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CSRNP2 cysteine and serine rich nuclear protein 2 [ Homo sapiens (human) ]

Gene ID: 81566, updated on 23-Nov-2023

Summary

Official Symbol
CSRNP2provided by HGNC
Official Full Name
cysteine and serine rich nuclear protein 2provided by HGNC
Primary source
HGNC:HGNC:16006
See related
Ensembl:ENSG00000110925 MIM:620404; AllianceGenome:HGNC:16006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C12orf2; PPP1R72; TAIP-12; C12orf22; FAM130A1
Summary
The protein encoded by this gene belongs to the CSRNP family of nuclear proteins that share conserved regions, including cysteine- and serine- rich regions, a basic domain, a transcriptional activation domain, and bind the sequence 'AGAGTG', thus have the hallmark of transcription factors. Studies in mice suggest that these genes may have redundant functions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Broad expression in testis (RPKM 16.6), brain (RPKM 11.7) and 25 other tissues See more
Orthologs
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Genomic context

See CSRNP2 in Genome Data Viewer
Location:
12q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (51061205..51083596, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (51024095..51046514, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51454988..51477379, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 11 member 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51419127-51419740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51419741-51420352 Neighboring gene RNA, U6 small nuclear 87, pseudogene Neighboring gene RNA, U6 small nuclear 1273, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51441816-51442354 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51442355-51442893 Neighboring gene LETM1 domain containing 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51463214-51463714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51477804-51478430 Neighboring gene transcription factor CP2 Neighboring gene ribosomal protein L35a pseudogene 29 Neighboring gene PHB1 pseudogene 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ25576

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
cysteine/serine-rich nuclear protein 2
Names
CSRNP-2
TGF-beta-induced apoptosis protein 12
family with sequence similarity 130, member A1
protein phosphatase 1, regulatory subunit 72

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030809.3NP_110436.1  cysteine/serine-rich nuclear protein 2

    See identical proteins and their annotated locations for NP_110436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AJ298133, BM975428, DB059091
    Consensus CDS
    CCDS8807.1
    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
    Related
    ENSP00000228515.1, ENST00000228515.6
    Conserved Domains (1) summary
    pfam16019
    Location:62279
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

RNA

  1. NR_045072.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the 5' terminal exon compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ298133, BM975428, DB460042

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    51061205..51083596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449216.2XP_024304984.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
    Conserved Domains (1) summary
    pfam16019
    Location:62279
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
  2. XM_024449214.2XP_024304982.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
    Conserved Domains (1) summary
    pfam16019
    Location:62279
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
  3. XM_047429621.1XP_047285577.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
  4. XM_024449215.2XP_024304983.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
    Conserved Domains (1) summary
    pfam16019
    Location:62279
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
  5. XM_024449213.2XP_024304981.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
    Conserved Domains (1) summary
    pfam16019
    Location:62279
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
  6. XM_047429619.1XP_047285575.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
  7. XM_047429618.1XP_047285574.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
  8. XM_047429620.1XP_047285576.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
  9. XM_024449210.2XP_024304978.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
    Conserved Domains (1) summary
    pfam16019
    Location:62279
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
  10. XM_047429617.1XP_047285573.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
  11. XM_024449211.2XP_024304979.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
    Conserved Domains (1) summary
    pfam16019
    Location:62279
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
  12. XM_024449212.2XP_024304980.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9H175
    UniProtKB/TrEMBL
    B2R7Q9
    Conserved Domains (1) summary
    pfam16019
    Location:62279
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    51024095..51046514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373357.1XP_054229332.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7Q9
  2. XM_054373354.1XP_054229329.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7Q9
  3. XM_054373360.1XP_054229335.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7Q9
  4. XM_054373361.1XP_054229336.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7Q9
  5. XM_054373355.1XP_054229330.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7Q9
  6. XM_054373358.1XP_054229333.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7Q9
  7. XM_054373356.1XP_054229331.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7Q9
  8. XM_054373359.1XP_054229334.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7Q9
  9. XM_054373362.1XP_054229337.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7Q9
  10. XM_054373363.1XP_054229338.1  cysteine/serine-rich nuclear protein 2 isoform X1

    UniProtKB/TrEMBL
    B2R7Q9