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CAMK2D calcium/calmodulin dependent protein kinase II delta [ Homo sapiens (human) ]

Gene ID: 817, updated on 19-Feb-2024

Summary

Official Symbol
CAMK2Dprovided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase II deltaprovided by HGNC
Primary source
HGNC:HGNC:1462
See related
Ensembl:ENSG00000145349 MIM:607708; AllianceGenome:HGNC:1462
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMKD
Summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in heart (RPKM 23.1), brain (RPKM 14.9) and 24 other tissues See more
Orthologs
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Genomic context

See CAMK2D in Genome Data Viewer
Location:
4q26
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (113451032..113761738, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (116759793..117070469, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (114372188..114682894, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377374 Neighboring gene RNA, 7SL, cytoplasmic 184, pseudogene Neighboring gene RNA, U1 small nuclear 138, pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:114373445-114373992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15644 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15645 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_72235 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:114481688-114482887 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_72247 Neighboring gene Sharpr-MPRA regulatory region 13729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15646 Neighboring gene Sharpr-MPRA regulatory region 15168 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:114566848-114567352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15647 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:114683084-114683622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:114683623-114684161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21839 Neighboring gene uncharacterized LOC105377375 Neighboring gene NANOG hESC enhancer GRCh37_chr4:114805704-114806205 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:114839688-114840887 Neighboring gene arylsulfatase family member J

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
Genome-wide Association Study of Survival in Early-stage Non-Small Cell Lung Cancer.
EBI GWAS Catalog
White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC44911, DKFZp686I2288, DKFZp686G23119

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables titin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in cardiac muscle cell contraction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cellular response to calcium ion TAS
Traceable Author Statement
more info
PubMed 
involved_in endoplasmic reticulum calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of sodium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction IC
Inferred by Curator
more info
PubMed 
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC
Inferred by Curator
more info
PubMed 
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell communication by electrical coupling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction IC
Inferred by Curator
more info
PubMed 
involved_in regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cellular localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart contraction TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of heart rate by cardiac conduction IC
Inferred by Curator
more info
PubMed 
involved_in regulation of membrane depolarization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of relaxation of cardiac muscle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of ryanodine-sensitive calcium-release channel activity TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of the force of heart contraction TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
involved_in relaxation of cardiac muscle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
part_of calcium- and calmodulin-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit delta
Names
CaM kinase II delta subunit
CaM-kinase II delta chain
CaMK-II delta subunit
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
calcium/calmodulin-dependent protein kinase type II delta chain
NP_001212.2
NP_001308495.1
NP_001308496.1
NP_001308497.1
NP_001308498.1
NP_001308499.1
NP_001308500.1
NP_001308501.1
NP_001308502.1
NP_001308503.1
NP_001308504.1
NP_001308505.1
NP_001308506.1
NP_001308507.1
NP_001308508.1
NP_001308509.1
NP_001308510.1
NP_001308511.1
NP_001308512.1
NP_001308513.1
NP_001308514.1
NP_001308515.1
NP_001308516.1
NP_001308517.1
NP_001308518.1
NP_001308519.1
NP_001308520.1
NP_001308521.1
NP_001383893.1
NP_001383894.1
NP_001383895.1
NP_001383896.1
NP_001386784.1
NP_001386785.1
NP_001386786.1
NP_001386787.1
NP_001386788.1
NP_001386789.1
NP_001386790.1
NP_001386791.1
NP_001386792.1
NP_001386793.1
NP_001386794.1
NP_742112.1
NP_742113.1
NP_742125.1
NP_742126.1
NP_742127.1
XP_011530594.1
XP_011530597.1
XP_016864163.1
XP_047272176.1
XP_047272177.1
XP_047272178.1
XP_047272179.1
XP_054206906.1
XP_054206907.1
XP_054206908.1
XP_054206909.1
XP_054206910.1
XP_054206911.1
XP_054206912.1
XP_054206913.1
XP_054206914.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001221.4NP_001212.2  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3

    See identical proteins and their annotated locations for NP_001212.2

    Status: REVIEWED

    Source sequence(s)
    AB209288, AC093900, AI057019, AK055642, CF551834, DA113081
    Consensus CDS
    CCDS3703.1
    UniProtKB/Swiss-Prot
    A8MVS8, Q13557, Q52PK4, Q59G21, Q8N553, Q9UGH6, Q9UQE9
    UniProtKB/TrEMBL
    B7Z2B0
    Related
    ENSP00000339740.5, ENST00000342666.9
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. NM_001321566.2NP_001308495.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS93607.1
    UniProtKB/TrEMBL
    B7Z2B0
    Related
    ENSP00000514099.1, ENST00000699047.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. NM_001321567.2NP_001308496.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS82948.1
    UniProtKB/TrEMBL
    A0A8V8TND4, E9PBG7
    Related
    ENSP00000424245.1, ENST00000505990.5
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  4. NM_001321568.2NP_001308497.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:371498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  5. NM_001321569.2NP_001308498.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    B7Z2B0
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  6. NM_001321570.2NP_001308499.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS93608.1
    UniProtKB/TrEMBL
    A0A8V8TND4, A0A8V8TPJ8
    Related
    ENSP00000514341.1, ENST00000699376.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  7. NM_001321571.2NP_001308500.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) encodes isoform (11, also known as delta 1).
    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS82949.1
    UniProtKB/TrEMBL
    B7Z2B0, E9PF82
    Related
    ENSP00000425824.1, ENST00000511664.6
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  8. NM_001321572.2NP_001308501.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) encodes isoform (12, also known as delta 5).
    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  9. NM_001321573.2NP_001308502.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) encodes isoform (13, also known as delta 11).
    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS93612.1
    UniProtKB/TrEMBL
    B7Z2B0
    Related
    ENSP00000514100.1, ENST00000699048.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:371498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  10. NM_001321574.2NP_001308503.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) encodes isoform (14, also known as delta 2).
    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS82950.1
    UniProtKB/TrEMBL
    B7Z2B0, D6R938
    Related
    ENSP00000514343.1, ENST00000699378.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:345472
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  11. NM_001321575.2NP_001308504.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  12. NM_001321576.2NP_001308505.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 16

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) encodes isoform (16, also known as delta 6).
    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS93603.1
    UniProtKB/TrEMBL
    A0A8V8TN88, A0A8V8TND4
    Related
    ENSP00000514375.1, ENST00000699417.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:345472
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  13. NM_001321577.2NP_001308506.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 17

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) encodes isoform (17, also known as delta 10).
    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS93601.1
    UniProtKB/TrEMBL
    A0A8V8TND4, A0A8V8TPY4
    Related
    ENSP00000514338.1, ENST00000699373.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:359486
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  14. NM_001321578.2NP_001308507.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    pfam08332
    Location:164291
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1107
    PKc_like; Protein Kinases, catalytic domain
  15. NM_001321579.2NP_001308508.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
    Related
    ENSP00000514376.1, ENST00000699418.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:380507
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  16. NM_001321580.2NP_001308509.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 20

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) encodes isoform (20, also known as delta 4).
    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    B7Z2B0
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:366493
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  17. NM_001321581.2NP_001308510.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
    Conserved Domains (2) summary
    cd14086
    Location:8264
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:321448
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  18. NM_001321582.2NP_001308511.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 22

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) encodes isoform (22, also known as delta 7).
    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  19. NM_001321583.2NP_001308512.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS93602.1
    UniProtKB/TrEMBL
    A0A8V8TNA7, A0A8V8TND4
    Related
    ENSP00000514345.1, ENST00000699380.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  20. NM_001321584.2NP_001308513.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS93604.1
    UniProtKB/TrEMBL
    A0A8V8TN60, A0A8V8TND4
    Related
    ENSP00000514339.1, ENST00000699374.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:359486
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  21. NM_001321585.2NP_001308514.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Conserved Domains (2) summary
    pfam08332
    Location:164291
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1107
    PKc_like; Protein Kinases, catalytic domain
  22. NM_001321586.2NP_001308515.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS93606.1
    UniProtKB/TrEMBL
    A0A8V8TNA1, A0A8V8TND4
    Related
    ENSP00000514340.1, ENST00000699375.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:379506
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  23. NM_001321587.2NP_001308516.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS93611.1
    UniProtKB/TrEMBL
    A0A8V8TND4, A0A994J516
    Related
    ENSP00000516209.1, ENST00000706057.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:371498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  24. NM_001321588.2NP_001308517.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29) encodes isoform (27, also known as delta 9).
    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS93605.1
    UniProtKB/TrEMBL
    A0A8V8TN65, B7Z2B0
    Related
    ENSP00000514344.1, ENST00000699379.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:359486
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  25. NM_001321589.2NP_001308518.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS47127.1
    UniProtKB/TrEMBL
    A0A8V8TND4
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  26. NM_001321590.2NP_001308519.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  27. NM_001321591.2NP_001308520.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS93610.1
    UniProtKB/TrEMBL
    A0A8V8TND4, A0A994J5B0
    Related
    ENSP00000516207.1, ENST00000706055.1
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:371498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  28. NM_001321592.2NP_001308521.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC004168
    UniProtKB/TrEMBL
    A0A8V8TQ10
    Conserved Domains (1) summary
    cl21453
    Location:1256
    PKc_like; Protein Kinases, catalytic domain
  29. NM_001396964.1NP_001383893.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    B7Z2B0
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  30. NM_001396965.1NP_001383894.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    Consensus CDS
    CCDS93609.1
    UniProtKB/TrEMBL
    B7Z2B0
    Related
    ENSP00000423482.1, ENST00000515496.5
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  31. NM_001396966.1NP_001383895.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    B7Z2B0
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:356483
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  32. NM_001396967.1NP_001383896.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:345472
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  33. NM_001399855.1NP_001386784.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
  34. NM_001399856.1NP_001386785.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
  35. NM_001399857.1NP_001386786.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
  36. NM_001399858.1NP_001386787.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
  37. NM_001399859.1NP_001386788.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    B7Z2B0
  38. NM_001399860.1NP_001386789.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
  39. NM_001399861.1NP_001386790.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
  40. NM_001399862.1NP_001386791.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
    UniProtKB/TrEMBL
    A0A8V8TND4
  41. NM_001399863.1NP_001386792.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
  42. NM_001399864.1NP_001386793.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
  43. NM_001399865.1NP_001386794.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC004056, AC004168, AC093900
  44. NM_172114.2NP_742112.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 5

    See identical proteins and their annotated locations for NP_742112.1

    Status: REVIEWED

    Source sequence(s)
    AB209288, AI057019, BC032784, DA113081
    Consensus CDS
    CCDS47127.1
    UniProtKB/TrEMBL
    A0A8V8TND4
    Related
    ENSP00000378030.3, ENST00000394522.7
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:360487
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  45. NM_172115.3NP_742113.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1

    See identical proteins and their annotated locations for NP_742113.1

    Status: REVIEWED

    Source sequence(s)
    AB209288, AI057019, AK025368, BC032784, DA113081
    Consensus CDS
    CCDS3704.1
    UniProtKB/TrEMBL
    A0A8V8TND4
    Related
    ENSP00000369098.2, ENST00000379773.6
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  46. NM_172127.3NP_742125.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1

    See identical proteins and their annotated locations for NP_742125.1

    Status: REVIEWED

    Source sequence(s)
    AB209288, AC093900, AI057019, AK025368, DA113081
    Consensus CDS
    CCDS3704.1
    UniProtKB/TrEMBL
    A0A8V8TND4
    Related
    ENSP00000296402.5, ENST00000296402.9
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  47. NM_172128.3NP_742126.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2

    See identical proteins and their annotated locations for NP_742126.1

    Status: REVIEWED

    Source sequence(s)
    AB209288, AC093900, AI057019, AK055642, DA113081
    Consensus CDS
    CCDS43263.1
    UniProtKB/TrEMBL
    A0A8V8TND4
    Related
    ENSP00000378032.3, ENST00000394524.7
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  48. NM_172129.2NP_742127.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 4

    See identical proteins and their annotated locations for NP_742127.1

    Status: REVIEWED

    Source sequence(s)
    AB209288, AI057019, AY987011, BC032784, DA113081
    Consensus CDS
    CCDS54797.1
    UniProtKB/TrEMBL
    A0A8V8TND4
    Related
    ENSP00000422566.1, ENST00000508738.5
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    113451032..113761738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008674.3XP_016864163.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4

    UniProtKB/TrEMBL
    A0A8V8TND4
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:379506
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. XM_047416222.1XP_047272178.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3

    UniProtKB/TrEMBL
    B7Z2B0
    Related
    ENSP00000514347.1, ENST00000699382.1
  3. XM_047416221.1XP_047272177.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2

    UniProtKB/TrEMBL
    B7Z2B0
  4. XM_047416223.1XP_047272179.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6

    UniProtKB/TrEMBL
    B7Z2B0
  5. XM_011532295.3XP_011530597.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X5

    See identical proteins and their annotated locations for XP_011530597.1

    UniProtKB/TrEMBL
    B7Z2B0
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  6. XM_047416220.1XP_047272176.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1

    UniProtKB/TrEMBL
    B7Z2B0
  7. XM_011532292.3XP_011530594.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X7

    See identical proteins and their annotated locations for XP_011530594.1

    Conserved Domains (2) summary
    pfam08332
    Location:251378
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    116759793..117070469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350934.1XP_054206909.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4

    UniProtKB/TrEMBL
    A0A8V8TND4
  2. XM_054350933.1XP_054206908.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3

    UniProtKB/TrEMBL
    B7Z2B0
  3. XM_054350932.1XP_054206907.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2

    UniProtKB/TrEMBL
    B7Z2B0
  4. XM_054350936.1XP_054206911.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6

    UniProtKB/TrEMBL
    B7Z2B0
  5. XM_054350935.1XP_054206910.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X5

    UniProtKB/TrEMBL
    B7Z2B0
  6. XM_054350931.1XP_054206906.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1

    UniProtKB/TrEMBL
    B7Z2B0
  7. XM_054350937.1XP_054206912.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X8

    UniProtKB/TrEMBL
    B7Z2B0
  8. XM_054350939.1XP_054206914.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X7

  9. XM_054350938.1XP_054206913.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9

    UniProtKB/TrEMBL
    A0A8V8TND4