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SGPP1 sphingosine-1-phosphate phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 81537, updated on 4-Jun-2020

Summary

Official Symbol
SGPP1provided by HGNC
Official Full Name
sphingosine-1-phosphate phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:17720
See related
Ensembl:ENSG00000126821 MIM:612826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPP-1; SPPase1
Summary
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]
Expression
Ubiquitous expression in kidney (RPKM 17.3), lymph node (RPKM 14.6) and 25 other tissues See more
Orthologs

Genomic context

See SGPP1 in Genome Data Viewer
Location:
14q23.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (63684216..63728108, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64150934..64194756, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene WD repeat domain 89 Neighboring gene RNA, U6 small nuclear 1162, pseudogene Neighboring gene uncharacterized LOC105370532 Neighboring gene RNA, U7 small nuclear 116 pseudogene Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Genetic determinants of circulating sphingolipid concentrations in European populations.
NHGRI GWA Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphingosine-1-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sphingosine-1-phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi ceramide transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of epidermis development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
sphinganine-1-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
sphingolipid biosynthetic process TAS
Traceable Author Statement
more info
 
sphingosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sphingosine-1-phosphate phosphatase 1
Names
hSPP1
hSPPase1
sphingosine-1-phosphatase 1
sphingosine-1-phosphate phosphohydrolase 1
spp1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030791.4NP_110418.1  sphingosine-1-phosphate phosphatase 1

    See identical proteins and their annotated locations for NP_110418.1

    Status: VALIDATED

    Source sequence(s)
    AJ293294, BC063839, HY008514
    Consensus CDS
    CCDS9760.1
    UniProtKB/Swiss-Prot
    Q9BX95
    Related
    ENSP00000247225.6, ENST00000247225.7
    Conserved Domains (2) summary
    COG0671
    Location:142284
    PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
    cd03388
    Location:126275
    PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    63684216..63728108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021678.2XP_016877167.1  sphingosine-1-phosphate phosphatase 1 isoform X1

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654721.1 Reference GRCh38.p13 PATCHES

    Range
    20168..64017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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