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INTS14 integrator complex subunit 14 [ Homo sapiens (human) ]

Gene ID: 81556, updated on 14-Jul-2019

Summary

Official Symbol
INTS14provided by HGNC
Official Full Name
integrator complex subunit 14provided by HGNC
Primary source
HGNC:HGNC:25372
See related
Ensembl:ENSG00000138614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VWA9; C15orf44
Expression
Ubiquitous expression in thyroid (RPKM 12.8), testis (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See INTS14 in Genome Data Viewer
Location:
15q22.31
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (65578757..65611289, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65871095..65903627, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene dipeptidyl peptidase 8 Neighboring gene 3-hydroxyacyl-CoA dehydratase 3 Neighboring gene RNA, U6 small nuclear 19, pseudogene Neighboring gene uncharacterized LOC102723464 Neighboring gene solute carrier family 24 member 1 Neighboring gene DENN domain containing 4A Neighboring gene small nucleolar RNA, C/D box 13E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • RNA polymerase II transcribes snRNA genes, organism-specific biosystem (from REACTOME)
    RNA polymerase II transcribes snRNA genes, organism-specific biosystemSmall nuclear RNAs (snRNAs) play key roles in splicing and some of them, specifically the U1 and U2 snRNAs, are encoded by multicopy snRNA gene clusters containing tandem arrays of genes, about 30 in...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564O1664

Gene Ontology Provided by GOA

Process Evidence Code Pubs
snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
integrator complex subunit 14
Names
UPF0464 protein C15orf44
von Willebrand factor A domain containing 9
von Willebrand factor A domain-containing protein 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136043.3NP_001129515.1  integrator complex subunit 14 isoform 1

    See identical proteins and their annotated locations for NP_001129515.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in its 5' UTR, uses an alternate splice site in the central coding region, and uses a downstream start codon, compared to variant 4. The encoded isoform (1) is shorter, compared to isoform 4. Variants 1, 5, 9 and 10 encodes isoform 1.
    Source sequence(s)
    AA745705, AK301033
    Consensus CDS
    CCDS45283.1
    UniProtKB/Swiss-Prot
    Q96SY0
    Related
    ENSP00000402898.2, ENST00000431261.6
    Conserved Domains (1) summary
    cl17190
    Location:286410
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. NM_001207058.3NP_001193987.2  integrator complex subunit 14 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes isoform 4.
    Source sequence(s)
    AA745705, AK301033, AK301742
    Related
    ENSP00000456460.1, ENST00000569491.5
    Conserved Domains (1) summary
    cl17190
    Location:315439
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  3. NM_001207059.3NP_001193988.2  integrator complex subunit 14 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes isoform 1. Variants 1, 5, 9 and 10 encodes isoform 1.
    Source sequence(s)
    AA745705, AK293207, AK301033
    Consensus CDS
    CCDS55969.1
    Related
    ENSP00000408429.3, ENST00000420799.7
    Conserved Domains (1) summary
    cl17190
    Location:286410
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  4. NM_001366360.2NP_001353289.1  integrator complex subunit 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC027220
    Related
    ENSP00000326379.2, ENST00000313182.6
    Conserved Domains (2) summary
    pfam13519
    Location:3117
    VWA_2; von Willebrand factor type A domain
    cl17190
    Location:365489
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  5. NM_001366364.2NP_001353293.1  integrator complex subunit 14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC027220
    Conserved Domains (1) summary
    cl17190
    Location:286410
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  6. NM_001366365.2NP_001353294.1  integrator complex subunit 14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC027220
    Conserved Domains (1) summary
    cl17190
    Location:286410
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RNA

  1. NR_045104.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses alternate exon structure in the 5' region, compared to variant 4. This variant is represented as non-coding due to the presence of an upstream ORF that is expected to interfere with translation of the longest in-frame ORF. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC007991, DC298728
  2. NR_045105.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate exon structure in the 5' region, compared to variant 4. This variant is represented as non-coding due to the presence of an upstream ORF that is expected to interfere with translation of the longest in-frame ORF. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK296134, CA414283, DC376467
    Related
    ENST00000567744.5
  3. NR_045106.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate exon structure in the 5' region, compared to variant 4. This variant is represented as non-coding due to the presence of an upstream ORF that is expected to interfere with translation of the longest in-frame ORF. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK296134, AL136662, CA414283, DC313962
    Related
    ENST00000573314.5
  4. NR_045901.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses alternate exon structure in the 5' region, compared to variant 4. This variant is represented as non-coding due to the presence of an upstream ORF that is expected to interfere with translation of the longest in-frame ORF. Translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK296134, AK301222, CA414283

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    65578757..65611289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522101.2XP_011520403.1  integrator complex subunit 14 isoform X2

    See identical proteins and their annotated locations for XP_011520403.1

    UniProtKB/Swiss-Prot
    Q96SY0
    Conserved Domains (1) summary
    cl17190
    Location:286410
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. XM_006720711.2XP_006720774.1  integrator complex subunit 14 isoform X2

    See identical proteins and their annotated locations for XP_006720774.1

    UniProtKB/Swiss-Prot
    Q96SY0
    Conserved Domains (1) summary
    cl17190
    Location:286410
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030800.2: Suppressed sequence

    Description
    NM_030800.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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