKB/Swiss-Prot
    Q13557
    Related
    ENSP00000296402.5, ENST00000296402.9
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  32. NM_172128.3NP_742126.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2

    See identical proteins and their annotated locations for NP_742126.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 3. The resulting isoform (2) has a shorter C-terminus, compared to isoform 3.
    Source sequence(s)
    AB209288, AC093900, AI057019, AK055642, DA113081
    Consensus CDS
    CCDS43263.1
    UniProtKB/Swiss-Prot
    Q13557
    Related
    ENSP00000378032.3, ENST00000394524.7
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  33. NM_172129.1NP_742127.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 4

    See identical proteins and their annotated locations for NP_742127.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the 3' coding region, compared to variant 3. The resulting isoform (4) has a shorter C-terminus, compared to isoform 3.
    Source sequence(s)
    AB209288, AI057019, AY987011, BC032784, DA113081
    Consensus CDS
    CCDS54797.1
    UniProtKB/Swiss-Prot
    Q13557
    Related
    ENSP00000422566.1, ENST00000508738.5
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    113451032..113762177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008673.2XP_016864162.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:359486
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. XM_017008677.2XP_016864166.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X10

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:359486
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. XM_017008674.2XP_016864163.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X5

  4. XM_005263254.4XP_005263311.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2

    See identical proteins and their annotated locations for XP_005263311.1

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:379506
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  5. XM_006714330.3XP_006714393.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X12

    See identical proteins and their annotated locations for XP_006714393.1

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  6. XM_017008672.2XP_016864161.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  7. XM_011532295.2XP_011530597.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X7

    See identical proteins and their annotated locations for XP_011530597.1

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  8. XM_017008678.2XP_016864167.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X13

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:345472
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  9. XM_005263253.4XP_005263310.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1

    See identical proteins and their annotated locations for XP_005263310.1

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:379506
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  10. XM_011532290.2XP_011530592.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X8

    See identical proteins and their annotated locations for XP_011530592.1

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:356483
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  11. XM_011532289.2XP_011530591.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6

    See identical proteins and their annotated locations for XP_011530591.1

    UniProtKB/Swiss-Prot
    Q13557
    Related
    ENSP00000423482.1, ENST00000515496.5
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  12. XM_011532291.2XP_011530593.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X11

    See identical proteins and their annotated locations for XP_011530593.1

    UniProtKB/Swiss-Prot
    Q13557
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  13. XM_017008675.2XP_016864164.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9

    Conserved Domains (3) summary
    smart00220
    Location:8233
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:8264
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:341468
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  14. XM_017008676.1XP_016864165.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9

    Conserved Domains (3) summary
    smart00220
    Location:8233
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:8264
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:341468
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  15. XM_011532292.2XP_011530594.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X14

    See identical proteins and their annotated locations for XP_011530594.1

    Conserved Domains (3) summary
    smart00220
    Location:1143
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:251378
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
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