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AMN amnion associated transmembrane protein [ Homo sapiens (human) ]

Gene ID: 81693, updated on 22-Sep-2022

Summary

Official Symbol
AMNprovided by HGNC
Official Full Name
amnion associated transmembrane proteinprovided by HGNC
Primary source
HGNC:HGNC:14604
See related
Ensembl:ENSG00000166126 MIM:605799; AllianceGenome:HGNC:14604
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGS2; PRO1028; amnionless
Summary
The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney (RPKM 39.0), small intestine (RPKM 30.0) and 4 other tissues See more
Orthologs
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Genomic context

See AMN in Genome Data Viewer
Location:
14q32.32
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102922663..102930842)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97158908..97167087)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103389000..103397179)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene TNF receptor associated factor 3 Neighboring gene RNA, U6 small nuclear 1316, pseudogene Neighboring gene CDC42 binding protein kinase beta Neighboring gene Sharpr-MPRA regulatory region 6354 Neighboring gene ribosomal protein L13 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cargo receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cobalamin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cobalamin transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in renal protein absorption IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border membrane IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microvillus membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
protein amnionless
Names
amnionless homolog
visceral endoderm-specific type 1 transmembrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008276.2 RefSeqGene

    Range
    5001..13187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_642

mRNA and Protein(s)

  1. NM_030943.4NP_112205.2  protein amnionless precursor

    See identical proteins and their annotated locations for NP_112205.2

    Status: REVIEWED

    Source sequence(s)
    AF328788, AL117209, BC029948, CB306421
    Consensus CDS
    CCDS9977.1
    UniProtKB/Swiss-Prot
    Q6UX83, Q9BXJ7
    Related
    ENSP00000299155.6, ENST00000299155.10
    Conserved Domains (1) summary
    pfam14828
    Location:22447
    Amnionless

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    102922663..102930842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537202.4XP_011535504.1  protein amnionless isoform X1

    See identical proteins and their annotated locations for XP_011535504.1

    UniProtKB/TrEMBL
    B3KP64
    Conserved Domains (1) summary
    pfam14828
    Location:1393
    Amnionless; Amnionless
  2. XM_011537203.4XP_011535505.1  protein amnionless isoform X1

    See identical proteins and their annotated locations for XP_011535505.1

    UniProtKB/TrEMBL
    B3KP64
    Related
    ENST00000541086.5
    Conserved Domains (1) summary
    pfam14828
    Location:1393
    Amnionless; Amnionless

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    97158908..97167087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)